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New framework maps the complex link between psychological status and cardiovascular health

CVD remains the leading cause of death worldwide, while the global burden of mental disorders continues to rise.

28 Sep 2026

Study links insomnia to higher stroke and hospitalization risks

Insomnia is associated with a 26% higher risk of stroke and 28% higher odds of hospital admission, according to new research in Sleep Medicine Reviews. The researchers say the findings support recognizing insomnia as an important marker of brain, mental and general health.

28 Sep 2026

An AI-identified biomarker can look accurate and still fail its biggest test

The review examines how AI combines molecular, imaging, circulating, cellular, and digital data to identify potential disease biomarkers. Its authors argue that independent validation, biological testing, and evidence of better clinical decisions are needed before those candidates enter patient care.

28 Sep 2026

Semaglutide cuts major heart events, but researchers still cannot fully explain why

In adults with overweight or obesity and established cardiovascular disease but no diabetes, semaglutide reduced major adverse cardiovascular events by 20%, while changes in measured cardiovascular risk factors could not fully explain the benefit with certainty. The findings suggest that additional, as-yet unidentified biological pathways may contribute to semaglutide’s cardiovascular protection.

27 Sep 2026

Could the Mediterranean diet protect the brain through the gut?

A narrative review finds that the Mediterranean diet may support brain health through gut microbiome, immune, metabolic, and barrier-related pathways, but direct human evidence that microbiome remodeling mediates neuroprotection remains limited. The proposed mechanisms involve microbial metabolites, reduced inflammatory signaling, stronger intestinal and blood-brain barrier function, and possible effects on processes linked to Alzheimer’s and Parkinson’s diseases.

27 Sep 2026

Heated tobacco users had more hypertension, but the story is not that simple

A large Japanese real-world cohort study found that current heated tobacco product users had a higher risk of developing hypertension than never-smokers in the primary adjusted analysis. However, the association weakened in several sensitivity analyses, and the observational study could not separate the effects of current heated tobacco use from previous cigarette exposure.

27 Sep 2026

Common anti-epileptic medication shows promise in reducing migraine aura

A new study by researchers at Lund University in Sweden found that 85 percent of patients with aura-dominant migraine experienced a reduction in monthly aura days by at least half following treatment with the anti-epileptic drug lamotrigine.

25 Sep 2026

Mount Sinai researchers discover how Alzheimer's gene damages blood vessels

Mount Sinai researchers have identified how APOE4, the strongest genetic risk factor for Alzheimer's disease, damages the brain's blood vessels and promotes the buildup of abnormal proteins linked to neurodegenerative disease.

24 Sep 2026

Semaglutide’s heart benefits may extend beyond weight loss

Semaglutide is known to reduce the risk of serious heart disease. However, a new study published in the European Heart Journal today (Thursday) suggests that this effect cannot not be entirely explained by patients losing weight on the drug.

23 Sep 2026

Transient ischemic attacks linked to increased long-term dementia risk

Having a transient ischemic attack (TIA) is associated with an increased risk of developing dementia, according to a new study published September 23, 2026, in Neurology, the medical journal of the American Academy of Neurology.

23 Sep 2026

PsychAD studies map molecular mechanisms across major brain disorders

Research led by Mount Sinai scientists within the PsychAD Consortium, a large-scale, multidisciplinary initiative launched in 2019 with support from the National Institute on Aging (NIA), is featured in a landmark collection of nine papers published across the Nature family of journals that maps the molecular mechanisms underlying Alzheimer's disease, Parkinson's disease, schizophrenia, and other brain disorders.

23 Sep 2026

Menopause leaves a blood protein signature linked to brain aging and Alzheimer’s risk

Researchers identified a 16-protein blood signature associated with menopause that tracked more strongly with reproductive hormones than chronological age and was largely replicated in an independent UK Biobank cohort. Higher menopause proteomic scores were also associated with less favorable proteomic aging estimates and poorer cognitive outcomes in older women, including incident Alzheimer’s dementia, although the observational evidence does not establish causality.

23 Sep 2026

Screening approved medicines reveals potential treatments for preterm labor

Shajila Siricilla, PhD, Assistant Professor of Pediatrics, and Jennifer Herington, PhD, Associate Professor of Pediatrics, led a team that systematically screened 1,191 FDA-approved drugs and found that several candidates met criteria supporting further evaluation as potential treatments for preterm labor.

23 Sep 2026

C-Path awards $1.7 million to advance five drug development projects

Critical Path Institute (C-Path) today announced that its Translational Therapeutics Accelerator has awarded $1,699,500 through five Bridging Research and Innovation in Drug Development Grants (BRIDGe).

22 Sep 2026

The FFS (Fight Fibrin Sheath) campaign launches to improve patient lives by tackling dialysis catheters' most common dysfunction

An international coalition of vascular access surgeons, nephrologists, researchers and industry partners today launched the Fight Fibrin Sheath (FFS) campaign, a clinician-led action group working collaboratively to advance research, education and innovation relating to fibrin sheath formation, and to improve vascular access outcomes for dialysis patients worldwide.

22 Sep 2026

Older adults with higher polyphenol intake were less likely to have mild cognitive impairment

In a cross-sectional study of 92 older Italian memory-clinic patients, higher habitual intake of total dietary (poly)phenols and several specific subclasses was associated with a lower likelihood of mild cognitive impairment (MCI). Total (poly)phenol intake was not associated with cognitive test performance or circulating inflammatory biomarkers, and the authors cautioned that the small observational study cannot establish causality.

20 Sep 2026

New white paper calls for integrating oral and general healthcare

Oral health can no longer be treated separately from general health, according to a new white paper from the European Federation of Periodontology (EFP) and the European Association of Dental Public Health (EADPH) which calls for closer collaboration between dental, medical, public-health and social-care professionals.

18 Sep 2026

Better fitness was linked to healthier brain structure, but not better memory

Researchers studying 353 cognitively unimpaired adults aged 60 to 94 found that higher muscular capacity was associated with lower basal ganglia perivascular space volume, while greater aerobic fitness was associated with greater gray matter volume and medial temporal lobe thickness. Fitness was not directly associated with global cognition or episodic memory, and evidence for cognitive reserve was limited, although VO₂max explained additional variation in delayed verbal memory beyond tau burden.

18 Sep 2026

CGM reveals glucose patterns linked to cardiometabolic risk in adults without diabetes

Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are the clinical gold standards for screening for blood sugar levels yet they provide only static snapshots that fail to reflect the highly dynamic and heterogeneous nature of metabolic impairment.

17 Sep 2026

New clinical guidelines standardize kidney replacement therapy in ICU patients

Acute kidney injury (AKI) is a common and severe complication in the intensive care unit (ICU). Due to its high incidence, strong correlation with poor prognosis, and substantial consumption of medical resources, AKI has become one of the central challenges in modern critical care medicine.

17 Sep 2026