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In vivo CAR-T therapy transforms customized treatments into universal medicines

A collaborative team led by Professor Huji Xu from Naval Medical University, China, together with Professors Xuanming Yang and Yujia Cai at Shanghai Jiao Tong University, China, published a comprehensive review in Volume 2, article number 33 of the journal Immunity & Inflammation on August 31, 2026.

25 Sep 2026

Study explains how stroke promotes aggressive glioma tumor growth

Researchers at Texas Children's Duncan Neurological Research Institute (Duncan NRI), Baylor College of Medicine and collaborating institutions show in Nature Cancer that stroke promotes glioma growth and uncovered cellular and molecular mediators involved in the process, linking brain injury to malignant brain tumors.

25 Sep 2026

Neuromedin U drives immune suppression in aggressive prostate cancer

A new study from The Wistar Institute has found a link between the nervous system and the rapid development of neuroendocrine prostate cancer (NEPC), an aggressive form of the disease.

24 Sep 2026

USP15 enzyme emerges as potential target for ovarian cancer treatment

Ovarian cancer is often diagnosed after it has already spread to other parts of the body, at which point the five-year survival rate is under 30 percent.

24 Sep 2026

AI model predicts immunotherapy-related pneumonitis risk from CT scans

Researchers at The University of Texas MD Anderson Cancer Center have developed an artificial intelligence (AI) model that can identify lung cancer patients at increased risk of developing a serious immunotherapy-related side effect before treatment begins, offering a possible path toward more personalized monitoring and prevention strategies.

24 Sep 2026

MIT biologists discover cellular pathway that triggers colon cancer spread

Most colon cancer deaths are caused by the spread of tumor cells beyond the colon, usually to the liver. In a new study, MIT biologists identified a cellular pathway necessary for colorectal cancer metastasis.

24 Sep 2026

EGFR co-targeting and nanotechnology offer new triple-negative breast cancer therapies

Triple-negative breast cancer (TNBC) remains one of the most challenging forms of breast cancer to treat because it lacks the estrogen, progesterone and HER2 receptors that enable targeted treatment in other breast cancer subtypes.

24 Sep 2026

Protein modification network plays vital role in cancer development

A review published in Genes & Diseases highlights the complex interplay between protein arginine methylation and ubiquitination, two forms of protein modification that can profoundly influence cancer development, progression and treatment response.

24 Sep 2026

New trial aims to evaluate chemotherapy benefit for ER+/HER2- breast cancer patients

The addition of CDK4/6 inhibitors to endocrine therapy has changed the standard of care for patients with high-risk early-stage estrogen receptor-positive, HER2-negative (ER+/HER2-) breast cancer by reducing the risk of recurrence.

24 Sep 2026

Engineered nanoparticles sensitize gliomas to radiotherapy

Gliomas are a major cause of cancer-related deaths in younger adults.

24 Sep 2026

Cancer-related DNA changes may appear in blood years before diagnosis

Researchers found that genome-wide plasma cfDNA methylation profiles collected before diagnosis contained early molecular signatures associated with future prostate and breast cancer, with prostate silencer methylation providing the stronger risk stratification. Breast enhancer signals were weaker and varied by subtype and disease stage, indicating that cfDNA methylation may have greater value for risk assessment and surveillance than as a standalone diagnostic test.

23 Sep 2026

What links smoking, body fat, mental health, genes, and heart risk? Inflammation may be part of the answer

In a large UK Biobank study, higher levels of the chronic inflammation marker GlycA were associated with smaller heart chambers, thicker heart walls, impaired diastolic function, reduced stroke volume, and a 43% higher risk of major adverse cardiovascular events in the highest versus lowest GlycA group. Genetic susceptibility also modified the associations between environmental exposures, inflammation, and cardiovascular risk, while inflammatory proteins in the IL-1, TNF, and IL-6 pathways statistically mediated several of these associations.

23 Sep 2026

Study identifies potential resistance mechanism in metastatic uveal melanoma

Uveal melanoma is a rare and aggressive cancer that starts inside the eye and often spreads to the liver. Few treatment options exist, and unlike some forms of skin melanoma which can respond well to modern therapies, metastatic uveal melanoma (MUM) remains difficult to treat.

22 Sep 2026

New scanning method detects basal cell carcinoma early using AI

Researchers at FAU combine optical diagnosis method with AI-assisted image recognition.

22 Sep 2026

Binghamton University scientists win seed funding for medical technologies

Two Binghamton University faculty members will receive seed funding through the State University of New York (SUNY) Technology Accelerator Fund (TAF), which provides grants to faculty inventors and scientists.

22 Sep 2026

City of Hope develops adaptive plug-and-play CAR T technology to attack tumors

Researchers from City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the country, have developed a new "plug-and-play" technology that adds engineered molecules to chimeric antigen receptor (CAR) T cells after treatment, allowing scientists to better control the cells and redirect them to attack different types of cancer.

22 Sep 2026

Chronic DNA damage response may contribute to biological aging

A new review was published in Volume 18 of Aging on August 31, 2026, titled "The guardian paradox: DNA damage response overactivation as an integrative driver of aging – a tumor suppressor–negative regulator framework."

21 Sep 2026

Older adults with higher polyphenol intake were less likely to have mild cognitive impairment

In a cross-sectional study of 92 older Italian memory-clinic patients, higher habitual intake of total dietary (poly)phenols and several specific subclasses was associated with a lower likelihood of mild cognitive impairment (MCI). Total (poly)phenol intake was not associated with cognitive test performance or circulating inflammatory biomarkers, and the authors cautioned that the small observational study cannot establish causality.

20 Sep 2026

Y chromosome loss creates hidden cancer vulnerability in men

A study initiated by a University of Arizona Cancer Center physician-scientist Dr. Dan Theodorescu revealed that the loss of the Y chromosome in men's body tissue could pave the way for cancer to develop in that tissue.

18 Sep 2026

Scientists discover metabolite fueling aggressive brain tumor growth

Virtually all high-grade, aggressive gliomas in adults accumulate massive amounts of a metabolite called guanidinoacetate (GAA) that overstimulates nearby neurons and promotes tumor growth, according to new research from scientists at Children’s Medical Center Research Institute at UT Southwestern (CRI) published in Cell.

18 Sep 2026