Antiretroviral News and Research

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Phase 2 clinical trial launched in Thailand to evaluate IL-15 agonist as therapy to reduce HIV reservoir

The U.S. Military HIV Research Program (MHRP) at the Walter Reed Army Institute of Research last week launched a Phase 2 clinical trial in Thailand to evaluate an interleukin-15 (IL-15) superagonist, ImmunityBio's Anktiva (also called N-803), administered during acute HIV infection as an experimental therapy to target establishment of the HIV reservoir at a very early stage.

8 Apr 2021

Vaccine nationalism reinforces inequities in access and exacerbates health disparities

While the U.S. has begun to vaccinate millions of Americans each day, COVID-19 vaccine supplies around the world remain scarce.

5 Apr 2021

Diabetes drug appears to exploit vulnerability of AIDS-causing retrovirus HIV

A team led by scientists at the UNC School of Medicine discovered an important vulnerability of the AIDS-causing retrovirus HIV, and has shown in preclinical experiments that a widely used diabetes drug, metformin, seems able to exploit this vulnerability.

29 Mar 2021

Researchers identify chemicals that keep HIV virus in dormant state

When the human immunodeficiency virus infects cells, it can either exploit the cells to start making more copies of itself or remain dormant--a phenomenon called latency.

24 Mar 2021

New guidelines outline key new actions to improve delivery of HIV testing, treatment and care

These guidelines provide new and updated recommendations on the use of point-of-care testing in children under 18 months of age and point-of-care tests to monitor treatment in people living with HIV; the treatment monitoring algorithm; and timing of antiretroviral therapy (ART) among people living with HIV who are being treated for tuberculosis.

23 Mar 2021

Antidiabetic drug could help reduce chronic inflammation in people living with HIV

Metformin, a drug used to treat type-2 diabetes, could help reduce chronic inflammation in people living with HIV (PLWH) who are being treated with antiretroviral therapy (ART), according to researchers at the University of Montreal Hospital Research Centre.

18 Mar 2021

Abbott Pandemic Defence Coalition aims to identify new viral threats and take quick action

Abbott today announced the formation of the Abbott Pandemic Defence Coalition, a first-of-its-kind global scientific and public health partnership dedicated to the early detection of, and rapid response to, future pandemic threats.

17 Mar 2021

Online platforms can increase drug overdose

HSE University researchers together with specialists from the Humanitarian Action Charitable Fund (St. Petersburg) and the University of Michigan School of Public Health (USA) studied the specifics of remote work with Russian people who use drugs to reduce the harm of drug use.

16 Mar 2021

Home delivery of HIV medicines could increase ART adherence, viral suppression

Home delivery of HIV medicines in South Africa significantly increased viral suppression compared to those who received clinical care, according to a study by researchers at the University of Washington School of Medicine.

10 Mar 2021

Inflammation linked to intensity of tobacco smoking among HIV-positive people

Inflammation in the body has been linked to the intensity of tobacco smoking among people with HIV, according to a team of University of Massachusetts Amherst researchers.

8 Mar 2021

Experimental therapy delays viral rebound in SHIV-infected macaques

A recent preclinical study by U.S. Military HIV Research Program (MHRP) researchers showed that an experimental therapy combining a TLR7 agonist and two broadly neutralizing antibodies delayed viral rebound in SHIV-infected macaques after antiretroviral therapy (ART) interruption.

2 Mar 2021

Protein kinase inhibitors could help treat immunodeficiency in HIV patients

HIV infections are treated with antiviral drugs which effectively prevent the disease from developing. While pharmacological HIV therapy has advanced considerably, the virus cannot be entirely eliminated from the body with currently available drugs.

1 Mar 2021

Study explores the effects of COVID-19 on Black and Latino individuals living with HIV

With the COVID-19 pandemic taking a disproportionate toll on low-income people of color, a research team headed by Marya Gwadz of the Silver School of Social Work at New York University set out to understand the ways the pandemic may put individuals at risk for adverse outcomes, and the ways they successfully adapted to and coped with the emerging pandemic, focused on those from low-socioeconomic status backgrounds who have lived with HIV for a decade or longer.

22 Feb 2021

HIV-positive people with severe immunosuppression, APOE4 gene may have increased risk for dementia

People living with the human immunodeficiency virus (HIV) who have a history of severe immunosuppression and at least one copy of the Alzheimer's disease-related gene variant APOE4, might see a compounded adverse effect on the circuitry that impacts memory.

22 Feb 2021

Antimicrobial resistance to critical drugs spirals in low- and middle-income countries

As antibiotic use grows in lower-income countries so does antibiotic resistance, says report.

20 Feb 2021

New research yields potential drug target against HIV

Humans possess a formidable multi-layered defense system that protects us against viral infections. Better understanding of these defenses and the tricks that viruses use to evade them could open novel avenues for treating viral infections and possibly other diseases.

11 Feb 2021

HIV: New therapeutic approach to restore the effectiveness of immune cells

Prompted by the need to improve conventional treatments for people infected with the human immunodeficiency virus (HIV-1), a team from the Institut national de la recherche scientifique has identified a therapeutic approach to restore the effectiveness of immune cells.

8 Feb 2021

Researchers report trial results of rectal microbicides at HIV R4P Virtual Conference

Researchers seeking to develop on-demand and behaviorally congruent HIV prevention options for people who practice anal sex are reporting the results of three early phase clinical trials of rectal microbicides at this week's HIV Research for Prevention (HIV R4P) Virtual Conference.

3 Feb 2021

WHO recommends dapivirine vaginal ring as additional HIV prevention choice for at-risk women

WHO today recommended that the dapivirine vaginal ring (DPV-VR) may be offered as an additional prevention choice for women at substantial risk of HIV infection as part of combination prevention approaches.

1 Feb 2021

Use of antiviral and antiretroviral medication could have detrimental impact on crops

The increased global use of antiviral and antiretroviral medication could have a detrimental impact on crops and potentially heighten resistance to their effects, new research has suggested.

29 Jan 2021