Medicinal Chemistry News and Research

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Kansas researchers secure NIH funding to fight antibiotic resistance

As antibiotic resistance makes everyday infections tougher to treat and emerging pathogens drive challenging infectious-disease outbreaks, researchers in Kansas from multiple disciplines and institutions are teaming up to target pathogens and overcome antibiotic resistance.

25 Sep 2026

New drug molecule reshapes protein to improve cancer target selectivity

A square peg doesn't fit a round hole. But what if the peg could change the shape of the hole?

16 Sep 2026

Generative AI-driven drug Rentosertib enters Phase III trial for idiopathic pulmonary fibrosis

Insilico Medicine, a clinical-stage biotechnology company powered by generative AI, today announced that it has dosed the first patient with Rentosertib (known as ISM001-055 / INS018_055) in GENESIS-IPF-3, a Phase III clinical trial (NCT07687459, CTR20262475) at Peking Union Medical College Hospital, while Shanghai Pulmonary Hospital has also enrolled its first patient on the same day.

10 Sep 2026

LSD deconstruction reveals promising new drug candidates

University of California, Davis researchers have stripped down LSD to the base features responsible for its hallucinogenic and therapeutic effects.

7 Sep 2026

Researchers develop mild skeletal editing method for medicinal chemistry

Researchers at Ritsumeikan University report a halogen-guided method for transforming accessible hydroxycoumarins into coumaranones, valuable heterocyclic structures in medicinal chemistry.

27 Aug 2026

Dual-action compounds show promise against aggressive cancer and infections

Cancer patients often face more than the disease itself. Their treatment is frequently complicated by infections and other health conditions, meaning they may need to take several different medications at once.

18 Aug 2026

'Locked' cancer therapeutic safely shrinks breast tumors in mice

Although there are many cancer treatments available today that effectively eliminate abnormal cells, these therapies may also damage healthy cells, leading to unwanted side effects.

13 Aug 2026

Researchers find unexpected protein regulator of leukemia drug sensitivity

How cells respond to the leukemia drug 6-thioguanine still holds surprises: A new study, led by researchers from CeMM and the University of Oxford identifies NUDT5 as an unexpected regulator of drug sensitivity and reveals that its role has nothing to do with its enzymatic activity.

12 Aug 2026

Study identifies a novel direct drug target for head and neck squamous cell carcinoma

Chemotherapy remains a cornerstone of treatment for head and neck cancers, the seventh-most common cancer type worldwide.

6 Aug 2026

Natural compounds could combat drug-resistant malaria and babesiosis

As parasites become increasingly resistant to existing drugs, researchers at the University of California, Riverside are working to develop a new generation of treatments for two serious infectious diseases: malaria and babesiosis.

31 Jul 2026

Insilico unveils standardized evaluation framework to validate AI-driven drug discovery models

As general-purpose and domain-specific AI models rapidly infiltrate drug discovery, one critical question looms over the pharmaceutical sector: Can these models actually discover drugs, or are they just good at taking tests?

30 Jul 2026

New approach enhances radiotherapy by disabling cancer's DNA repair machinery

Cancer treatments like radiation and chemotherapy work by doing one main thing: shredding the DNA of cancer cells so they can no longer multiply.

16 Jul 2026

How to overcome purification bottlenecks in modern drug discovery

Learn how to overcome purification bottlenecks in modern drug discovery with advanced purification strategies, streamlined workflows, and automation.

From TTP plc 15 Jul 2026

Combination treatment strategy uses cells' waste removal functions to dismantle multiple myeloma

New research out of VCU Massey Comprehensive Cancer Center provides promising evidence for an innovative combination treatment strategy that uses cells' waste removal functions to effectively dismantle multiple myeloma.

13 Jul 2026

VOYAGER electronic pipettes support breakthroughs in analgesia research

Purdue University researchers use VOYAGER pipettes to enhance drug discovery for non-opioid chronic pain therapies, improving assay throughput and accuracy.

From INTEGRA Biosciences 9 Jul 2026

New chemistry database helps speed up global drug discovery

Developing new medicines can require thousands of chemistry experiments to identify the right recipe for a safe, effective and ideally affordable drug.

22 Jun 2026

Deep learning identifies novel compounds against antibiotic-resistant gonorrhea

With tens of millions of annual cases, gonorrhea is the second most frequently reported sexually transmitted infection (STI). Alone in the U.S., over 600,000 cases are reported each year.

17 Jun 2026

Experimental vaccine protects against fentanyl and related opioids

Fentanyl and related variants of the synthetic opioid kill more Americans each year than car accidents and gun violence combined. In too-high doses, the drugs hijack brain chemistry and shut down the signals that control breathing.

11 Jun 2026

Automated self-driving labs accelerate the search for new medicines

The Acceleration Consortium (AC) at the University of Toronto and the Structural Genomics Consortium (SGC) announced today a formalized partnership to help tackle a persistent challenge in biomedicine and early drug discovery: the development of bioactive molecules with drug-like properties, advancing our understanding of human health and disease and jump-starting new drug discovery programs.

10 Jun 2026

ELRIG unveils keynote speakers for Drug Discovery 2026

ELRIG, a not-for-profit, volunteer-led organization dedicated to the global drug discovery community, today announced the keynote speaker program for Drug Discovery 2026.

From ELRIG (UK) Ltd. 3 Jun 2026