Huntington's Disease News and Research

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Huntington's disease (HD) results from genetically programmed degeneration of brain cells, called neurons, in certain areas of the brain. This degeneration causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance. HD is a familial disease, passed from parent to child through a mutation in the normal gene. Each child of an HD parent has a 50-50 chance of inheriting the HD gene. If a child does not inherit the HD gene, he or she will not develop the disease and cannot pass it to subsequent generations. A person who inherits the HD gene will sooner or later develop the disease. Whether one child inherits the gene has no bearing on whether others will or will not inherit the gene. Some early symptoms of HD are mood swings, depression, irritability or trouble driving, learning new things, remembering a fact, or making a decision. As the disease progresses, concentration on intellectual tasks becomes increasingly difficult and the patient may have difficulty feeding himself or herself and swallowing. The rate of disease progression and the age of onset vary from person to person. A genetic test, coupled with a complete medical history and neurological and laboratory tests, helps physicians diagnose HD. Presymptomic testing is available for individuals who are at risk for carrying the HD gene. In 1 to 3 percent of individuals with HD, no family history of HD can be found.
Adult-onset degenerative disease mechanism begins much earlier than previously thought

Adult-onset degenerative disease mechanism begins much earlier than previously thought

C-Path and CHDI announce launch of Huntington's Disease Regulatory Science Consortium

C-Path and CHDI announce launch of Huntington's Disease Regulatory Science Consortium

Golgi stress signaling pathway found in cells with Huntington’s disease

Golgi stress signaling pathway found in cells with Huntington’s disease

Scientists decode molecular structure of healthy huntingtin protein

Scientists decode molecular structure of healthy huntingtin protein

Patients with Huntington's have lesser cancer than general population

Patients with Huntington's have lesser cancer than general population

UNC gene therapy scientists uncover viral barcode to penetrate blood-brain barrier

UNC gene therapy scientists uncover viral barcode to penetrate blood-brain barrier

The effects of Huntington’s disease can be seen as early as conception, finds new study

The effects of Huntington’s disease can be seen as early as conception, finds new study

Rockefeller scientists develop system to model Huntington’s in human embryonic stem cells

Rockefeller scientists develop system to model Huntington’s in human embryonic stem cells

Researchers uncover key protein that rescues progression of adult spinocerebellar ataxia

Researchers uncover key protein that rescues progression of adult spinocerebellar ataxia

Study finds overall pattern of commonality between Huntington's and Parkinson's

Study finds overall pattern of commonality between Huntington's and Parkinson's

Sangamo and Pfizer partner for development of new zinc finger protein gene therapy to treat ALS

Sangamo and Pfizer partner for development of new zinc finger protein gene therapy to treat ALS

Discovery of potential biomarker for Huntington's disease may help postpone disease onset

Discovery of potential biomarker for Huntington's disease may help postpone disease onset

Portable technique produces rapid blink measurements for assessing neurological function

Portable technique produces rapid blink measurements for assessing neurological function

Newly discovered molecular chaperones may soon be part of therapies for Huntington's disease

Newly discovered molecular chaperones may soon be part of therapies for Huntington's disease

Huntington's disease drug clears initial hurdles - raising hopes

Huntington's disease drug clears initial hurdles - raising hopes

Research brings scientists one step closer to understanding development of ALS

Research brings scientists one step closer to understanding development of ALS

Huntington's patients need better communication around assisted dying, study shows

Huntington's patients need better communication around assisted dying, study shows

Early intervention may be crucial to successful treatment of Friedreich's ataxia

Early intervention may be crucial to successful treatment of Friedreich's ataxia

IMB researchers unveil mystery of aging process

IMB researchers unveil mystery of aging process

IMB researchers make breakthrough in understanding origin of aging process

IMB researchers make breakthrough in understanding origin of aging process