Myeloperoxidase News and Research

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Myeloperoxidase (MPO) is a peroxidase enzyme most abundantly present in neutrophil granulocytes (a subtype of white blood cells). It is a lysosomal protein stored in azurophilic granules of the neutrophil. MPO has a heme pigment, which causes its green color in secretions rich in neutrophils, such as pus and some forms of mucus.

Could scorpion venom inspire new treatments for liver disease?

Scorpion venom peptides show promising anti-inflammatory, antiviral, analgesic, and immunomodulatory effects, with experimental evidence suggesting that some candidates could target pathways involved in chronic liver disease and viral hepatitis. The review highlights Kv1.3-blocking peptides and antiviral compounds as potential therapeutic leads, while emphasizing that limited hepatic efficacy data, poor pharmacokinetics, immunogenicity, and manufacturing challenges must be overcome before clinical translation.

8 Sep 2026

Too little or too much iodine may push immunity off balance

This narrative review finds that adequate iodine supports thyroid hormone signaling, leukocyte metabolism, antioxidant defenses, and antimicrobial activity in humans and domesticated mammals. Both deficiency and sustained excess may impair immunity or promote thyroid inflammation, but precise immune-specific intake thresholds remain uncertain.

27 Jul 2026

Animal-free lung model unlocks better treatments for RSV in babies

Future therapies for respiratory syncytial virus (RSV) must target both the virus and its immune response to ensure babies get the best possible outcomes, finds a new study by researchers at UCL and Great Ormond Street Hospital for Children (GOSH).

13 Jul 2026

Targeting specific immune pathways could prevent severe reperfusion injury

IRI is a shared pathological process in myocardial infarction, ischaemic stroke, acute kidney injury, lung injury, and graft dysfunction after transplantation.

26 Jun 2026

New compounds reduce inflammation without weakening immune defense

Scripps Research scientists have developed a new class of drug compounds that reduce harmful inflammation while leaving the body's ability to fight infections intact-a long-sought goal in treating autoimmune diseases.

6 Apr 2026

Prebiotic microcapsules deliver pterostilbene to the colon to alleviate ulcerative colitis

A team led by clinicians and engineers has wrapped the plant-derived polyphenol pterostilbene (PSB) into prebiotic alginate/resistant-starch microcapsules coated with chitosan and shown that oral administration dampens dextran-sulfate-sodium (DSS) colitis in mice.

23 Dec 2025

How fiber intake shapes your gut microbes’ digestion strategy

A study reveals how gut bacteria shift from fiber to mucus digestion, linking this change to inflammation in healthy adults and introducing the Muc2Plant ratio.

5 Sep 2025

Heavy smoking triggers systemic inflammation and vascular damage in new biomarker study

Heavy smoking in adult males significantly increases oxidative stress, inflammation, and vascular dysfunction, as shown by comprehensive blood and tissue biomarker analysis. The findings highlight measurable biological damage and reinforce the urgent need for targeted public health interventions.

26 May 2025

Digital lifestyle program cuts diabetes risk by 46% in prediabetics, study of 130k+ adults reveals

A large study of 133,764 adults found that a voluntary digital lifestyle program reduced 10-year diabetes risk by 45.6% in prediabetics and doubled remission rates in diabetics, with significant improvements in triglycerides, insulin resistance, and inflammatory markers like hs-CRP.

14 Apr 2025

Rising IBD incidence highlights need for non-invasive biomarkers in diagnosis

The global burden of inflammatory bowel diseases (IBD), primarily Crohn's disease (CD) and ulcerative colitis (UC), continues to rise. Recent data show incidence rates of up to 17.8 cases per 100,000 person-years for CD and even higher for UC, reaching 28.4 per 100,000 person-years. These diseases primarily affect older populations and vary geographically, with higher prevalence rates in highly developed countries.

23 Aug 2024

Tea, coffee, and fruits found to be top contributors to polyphenol intake in study exploring GI inflammation in healthy adults

Researchers estimated dietary polyphenol intake in healthy adults and investigated its associations with gastrointestinal and systemic inflammation markers.

21 Aug 2024

How the MIND diet may protect against dementia

Researchers utilize transcriptomic data to examine the protective effects of the MIND diet in reducing the risk of dementia and slowing cognitive decline.

20 Aug 2024

The role of banana lectin in mitigating inflammatory bowel disease

The therapeutic role of recombinant banana lectin (rBanLec) concerning IBD control and raising vaccination rates.

3 Jun 2024

Limoncella apple polyphenol extract shines in IBD liver damage study

'Limoncella' apple polyphenol extract (LAPE) shows promise in reducing liver and intestinal inflammation in a mouse model of inflammatory bowel disease (IBD), highlighting potential natural treatment pathways

12 Mar 2024

Moderate wine consumption may reduce the risk of some cancers

A meta-analysis published in Frontiers in Nutrition finds no link between moderate wine consumption and increased cancer risk; instead, it suggests that wine may have protective effects against certain types of tumors. Further research is needed to confirm these findings and understand the mechanisms involved.

26 Oct 2023

Is a vegan diet a healthy choice for kids?

In a comprehensive review published in Critical Reviews in Food Science and Nutrition, scientists analyzed the health implications of vegan diets in children and adolescents. The study reveals both benefits and concerns, highlighting lower cholesterol levels but potential nutritional deficiencies that might affect bone health.

10 Oct 2023

Ginger shows promise as a natural defense against autoimmune diseases

Comprehensive study reveals that whole ginger extracts have a significant impact on inhibiting neutrophil hyperactivity, a key factor in autoimmune diseases like APS and lupus. Consuming ginger for just a week showed promising results in both animal models and human trials, positioning it as a natural and affordable treatment option for a range of autoimmune disorders.

2 Oct 2023

Color of the phlegm can indicate degree of lung inflammation in patients with bronchiectasis

The color of the phlegm from patients with the lung disease bronchiectasis can indicate the degree of inflammation in their lungs and predict their future outcomes, according to new research presented at the European Respiratory Society International Congress in Milan, Italy.

11 Sep 2023

Small molecule inhibitor of the NLRP3 inflammasome for treating autoinflammatory diseases

Researchers described the preclinical profile of JT002, a novel and orally bioavailable small molecule inhibitor of the NLRP3 inflammasome.

24 Aug 2023

Is there an association between dairy intake and markers of gastrointestinal inflammation?

Researchers determined the links between dairy consumption and gastrointestinal (GI) inflammatory markers.

10 Aug 2023