Medroxyprogesterone Acetate News and Research

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Self-administered injectable contraceptives face provider hesitancy despite availability

Self-administered injectable contraceptives have been available in the United States for more than two decades, yet a new study has found only about a quarter of reproductive health experts prescribe it - and many are unaware it's even an option.

9 Jan 2026

Low-dose megestrol strengthens hormone therapy in ER-positive breast cancer

Low-dose megestrol enhances hormone therapy for ER-positive breast cancer, reducing tumor proliferation and improving treatment adherence in the PIONEER trial.

7 Jan 2026

Some hormonal contraceptives linked to higher risk of breast cancer

Some common hormonal contraceptives are linked to a slightly higher risk of breast cancer than others.

30 Oct 2025

Hormone therapy boosts heart health markers but raises some risks

Researchers assess hormone therapy-induced changes in cardiovascular biomarkers.

29 Apr 2025

IVF and ICSI pregnancies show higher exposure to teratogenic medicines

A new Australian study has revealed a potential reason why some pregnancies achieved through assisted reproductive technology (ART) may result in birth defects in comparison to naturally conceived pregnancies.

15 Jan 2025

Estrogen-based hormone therapies have favorable long-term effects on heart disease risk

Recent studies show that women can experience bothersome menopause symptoms, like hot flashes, for longer than originally estimated.

10 Sep 2024

Researchers identify shared molecular mechanism in cancer and pregnancy that suppresses immune system

Researchers elucidated the shared immune tolerance mechanisms in cancer and pregnancy, focusing on the role of an immune checkpoint protein as an onco-fetal immune tolerance checkpoint.

11 Jul 2024

Certain progestogens linked to higher brain tumor risk in women, study suggests

Study finds long-term use of specific progestogens increases the risk of benign brain tumors in women, while short-term use and other progestogens do not.

3 Apr 2024

Contraceptive content shared on social media largely not from health experts, study finds

Brigham researchers looked at tweets from 2014 to 2019 about contraceptive methods and found that only a small fraction were authored by health professionals.

29 Mar 2024

Researchers identify increased brain tumor risk with specific contraceptive use

The intracranial meningioma risk associated with progestogen use.

28 Mar 2024

Long-term use of certain progestogen drugs may raise risk of intracranial meningioma

Prolonged use of certain progestogen hormone drugs is associated with an increased risk of developing a type of brain tumor known as an intracranial meningioma, finds a study from France published by The BMJ today.

27 Mar 2024

Contraception counseling, pregnancy planning are necessary to optimize health of women with heart disease

Pregnancy can increase the risk of morbidity and mortality in women with cardiovascular disease; however, many cardiologists are not having pre-pregnancy contraception discussions with their patients of child-bearing age.

5 Apr 2021

Contraceptive drug effective in preventing and regressing cervical cancer in mice

A new study in The American Journal of Pathology, published by Elsevier, reports that medroxyprogesterone acetate (MPA), the active ingredient in the common contraceptive injection Depo-Provera, was effective in preventing the development of cervical cancer in mice with precancerous lesions.

12 Nov 2019

Long-acting contraceptives do not increase risk of HIV, concludes new study

One of the largest and most robust studies on HIV infection rates has concluded that long-acting contraceptives do not increase the risk of contracting HIV.

14 Jun 2019

Study finds common contraceptive shot may increase HIV risk

A recent study found an association between HIV risk and the use of the common birth control medications DMPA, among women from sub-Saharan Africa.

9 Jan 2018

Popular contraceptive shot may raise risk of HIV infection

Transitioning away from a popular contraceptive shot known as DMPA could help protect women in Sub-Saharan Africa and other high-risk regions from becoming infected with HIV, according to a research review published in the Endocrine Society's journal Endocrine Reviews.

4 Jan 2018

Self-injection of contraceptive feasible, acceptable among women in sub-Saharan Africa, research reveals

Self-injection of the contraceptive Sayana® Press is both feasible and highly acceptable among women participating in the first such research study conducted in sub-Saharan Africa, according to results published online by the journal Contraception.

16 Nov 2016

Hormonal contraception may increase susceptibility of women to genital infection

Women account for approximately half of all individuals living with HIV worldwide, and researchers wanted to identify the risk factors that increase susceptibility of women to genital infection.

20 Apr 2016

Swedish population study helps answer lingering questions about hormone therapy safety

A Swedish population study is helping answer lingering questions about hormone therapy safety. Published online today in Menopause, the journal of The North American Menopause Society, the study shows that estrogen-only therapy carries a lower risk of blood clots than combined estrogen-progestogen therapy, but there is no significantly increased risk of clots with combination therapy when the estrogen is transdermal, and vaginal estrogen doesn't raise the risk at all.

30 Mar 2016

Progesterone supplements fail to improve birth rate among women with a history of miscarriage

A new study has shown that taking progesterone supplements during the first trimester of pregnancy does not improve the chances of maintaining pregnancy among women who have a history of unexplained recurrent miscarriage.

26 Nov 2015