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What your gut microbes may have to do with how your brain ages

This review examines how diet-driven changes in the gut microbiota and microbial metabolites may influence cognitive aging through immune, metabolic, neural, endocrine, and barrier-related pathways. It highlights SCFAs, tryptophan-derived metabolites, and bile acids as key signaling mediators while emphasizing that much of the mechanistic evidence remains preclinical and human evidence is largely associative.

3 Sep 2026

The four-day week has plenty of fans. Now researchers are testing what it really changes

The Sussex 4-Day Week study is a 14-week UK protocol designed to investigate how reduced working hours affect physical and mental health, wellbeing, sleep, work performance, and potential biological and psychological mechanisms. Researchers aim to combine questionnaires with actigraphy, inflammatory biomarkers, interoception testing, and brain imaging in at least 150 adults, with data collection expected to continue until 2027.

3 Sep 2026

New research visualizes how aerobic exercise alters brain activity patterns

Researchers at AIST, in collaboration with the University of Texas Southwestern Medical Center in the United States, examined changes in brain activity during cognitive tasks before and after acute aerobic exercise in young and older healthy adults.

2 Sep 2026

Precision psychiatry aims to match schizophrenia patients with tailored medicines

Imagine watching a son or daughter begin college during a formative time in life, only to have schizophrenia suddenly alter their reality.

31 Aug 2026

Multi-ancestry genetic score improves risk prediction for Alzheimer's disease

Late-onset Alzheimer disease (AD) is a progressive disorder characterized by cognitive decline and memory impairment, affecting an estimated 6.9 million people in the U.S.

27 Aug 2026

Study finds distinct patterns of innate immune activity in mental disorders

The immune system may also play a role in mental disorders. Scientists are investigating these links with brain function in greater detail, and new findings show that immune changes may differ by disorder type.

25 Aug 2026

Researchers explore the link between tau levels and depressive symptoms in older people

During typical aging and Alzheimer's disease progression, higher levels of a protein called tau are associated with more depressive symptoms.

24 Aug 2026

A childhood shaped by sugar rationing was linked to mental health more than 50 years later

UK Biobank researchers examined whether sugar rationing during pregnancy and the first two years of life was associated with adult sweet-food preferences, sugar intake, brain structure, anxiety, and depression.

23 Aug 2026

Two distinct types of brain tissue work together to support cognition in older adults

Researchers from the Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) at the Keck School of Medicine of USC have found that two distinct types of brain tissue work together to support cognition in older adults, and that the health of the brain's short-range wiring may help soften the cognitive effects of gray matter loss.

20 Aug 2026

Shifting expectations of unpredictability could help treat schizophrenia delusions

New research has found that improvements to the severity of delusions in patients with schizophrenia-spectrum disorder recovering from an acute psychotic episode were significantly associated with reductions in volatility priors—someone's expectations about the unpredictability of their environment.

18 Aug 2026

Five-week training program helps college students regulate their emotions

A five-week training intervention taught college students to better regulate their emotions in response to negative events, a new study finds.

18 Aug 2026

Brain activity before stimulation predicts treatment responses

Brain stimulation can produce very different effects at different moments, even when the stimulus is delivered the exact same way.

14 Aug 2026

Two early-life findings stood out in children who later screened positive for autism risk

Children born very preterm were more likely than term-born children to screen positive for autism risk at age 5 using the Social Communication Questionnaire. Among very preterm children, cerebellar abnormalities at term-equivalent age and moderate-to-severe histologic chorioamnionitis were independently associated with higher autism screening risk, alongside male sex and higher social risk.

13 Aug 2026

Automated MRI system improves improves evaluation of experimental stroke therapies

Researchers from the Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) at the Keck School of Medicine of USC have developed an automated system that uses MRI to measure brain tissue changes in animal models for large, multicenter studies of experimental stroke treatments.

12 Aug 2026

New USC center seeks answers to sex differences in aging

Women live longer than men in nearly every country in the world, yet they experience higher rates of disability, dementia and many other age-related conditions.

7 Aug 2026

Light-field microscopy enables snapshot volumetric imaging of fast neural activit

Neural activity is three-dimensional and fast. Signals propagate through brain circuits on millisecond-to-microsecond timescales, while animals move, sense, and act.

6 Aug 2026

High-resolution scans reveal how depression affects hippocampal subfields

Researchers from the USC Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) at the Keck School of Medicine of USC have found that depression is associated with smaller volume in a specific part of the hippocampus, a brain region essential for learning and memory.