Microdosing News and Research

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Psilocybin microdosing sounds promising, but the strongest studies tell a different story

A systematic review of 11 studies involving 3,262 adults found that psilocybin mushroom and truffle microdosing was associated with reported improvements across areas including mental health, well-being, cognition, creativity, and social functioning. However, the evidence was methodologically weak and highly heterogeneous, the two placebo-controlled trials found no significant improvements, and inadequate adverse-event reporting means efficacy and safety remain uncertain.

7 Sep 2026

GLP-1 drugs have benefits beyond weight loss. Could microdoses preserve them?

A narrative review suggests GLP-1-based therapies deliver metabolic, cardiovascular, renal, and other systemic benefits, raising interest in whether lower fractional doses could improve tolerability and treatment continuity. However, direct evidence for GLP-1 microdosing remains extremely limited, and researchers say prospective studies are needed to determine whether lower doses preserve long-term benefits.

1 Sep 2026

Scientists urge caution over psychedelics as ADHD treatment

In recent years, there has been growing interest among adults with ADHD in the practice of microdosing classic psychedelics such as psilocybin and LSD.

1 Jul 2026

Cannabis leads microdosing trends among U.S. adults, study finds

Researchers from University of California San Diego have found that microdosing - taking very small amounts of psychoactive substances - is more common among U.S. adults than previously recognized, with cannabis leading by a wide margin.

4 May 2026

Psychedelic microdosing can temporarily boost mood

A new UBC Okanagan study found that people who microdose psychedelics feel better on the days they take them-but those boosts don't seem to last.

11 Dec 2025

Indero announces breakthrough method for early-phase evaluation of topical drugs using quantitative gene expression

Indero is proud to announce the successful completion of an internally funded study that introduces a novel approach to evaluating topical new chemical entities (NCE) in early-phase clinical research.

14 Nov 2025

Systematic analysis reveals psilocybin's impact on obsessive-compulsive behaviors

A systematic review published today in Psychedelics by Mr. James Gattuso and colleagues at the Florey Institute of Neuroscience and Mental Health synthesizes clinical and preclinical evidence on psilocybin's effects on obsessive-compulsive behaviors, revealing consistent therapeutic potential across human patients and validated animal models.

29 Oct 2025

Can psychedelics break compulsive eating habits in obesity?

A review by Oxford researchers explores how psychedelics like psilocybin and LSD may help disrupt compulsive eating behaviors in subsets of obese individuals. The paper outlines proposed neurobiological, epigenetic, and gut-brain mechanisms while emphasizing the need for human trials.

10 Apr 2025

Low-dose initiation of buprenorphine for people using fentanyl fails to deliver expected results

During the COVID-19 pandemic, when fentanyl overdoses surged, doctors were desperate to find ways of helping their patients.

24 Jan 2025

Google searches reveal growing interest in microdosing amid changing drug policies

Loosening local, state and federal regulations on cannabis and psychedelics has increased Americans' interest in microdosing, according to a study from researchers at the University of California San Diego.

28 Jun 2024

Psilocybin mushrooms in America: Usage trends and policy implications

Psilocybin mushrooms are the psychedelic substance most often used in the U.S., with its popularity outpacing other psychedelic drugs such as MDMA (known as ecstasy), according to a new RAND report.

27 Jun 2024

The unregulated sale of Amanita muscaria mushrooms needs a public health response

The legal status, safety, and availability of Amanita muscaria.

12 Jun 2024

Study finds microdosing LSD leads to longer sleep: Insights from a controlled trial

A phase I trial to assess the effect of micro-dosing of lysergic acid diethylamide (LSD) on the sleep.

17 Apr 2024

The therapeutic effects and safety of psychedelics

Psychedelics are reported to have rapid-onset and long-lasting therapeutic benefits after a single or few doses.

14 Dec 2022

Psilocybin microdosing associated with mood and mental health improvements

The latest study to examine how tiny amounts of psychedelics can impact mental health provides further evidence of the therapeutic potential of microdosing.

11 Jul 2022

Placebo-like effects may explain the benefits of psychedelic drugs

Positive psychological effects associated with taking small doses of psychedelic drugs are likely the result of users' expectations, suggests a study published today in eLife.

3 Mar 2021

New microneedle patches for delivery of psychedelic pharmaceuticals

Although one may think of psychedelic pharmaceuticals as being dangerous and detrimental, scientists have been conducting experiments and clinical trials on some of them and have obtained positive results when testing them for medical use.

23 Feb 2021

Antibiotic combined with measurement technology may save time and money in developing new active ingredients

A minimal – and therefore innocuous – dose of an antibiotic coupled with highly sensitive measurement technology could save time and money in the development of new active ingredients.

7 May 2020

New ‘microdose’ psychedelic treatment appears to relieve anxiety and depression

Lava lamps, tambourines and, of course, psychedelic drugs were hallmarks of the 1960s. Psychedelic drugs can make people euphoric, though users can also become extremely anxious and agitated. But that's at a high dose.

5 Mar 2019

Study looks at effects of microdosing of psychedelics on mental health

Microdosing of psychedelic substances involves taking very small doses of a psychedelic drug such as LSD or psilocybin (magic mushrooms) over weeks or even months. There have been anecdotal claims that such microdosing can improve health and also performance and relationships. These earlier studies dealt with the one time effect of microdosing.

6 Feb 2019