Metastasis News and Research

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Metastasis is the spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a “metastatic tumor” or a “metastasis.” The metastatic tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases

New hybrid approach intensifies treatment for liver tumor metastases

Combining intraarterial and intravenous administration of peptide receptor radionuclide therapy (PRRT) can selectively intensify treatment for liver-dominant metastatic neuroendocrine tumors (NETs) while still effectively delivering treatment throughout the whole body.

13 Nov 2026

Scientists identify metabolic pathway driving lung cancer lymph node metastasis

Metabolic reprogramming plays a critical role in shaping the adaptive capabilities of malignant cells during dissemination.

12 Nov 2026

Childhood cancer cells shape-shift to spread without genetic mutations

Researchers at the University of East Anglia (UK) have proposed an explanation for why some childhood tumors spread aggressively around the body despite having relatively few genetic faults.

9 Nov 2026

New review outlines role of extracellular vesicles in cancer and aging

A new review was published in Volume 13 of Oncoscience on September 30, 2026, titled "Extracellular vesicles in health, aging and disease."

6 Nov 2026

Immune cell neighborhoods control cancer spread and metastasis formation

Published in Nature Cancer: Researchers at the Université libre de Bruxelles (ULB) have discovered that immune cells build distinct "neighborhoods" around cancer cells.

3 Nov 2026

New pediatric consensus standardizes surgical management of Wilms tumor

WT outcomes have improved substantially through progress in molecular diagnosis, chemotherapy, radiotherapy, and surgery. Yet surgical management remains inconsistent, especially for large tumors, adjacent-organ invasion, intravascular extension, nephron-sparing surgery (NSS), and lymph node biopsy.

2 Nov 2026

Immunotherapy reshapes immune cell interactions in melanoma-affected lymph nodes

A new study from Mayo Clinic suggests checkpoint immunotherapy may reshape the immune environment within lymph nodes after melanoma has spread to them.

30 Oct 2026

Targeting specific enzyme reverses radiation-induced immune suppression in cancer

Researchers at the University of Chicago identified a mechanism to make immune cells reprogrammed by radiation therapy attack tumors rather than protect them.

30 Oct 2026

Study establishes new perioperative standard in prostate cancer

An international phase 3 clinical trial that treated patients with high-risk localized and locally advanced prostate cancer with apalutamide - a next-generation neoadjuvant androgen-receptor pathway inhibitor (ARPI) - plus hormone therapy before and after prostate cancer surgery, was further validated by a substudy demonstrating a reduced risk of metastasis or death compared with standard of care.

27 Oct 2026

Personalized mRNA cancer vaccine cuts melanoma recurrence risk when added to immunotherapy

Adding a personalized mRNA-based cancer vaccine to immunotherapy after surgery for high-risk melanoma reduced the risk of recurrence or death by 42%, according to results from the phase 3 INTerpath-001 trial presented at the ESMO Congress 2026.

24 Oct 2026

Researchers identify molecular target to improve pancreatic cancer treatment

Pancreatic cancer is one of the most aggressive and difficult-to-treat cancers. One reason for its resistance to therapy is the dense tissue surrounding the tumor, which acts as a protective barrier and suppresses the immune response.

23 Oct 2026

Decipher tissue-based molecular test helps personalize high-risk prostate cancer treatment

Prostate cancer is the most common cancer in men – in 2013, it affected more than one million men across the world.

23 Oct 2026

Researchers use mitochondrial uncouplers to target breast cancer metastasis

Mitochondrial serine catabolic pathway (MSCP), also called serine, glycine, and one-carbon metabolism, is essential for cancer cells to produce amino acids, one-carbon units, and reducing equivalents.

19 Oct 2026

Pancreatic cancer cells continuously reshape DNA to evade treatment

A new analysis of nearly half a million cells from dozens of pancreatic tumors, led by researchers at UC San Diego Moores Cancer Center and New York University (NYU), reveals how pancreatic cancer cells continuously reshape their genetic makeup over time, enabling them to evade treatment.

13 Oct 2026

Single-cell analysis reveals how pancreatic cancer evades treatment

An analysis of nearly half a million cells from dozens of patients' tumors reveals how cancer cells continuously reshape their genetic makeup over time, enabling them to evade treatment for one of the deadliest forms of cancer.

13 Oct 2026

Long non-coding RNAs offer new pathways to overcome cancer treatment resistance

Scientists are highlighting long non-coding RNAs (lncRNAs) as promising targets in the effort to overcome one of cancer treatment's most persistent challenges: therapeutic resistance.

12 Oct 2026

RNA modification enzyme FTO shows therapeutic promise in gastrointestinal cancers

A new review in Genes & Diseases highlights FTO, an enzyme involved in RNA modification, as a potentially important biomarker and therapeutic target across gastrointestinal cancers.

12 Oct 2026

SPRED2 coordinates three signaling pathways to suppress liver cancer stemness

Liver cancer is the fifth most commonly diagnosed cancer and the second leading cause of cancer death worldwide. Hepatocellular carcinoma (HCC) accounts for 70-85% of primary liver cancers, and its five-year recurrence rate can reach 70-80%.

8 Oct 2026

Rare dendritic cells may promote immune tolerance in metastatic cancer

This study was co-led by Steven Blum, MD. Gary Reynolds, MD, PhD, Samuel Klempner, MD, and Alexandra-Chloé Villani, PhD, jointly supervised the work at the Krantz Family Center for Cancer Research within the Mass General Brigham Cancer Institute and the Mass General Brigham Center for Immunology & Inflammatory Diseases (CIID).

8 Oct 2026

Disrupted circadian rhythms may influence tumor immunity and cancer spread

Epidemiological studies link light at night (LAN), shift work, chronic jet lag (CJL), and core clock gene mutations to higher cancer risk and aggressive spread, especially in breast and colorectal cancer.

8 Oct 2026