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Researchers develop mild skeletal editing method for medicinal chemistry

Researchers at Ritsumeikan University report a halogen-guided method for transforming accessible hydroxycoumarins into coumaranones, valuable heterocyclic structures in medicinal chemistry.

27 Aug 2026

New chemistry database helps speed up global drug discovery

Developing new medicines can require thousands of chemistry experiments to identify the right recipe for a safe, effective and ideally affordable drug.

22 Jun 2026

New chemical reaction enables precise functionalization of peptides and proteins

Pharmaceutical scientists at the National University of Singapore (NUS) have developed a novel chemical reaction that enables the precise functionalization of peptides and proteins.

28 Feb 2025

Breakthrough in chemical synthesis expands possibilities for ketones and esters

Scientists have long considered ketones (a fundamental chemical class) and esters (molecules formed when an acid reacts with an alcohol) to be locked treasure chests of possibilities.

10 Jan 2025

Ingenza partners with HydRegen to advance sustainable biomanufacturing

Ingenza's collaboration with HydRegen focuses on optimizing enzyme expression, paving the way for greener, cost-effective manufacturing of amine chemicals.

From Ingenza Ltd 9 Jan 2025

New modular strategy reduces piperidine synthesis steps for pharmaceuticals

A team of chemists from Scripps Research and Rice University has unveiled a novel method to simplify the synthesis of piperidines, a key structural component in many pharmaceuticals. The study, published in Science, combines biocatalytic carbon-hydrogen oxidation and radical cross-coupling, offering a streamlined and cost-effective approach to create complex, three-dimensional molecules. This innovation could help accelerate drug discovery and enhance the efficiency of medicinal chemistry.

20 Dec 2024

Photocatalysed flow method accelerates synthesis of potent MC4R antagonist

Asynt report that the Cresswell Group, led by Dr Alexander J. Cresswell at the University of Bath (UK), have demonstrated the synthesis of novel spirocyclic tetrahydonaphthyridines (THNs) expanding the chemical space of these important scaffolds for drug discovery.

From Asynt 17 Dec 2024

Proline-based nano cages offer targeted drug delivery, limit side effects of chemotherapy

A new method of drug delivery using proline, an amino acid found in chicken feathers and skin tissue, could be used to limit the side effects of chemotherapy and repair important enzymes, new research suggests.

29 May 2024

AI-powered "Coscientist" system designs and executes chemical reactions

In less time than it will take you to read this article, an artificial intelligence-driven system was able to autonomously learn about certain Nobel Prize-winning chemical reactions and design a successful laboratory procedure to make them.

20 Dec 2023

Study finds α5 integrin as a potential therapeutic target in amyotrophic lateral sclerosis

Researchers examined the therapeutic effects of targeting integrins for treating Amyotrophic lateral sclerosis (ALS).

3 Aug 2023

Researchers convert β-Pinene into renewable feedstock for sustainable paracetamol and ibuprofen

Researchers have developed scalable processes to convert β-pinene into 4-IPEC, a feedstock for synthesizing sustainable versions of paracetamol and ibuprofen.

19 Jul 2023

Researchers develop novel molecular nanocages for siRNA delivery

Small interfering RNAs (siRNAs) are novel therapeutics that can be used to treat a wide range of diseases.

19 Apr 2023

Chemical compounds containing special metals can fight fungal infections

An international collaboration led by researchers from the University of Bern and the University of Queensland in Australia has demonstrated that chemical compounds containing special metals are highly effective in fighting dangerous fungal infections.

23 Sep 2022