Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Pharmaceutical, biotechnology and drug discovery companies are increasingly turning their attention to cell-based assays

Pharmaceutical, biotechnology and drug discovery companies are increasingly turning their attention to cell-based assays, as these assays offer a more accurate representation of the real-life cell model than the traditional enzyme- or antibody-based assays.

13 Dec 2004

Wide angle X-ray scattering (WAXS) could help produce lead drugs for disease therapy

Structural changes in proteins can now be seen in increased detail, using a new application of an existing technique. The application, developed at the U.S. Department of Energy's Argonne National Laboratory, could help produce lead drugs for disease therapy.

8 Dec 2004

Escalating costs and lengthy clinical trials are major concerns for researchers in the field of drug discovery

Escalating costs and lengthy clinical trials are major concerns for researchers attempting to boost productivity and efficiency in the field of drug discovery. Biomarkers are emerging as the solution to these problems with their ability to reduce drug development costs and time.

7 Dec 2004

Positive results from phase 2 trial of Telintra, drug candidate in myelodysplastic syndrome

Telik, Inc. reported positive interim data from a Phase 2 trial of its Telintra (TLK199) drug candidate in myelodysplastic syndrome (MDS). The data were reported in two presentations at the annual meeting of the American Society of Hematology in San Diego.

5 Dec 2004

Biopharmaceuticals industry, a rapidly growing sector within the pharmaceuticals industry

Global manufacturing of biopharmaceuticals has increased significantly over the last decade due to a number of reasons. Biopharmaceuticals offer several advantages such as highly effective and potent action, fewer side effects and the potential to actually cure diseases rather than merely treat the symptoms.

30 Nov 2004

Study links a novel protein pathway to the aggressive progression of breast cancer

Cytogen Corporation today announced the publication of a study linking a novel protein pathway to the aggressive progression of breast cancer.

24 Nov 2004

Crystals may help to revolutionise drug discovery

A groundbreaking technique developed at The University of Manchester, which uses crystals to map ‘invisible’ parts of molecules, is set to revolutionise drug discovery.

From The University of Manchester 24 Nov 2004

Marie Curie Cancer Care and Cancer Research Technology extend relationship for cancer patient benefit

Cancer Research Technology Limited (CRT), the specialist oncology focussed technology transfer and development company, today announced the completion of a Technology Transfer Agreement with Marie Curie Cancer Care, one of the largest cancer charities in the UK.

2 Nov 2004

Micro-array technology is revolutionising current drug development

Gene expression micro-array technology is benefiting all phases of the discovery, development and subsequent use of new cancer therapeutics

29 Oct 2004

Stem cells and drug design

Victorian College of Pharmacy researchers hope stem cells will help them better understand the action of existing drugs and aid in the discovery of new drugs for illnesses such as depression, obesity and anxiety.

5 Oct 2004

New national resource for medical researchers to be known as the Center on Proteolytic Pathways

The National Institutes of Health (“NIH”) has selected The Burnham Institute to develop a national resource for medical researchers to be known as the “Center on Proteolytic Pathways”.

4 Oct 2004

Microfluidics help lab-on-a-chip development skyrocket

Lab-on-a-chip (LOC) development has skyrocketed in the last couple of years due to constant efforts in harnessing microfluidics and µTAS to improve the LOC design and function. The distinct advantages that they bestow on applications are pushing the commercial potential of LOCs.

28 Sep 2004

Bionomics licences childhood epilepsy test

Bionomics has announced that it has granted a licence to Massachusetts-based Athena Diagnostics to market Bionomics’ childhood epilepsy diagnostic to neurologists in North America and Japan.

27 Sep 2004

Isis Pharmaceuticals licenses second anti-cancer drug candidate to Lilly

Isis Pharmaceuticals announced today that Eli Lilly and Company licensed LY2275796, a second-generation antisense anti-cancer drug candidate for clinical development.

20 Sep 2004

Existing hepatitis drug could lead to the development of new drugs for the treatment of anthrax

Thanks to new screening tools, and some luck, researchers at the University of Chicago have discovered three unrelated compounds that inhibit the two toxins – edema factor and lethal factor -- that have made anthrax one of the most feared of potential bioterror agents.

21 Aug 2004

New biotech alliance to focus on diseases of nerve injury and pain

NeuroTargets Ltd, a discovery-led biotechnology company ‘spun-out’ from the University of Bristol, has formed an exciting new alliance with BioFocus plc, a world leader in collaborative drug discovery, to focus on diseases of nerve injury and pain.

11 Aug 2004

IBM and Cellomics offer new solution to accelerate cell-based drug discovery

IBM and Cellomics have announced they have launched a customized information technology (IT) solution that allows biopharmaceutical scientists and academic researchers to better understand how potential drug candidates or targets of interest affect cellular function.

11 Aug 2004

Drug Discovery News and Research

Further Reading

Pharmaceutical, biotechnology and drug discovery companies are increasingly turning their attention to cell-based assays

Wide angle X-ray scattering (WAXS) could help produce lead drugs for disease therapy

Escalating costs and lengthy clinical trials are major concerns for researchers in the field of drug discovery

Positive results from phase 2 trial of Telintra, drug candidate in myelodysplastic syndrome

Biopharmaceuticals industry, a rapidly growing sector within the pharmaceuticals industry

Study links a novel protein pathway to the aggressive progression of breast cancer

Crystals may help to revolutionise drug discovery

Marie Curie Cancer Care and Cancer Research Technology extend relationship for cancer patient benefit

Micro-array technology is revolutionising current drug development

Stem cells and drug design

New national resource for medical researchers to be known as the Center on Proteolytic Pathways

Microfluidics help lab-on-a-chip development skyrocket

Bionomics licences childhood epilepsy test

Isis Pharmaceuticals licenses second anti-cancer drug candidate to Lilly

Existing hepatitis drug could lead to the development of new drugs for the treatment of anthrax

New biotech alliance to focus on diseases of nerve injury and pain

IBM and Cellomics offer new solution to accelerate cell-based drug discovery

Effects of oxidative stress on atherosclerosis

Cyntellect issued patent covering LaserFect(TM) technology

Research collaboration to discover novel oral drugs for the treatment of viral infections

Drug Discovery - Second Edition eBook

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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