Small Molecules News and Research

RSS

Novel method identifies active tRNAs during cellular protein synthesis

In a new study in Nature Methods, researchers at the Centre for Genomic Regulation (CRG) in Barcelona describe a technique that looks only at the tRNAs on ribosomes busy making proteins.

5 Nov 2026

Study identifies new target to improve ulcerative colitis treatments

Ulcerative colitis (UC) is a chronic, relapsing inflammatory bowel disease in which persistent mucosal inflammation damages the epithelial barrier.

3 Nov 2026

New study identifies biological mechanism driving therapy resistance in advanced prostate cancer

A multi-institutional collaborative study led by researchers at the University of Chicago and the Fred Hutchinson Cancer Center has identified a previously unknown biological mechanism that controls cell identity and treatment resistance in advanced prostate cancer.

3 Nov 2026

Plant-derived compound helps restore cancer cells' sensitivity to treatment

A natural plant compound may help overcome a built-in defense that allows many cancers to resist a class of drugs designed to restore normal gene activity, according to a study by researchers at the Johns Hopkins Sidney Kimmel Comprehensive Cancer Center.

2 Nov 2026

Researchers uncover molecular pathway controlling bone resorption and tooth eruption

RUNX2 is best known as a master transcription factor of osteoblast differentiation. Mutations in, or haploinsufficiency of RUNX2 cause CCD, a skeletal disorder characterized by delayed permanent tooth eruption, supernumerary teeth and clavicular defects.

30 Oct 2026

New Yale initiative explores the role of inflammation in disease

Yale School of Medicine (YSM) was awarded a $10 million grant from the Blavatnik Family Foundation (BFF) to launch a new research initiative in the field of inflammation science.

29 Oct 2026

DEBRA research invests in Topadur to advance small-molecule therapies for dystrophic Epidermolysis bullosa

DEBRA Research gGmbH, a global non-profit organization dedicated to advancing research and drug development for Epidermolysis bullosa (EB), and Topadur Pharma AG, a Swiss clinical-stage biopharmaceutical company, today announced an investment by DEBRA Research in Topadur to support a preclinical program exploring a new treatment approach for dystrophic Epidermolysis bullosa (DEB). DEB is one of the more severe forms of EB, characterized by extremely fragile skin and progressive, debilitating complications.

28 Oct 2026

New study identifies protein factor linked to chronic liver disease

The mechanisms that cause the world's most common chronic liver disease — Metabolic dysfunction-associated steatotic liver disease (MASLD) — to develop and progress are not still fully understood.

20 Oct 2026

Researchers capture clear images of complex cancer drug building enzyme

A joint research group led by Ryo Tanifuji and Hiroki Oguri from the University of Tokyo and Yoshikazu Tanaka from Tohoku University has successfully visualized SacC, an enzyme that plays a key role in building the complex five-ring core of safracin B.

19 Oct 2026

Switching to a vegan diet rapidly alters liver metabolism

A team from UNIGE has shown that switching from a vegetarian to a vegan diet is enough to modify the liver’s metabolism within a few days.

13 Oct 2026

Bio-Techne expands global GMP manufacturing network with new Bristol facility to advance scalable cell therapy development

Bio-Techne Corporation, a global provider of life science tools, reagents and diagnostic products, today announced the opening of a new manufacturing facility for Good Manufacturing Practice (GMP) grade small molecules in Bristol, United Kingdom, further expanding the company's global capabilities to support the rapidly growing cell therapy market.

From Bio-Techne 8 Oct 2026

UCLA scientist develops new way to map cellular metabolism

Nutrition advice is everywhere. Eat more protein. Cut back on sugar. Get more fiber. But beneath all that advice is a surprisingly basic gap in our understanding: Scientists still have a limited view of what happens when specific nutrients reach individual cells inside the body.

6 Oct 2026

New fluorescent paper strips make vitamin B12 testing simpler

Measuring vitamin B12 in food usually means bringing the sample to the laboratory. A new fluorescent sensor could help move part of that process onto something much simpler: a paper strip or cotton swab.

1 Oct 2026

New nanoparticles could protect soldiers from deadly nerve agents

Nanoparticles could someday provide a new way to help soldiers fight back against deadly nerve agents on the frontline.

29 Sep 2026

Structural insights into synchronous calcium channel gating in muscle cells

Using cryo-electron microscopy, researchers at the Max Delbrück Center have revealed how muscle cell calcium channels open synchronously.

24 Sep 2026

Forge Nano and Nanexa enter joint development agreement to advance manufacturing for ALD-coated PharmaShell® long-acting injectable medicines

Forge Nano, Inc., a leading U.S.-based semiconductor equipment and advanced materials company pioneering Atomic Layer Deposition ("ALD") technology for artificial intelligence ("AI")-era chip manufacturing and defense battery applications, which has signed an agreement to merge with Archimedes Tech SPAC Partners II Co. ("Archimedes II"), today announced a Joint Development Agreement ("JDA") with Nanexa AB to develop scalable pharmaceutical manufacturing capabilities for Nanexa's PharmaShell® drug delivery platform and its portfolio of proprietary and partnered programs.

From Forge Nano 23 Sep 2026

Discovery of receptor-free signaling reveals better targets for treating autoimmune diseases

Our understanding of how cells interact with each other has been driven for decades by the central concept of receptor-mediated signal transduction.

23 Sep 2026

C-Path awards $1.7 million to advance five drug development projects

Critical Path Institute (C-Path) today announced that its Translational Therapeutics Accelerator has awarded $1,699,500 through five Bridging Research and Innovation in Drug Development Grants (BRIDGe).

22 Sep 2026

Scientists reveals how cancer-causing p53 mutations remain invisible to the immune system

One of the biggest challenges in cancer immunotherapy may not be that immune cells are too weak, but that some tumors give them too little to see.

17 Sep 2026

Cannabis-derived nanovesicles showed early antitumor potential in mice

Researchers developed a Cannabis sativa hairy root culture system that produced stable plant-derived nanovesicles capable of promoting dendritic cell maturation and activating T-cell responses through TLR2- and TLR4-associated signaling. Oral administration also restored selected immune responses in immunosuppressed mice and suppressed tumor growth in an E.G7 lymphoma model, providing preliminary evidence for their immunomodulatory and antitumor potential.

15 Sep 2026