Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Adding veliparib to chemotherapy can extend progression-free survival in patients with “BRCA-like” breast cancer

Results from the SWOG S1416 clinical trial show that adding veliparib to chemotherapy can significantly extend progression-free survival (PFS) times in patients with triple-negative breast cancer (TNBC) that has a "BRCA-like" phenotype.

31 Jan 2023

A machine-learning approach to identify asthma subtypes based on molecular signatures

Researchers determine whether protein expression in nasal fluid samples could assist in the diagnosis of severe asthma subtypes.

31 Jan 2023

Focused-ultrasound-mediated liquid biopsy improves detection of neurodegeneration biomarkers

Several progressive neurodegenerative disorders, including Alzheimer's disease, are defined by having tau proteins in the brain.

31 Jan 2023

Impaired glucose tolerance and cardiovascular risk factors associated with fertility problems

The present study provided strong evidence that supported the hypothesis that hyperinsulinemia and glucose intolerance cause infertility in women.

31 Jan 2023

Doctoral research presents predictive value of biomarkers for inflammatory bowel diseases

Under the supervision of four professors from the UMCG departments of Gastroenterology and Hepatology and Pathology and Medical Biology, Bourgonje conducted doctoral research on the predictive value of biomarkers for inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis.

29 Jan 2023

Researchers identify an unexpected driver of cancer immunotherapy resistance

A research team from the LKS Faculty of Medicine, the University of Hong Kong (HKUMed) has identified an unexpected driver of cancer immunotherapy resistance: the harmful effect of chronic Type I Interferon signaling on tumor-killing CD8+ T cells.

27 Jan 2023

Persistent tumor mutation burden linked with therapeutic response to immunotherapy

Cancer experts have tried, sometimes unsuccessfully, to use the total number of mutations in a tumor, called the tumor mutation burden (TMB), to predict a patient's response to immunotherapy.

26 Jan 2023

Researchers develop a new multi-omics microsampling method for complete health profiling

Researchers developed a multi-omics-based microsampling workflow for profiling proteins, metabolites, lipids, and specific cytokines and hormones, i.e., multiple analytes, in a single blood sample of 10 μl (microsample).

26 Jan 2023

Scientists reveal how genetic changes lead to differences in the size of cancer cells

Cancer cells can shrink or super-size themselves to survive drug treatment or other challenges within their environment, researchers have discovered.

25 Jan 2023

Researchers review the association between endogenous retrovirus reactivation and aging

Researchers explored the role of endogenous retrovirus (ERV) reactivation in the aging process.

24 Jan 2023

High adherence to procalcitonin-guided antibiotic prescribing guideline may reduce antibiotic use in hospitals

A study published in the journal BMC Infectious Diseases claims that high adherence to procalcitonin-guided antibiotic prescribing guidelines is necessary to reduce antibiotic use in patients with suspected lower respiratory tract infections.

23 Jan 2023

How does the brain change with age?

Researchers discussed cellular hallmarks of brain aging and therapeutic interventions to rejuvenate cognitive brain functions.

19 Jan 2023

Partial genetic reprogramming might extend lifespan and reverse aging in old mice

Researchers performed age-reversing experiments, in vivo and in vitro, in progeroid mice using gene therapy.

19 Jan 2023

Research explores the utility of epigenetically predicted BMI

DNA methylation is an accurate predictor of current BMI and a poor predictor of future BMI.

18 Jan 2023

Epigenetic alternations associated with common genital malformation in male babies

An alarming increase in the occurrence of the most common genital malformation in male babies, hypospadias, is likely due to environmental factors, such as toxicant exposure, which alter epigenetic programming in a forming penis.

18 Jan 2023

What are the major findings of long COVID research?

Researchers explored existing literature on long coronavirus disease (COVID). They highlighted key immunological findings, similarities with other diseases, symptoms, and associated pathophysiological mechanisms, and diagnostic and therapeutic options, including COVID-19 vaccinations.

17 Jan 2023

Protein heat shock transcription factor 1 may be a viable therapeutic target for hepatoblastoma

Although rare compared to adult liver cancers, hepatoblastoma is the most common pediatric liver malignancy, and its incidence is increasing.

16 Jan 2023

New blood test tracks neurodegenerative changes specifically in Alzheimer's disease

A new blood test that can track and follow the neurodegeneration in Alzheimer's disease - and exclude other dementias.

16 Jan 2023

The loss of epigenetic information accelerates the aging process

A new study in the journal Cell aimed to determine whether epigenetic changes are a cause of mammalian aging.

15 Jan 2023

Participants using Huma's clinical trial platform have high levels of engagement in COVID-19 study

Huma Therapeutics Limited ("Huma"), a leading global digital health company, today announced results of a new study in collaboration with the Medical Research Council Epidemiology Unit at the University of Cambridge showing that participants using Huma's clinical trial platform had high, sustained levels of engagement in an observational, fully remote COVID-19 study.

13 Jan 2023

Biomarker News and Research

Further Reading

Adding veliparib to chemotherapy can extend progression-free survival in patients with “BRCA-like” breast cancer

A machine-learning approach to identify asthma subtypes based on molecular signatures

Focused-ultrasound-mediated liquid biopsy improves detection of neurodegeneration biomarkers

Impaired glucose tolerance and cardiovascular risk factors associated with fertility problems

Doctoral research presents predictive value of biomarkers for inflammatory bowel diseases

Researchers identify an unexpected driver of cancer immunotherapy resistance

Persistent tumor mutation burden linked with therapeutic response to immunotherapy

Researchers develop a new multi-omics microsampling method for complete health profiling

Scientists reveal how genetic changes lead to differences in the size of cancer cells

Researchers review the association between endogenous retrovirus reactivation and aging

High adherence to procalcitonin-guided antibiotic prescribing guideline may reduce antibiotic use in hospitals

How does the brain change with age?

Partial genetic reprogramming might extend lifespan and reverse aging in old mice

Research explores the utility of epigenetically predicted BMI

Epigenetic alternations associated with common genital malformation in male babies

What are the major findings of long COVID research?

Protein heat shock transcription factor 1 may be a viable therapeutic target for hepatoblastoma

New blood test tracks neurodegenerative changes specifically in Alzheimer's disease

The loss of epigenetic information accelerates the aging process

Participants using Huma's clinical trial platform have high levels of engagement in COVID-19 study

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