Tramadol News and Research

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Vitamin D deficiency linked to higher postoperative breast cancer pain

Vitamin D deficiency is associated with more moderate to severe pain following breast cancer surgery and an increased consumption of opioid drugs, finds research published online in the journal Regional Anesthesia & Pain Medicine.

19 May 2026

Opioids offer limited short-term relief for acute pain

The world's largest review of opioid pain relievers prescribed for acute pain found these medicines provide only small, short-term relief for some acute conditions and are ineffective for some others.

25 Feb 2026

Maxillary nerve block may reduce perioperative opioid consumption in pediatric primary clefts

For infants undergoing cleft palate surgery, local anesthetic injection targeting the maxillary nerve of the face may reduce or eliminate the need for opioid medications to control postoperative pain, reports a study in The Journal of Craniofacial Surgery.

12 Dec 2025

Common painkiller and antidepressant combo may increase seizure risk in older adults

When older adults living in nursing homes are prescribed the pain medicine tramadol alongside certain antidepressants, their risk of seizures may go up, according to a study published October 8, 2025, in Neurology, the medical journal of the American Academy of Neurology.

8 Oct 2025

Tramadol found to offer limited relief for chronic pain while raising risk of serious side effects

The strong opioid painkiller, tramadol, is not that effective at easing chronic pain for which it's widely prescribed, finds a pooled data analysis of the available research, published online in BMJ Evidence Based Medicine.

7 Oct 2025

How do common painkillers drive stronger E. coli resistance?

Research shows that non-antibiotic medications like ibuprofen can enhance E. coli mutations, raising concerns about antimicrobial resistance in older adults.

29 Aug 2025

Common painkillers ibuprofen and paracetamol found to fuel antibiotic resistance

Ibuprofen and paracetamol are common over-the-counter medications that many of us reach for when we're sick. But new research from the University of South Australia shows that these trusted staples are quietly fuelling one of the world's biggest health threats: antibiotic resistance.

25 Aug 2025

Safe storage crucial to prevent child drug poisoning

New data shows that the number of children suffering a seizure after swallowing medications or illegal substances has doubled between 2009 and 2023 in the US. The findings were presented today (Wednesday) at the European Emergency Medicine Congress.

16 Oct 2024

Tiny molecule offers hope in reducing opioid side effects

Opioid drugs are highly effective at relieving pain but come with severe drawbacks. Their side effects range from dizziness to potentially fatal respiratory depression.

9 Oct 2024

AAP publishes first clinical guideline for opioid use in pediatric care

The American Academy of Pediatrics has published its first clinical guideline for pediatricians on prescribing opioids, including explicit instructions on how and when to prescribe these medications for pain while reducing the long-term risk of addiction.

30 Sep 2024

Chiropractic care reduces tramadol prescriptions for sciatica, study finds

A new study led by researchers at University Hospitals Connor Whole Health found that adults initially receiving chiropractic spinal manipulation for newly diagnosed radicular low back pain (sciatica) were significantly less likely to be prescribed tramadol over the following year compared to those receiving usual medical care.

16 May 2024

What is the association between prenatal opioid exposure and risk of immune-related conditions?

Researchers compared the risk of hospitalization and emergency department presentation for immune-related conditions in children with and without prenatal opioid exposure.

19 Jan 2024

High-dose CBD fails to relieve pain in knee osteoarthritis patients

Cannabidiol (CBD) is marketed by some suppliers as a painkiller, e.g. for osteoarthritis of the knee. Animal experiments have shown that the substance, which is extracted from the hemp plant, has an anti-inflammatory and pain-relieving effect in arthritis.

14 Nov 2023

One health wake-up call: London's river data highlights environmental perils

The largest-ever spatiotemporal monitoring of chemicals/contaminants of emerging concern (CECs) in London waterways.

26 Sep 2023

New guideline supports use of acetaminophen and NSAIDs for pediatric dental pain

Acetaminophen or non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen are recommended as first-line treatments for managing short-term dental pain in children under age 12, according to a new clinical practice guideline developed by the American Dental Association Science & Research Institute (ADASRI), the University of Pittsburgh School of Dental Medicine and the Center for Integrative Global Oral Health at the University of Pennsylvania School of Dental Medicine.

25 Aug 2023

Understanding factors associated with long-term opioid use in fibromyalgia patients

Fibromyalgia is common, affecting around 2% of people in the general population. The 2017 EULAR recommendations state that tramadol - a weak opioid - may be considered for pain management in fibromyalgia, but advise against use of strong opioids due to lack of evidence of efficacy, and the high risk of side effects and addiction.

2 Jun 2023

Study finds lack of high certainty evidence on the efficacy and safety of analgesics for low back pain

Despite nearly 60 years of research, there is still a lack of high certainty evidence on the effectiveness and safety of commonly used painkillers (analgesics) for short bouts of low back pain, finds an analysis of the evidence published by The BMJ.

23 Mar 2023

New approach to pain management can reduce opioid use after urethroplasty

For men undergoing surgery to repair scarring in the urethra (urethroplasty), a new approach to pain management can reduce the need for strong opioid drugs without compromising pain control, reports a study in Urology Practice, an Official Journal of the American Urological Association.

21 Feb 2023

NY docs are now required to prescribe naloxone to some patients on opioid painkillers

Without opioid painkillers to dull the ache in his knees and other joints, Arnold Wilson wouldn't be able to walk half a block. The 63-year-old former New York City nurse has crippling arthritis for which he takes OxyContin twice a day and oxycodone when he needs additional relief.

5 Jan 2023

New long-term opioid use associated with a heightened risk of death, study finds

New long term use of opioids to quell pain after lung cancer surgery is linked to a 40% heightened risk of death from any cause within the next 2 years, finds research published online in the journal Regional Anesthesia & Pain Medicine.

13 Sep 2022