p53 Protein News and Research

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The TP53 is a gene that instructs the cell to produce tumor protein (p53) ; a vital transcription factor and tumor suppressor. P53 is known as the “guardian of the genome” as it helps in regulating the cell cycle and acts as a tumor suppressor.

New study reveals genetic drivers of inherited bone marrow failure syndrome

Inherited bone marrow failure syndrome, or IBMFS, describes a group of disorders in which inherited genetic abnormalities impair the bone marrow's ability to produce sufficient healthy blood cells.

6 Aug 2026

Brain cell division errors may drive cancer and developmental disorders

University of Virginia School of Medicine scientists have revealed how mistakes in the final step of cell division can have dire consequences for developing brain cells.

20 May 2026

Single-cell technique maps pre-malignant gene mutations in solid tissues

A new single-cell profiling technique has mapped pre-malignant gene mutations and their effects in solid tissues for the first time, in a study led by investigators at Weill Cornell Medicine and the New York Genome Center.

16 Jan 2026

Australian scientists uncover new way to halt aggressive cancer growth

Australian researchers have discovered a promising new strategy to suppress the growth of aggressive and hard-to-treat cancers by targeting a specialized molecular process known as 'minor splicing'.

28 Jul 2025

Study finds key p53 targets for future cancer treatment

A new research paper was published in Oncotarget, Volume 16, on February 18, 2025, titled "Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells."

24 Feb 2025

p53 mutations show diverse impact on pancreatic cancer metabolism

A research team at the University of Konstanz, led by toxicologist Ivano Amelio, has demonstrated how differently individual mutations of the tumor suppressor p53 affect pancreatic carcinomas.

6 Dec 2024

Fas-p53 pathway drives metabolic dysfunction and obesity-linked insulin resistance

Researchers unveil Fas-p53 axis as a key regulator in adipocyte metabolism, linking it to obesity and insulin sensitivity through energy expenditure and inflammation pathways.

3 Dec 2024

Researchers uncover why the TP53 gene is especially prone to mutations in cancer

Mutations in the fragile TP53 gene impair p53's tumor-suppressive functions, making it more vulnerable than other tumor suppressors.

24 Oct 2024

Researchers gain new understanding of how immune cells respond to heat during fever

The study reveals that moderate fever enhances CD4 T cell activity while reducing regulatory T cell suppression, highlighting temperature's immune effects.

25 Sep 2024

MIT researchers develop new method to quickly screen cancer-associated genetic mutations

Tumors can carry mutations in hundreds of different genes, and each of those genes may be mutated in different ways - some mutations simply replace one DNA nucleotide with another, while others insert or delete larger sections of DNA.

12 Mar 2024

mRNA therapy revives p53 to combat ovarian tumors

Ovarian cancer is often very aggressive and responds poorly to the therapies currently available. A recent study by Goethe University Frankfurt and University Hospital Frankfurt offers hope that this could change in the medium term.

24 Jan 2024

TTUHSC researcher receives $1.76 million grant to investigate new pancreatic cancer treatment

With a survival rate in the single digits, pancreatic ductal adenocarcinoma (PDAC) is highly lethal. In fact, by the time PDAC is clinically diagnosed, it is already considered incurable via surgery or other means in up to 90% of patients.

2 Aug 2023

Wistar scientists uncover a key mechanism as to how p53 suppresses tumors

The p53 gene is one of the most important in the human genome: the only role of the p53 protein that this gene encodes is to sense when a tumor is forming and to kill it.

5 May 2023

Researchers discover and characterize a novel protein involved in tumor suppression mechanism

Understanding how cancer develops is critical for designing effective, personalized cancer therapies. Researchers have known for years that cancer begins with mutations in certain types of genes.

6 Apr 2023

Protein adduction and p53 tumor suppressor inhibition

Researchers assessed the impact of protein adduction on p53 tumor suppressor inhibition.

27 Jan 2023

New computation-guided approach to identify small molecule corrector drugs for p53 hotspot mutations

A new study, led by researchers from the University of California, Irvine and the University of California, San Diego, reveals a new computation-guided approach to identify small molecules that can restore aspects of wild-type p53 tumor suppression function to mutated p53, which play an important role in many human cancers.

11 Aug 2022

Queen’s researchers receive grant from Breast Cancer Now to search for new treatments

Researchers at Queen's University Belfast have received funding from Breast Cancer Now to search for new treatments inspired by COVID-19 vaccine innovation.

3 Aug 2022

Elephant genes could offer new clues to preventing cancer development

Scientists modeling the cancer-suppressing p53 gene identify how the 20 different molecules unique to elephants get activated for increased sensitivity and response against carcinogenic conditions - with implications for cancer treatments in humans.

19 Jul 2022

Researchers find unusual way of stabilizing cancer-suppressing protein

The p53 protein protects our cells from cancer and is an interesting target for cancer treatments. The problem is, however, that it breaks down rapidly in the cell. Researchers at Karolinska Institutet in Sweden have now found an unusual way of stabilizing the protein and making it more potent.

14 Mar 2022

Research reveals key role of p53 protein in epithelial migration and tissue repair

New research led by the University of Bristol has found the protein p53 plays a key role in epithelial migration and tissue repair.

11 Feb 2022