Interleukin 4 News and Research

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Role of M2 macrophage-derived exosomes in controlling neutrophil-mediated tissue injury in sepsis

Researchers investigate whether M2 macrophage-derived exosomes could prevent inflammation-associated damage during sepsis.

7 Aug 2023

Prolonged T-cell response during severe COVID-19 does not contribute to long COVID

Persistent immune activation and elevated cytokine levels were observed in patients with severe COVID-19, even months after recovery. However, the correlation between immune activation and long COVID symptoms appeared to be independent, suggesting other factors influencing disease severity.

9 Jul 2023

Battle against RSV: Computational design paves way for new polyvalent vaccine

Research focuses on the design of a multi-epitope polyvalent vaccine against Human Respiratory Syncytial Virus (RSV), a leading cause of lower respiratory tract infections. The study utilizes computational methods and immunoinformatics tools to predict potential vaccine candidates and their interactions with Toll-like receptors (TLRs).

19 Jun 2023

NIH sponsors the trial of monoclonal antibody to prevent asthma exacerbations in urban youth

The National Institutes of Health has launched a clinical trial testing whether a monoclonal antibody, dupilumab, can reduce asthma attacks and improve lung function and asthma symptoms in children with poorly controlled allergic asthma who live in low-income urban neighborhoods.

2 Jun 2022

Newly discovered cell type makes survivors of sepsis more vulnerable to infections

Sepsis is the leading cause of death in Brazil's intensive care units (ICUs). Among patients who progress to the severe form of the disease, 40% die, and the survivors often suffer from cardiovascular and neurological complications, as well as a significant decline in immunity lasting for years after they are discharged from hospital.

2 Sep 2021

Implanted cells deliver a biologic drug in response to inflammation in rheumatoid arthritis

With a goal of developing rheumatoid arthritis therapies with minimal side effects, researchers at Washington University School of Medicine in St. Louis have genetically engineered cells that, when implanted in mice, will deliver a biologic drug in response to inflammation.

1 Sep 2021

Attenuated virulence and protective immunity in SARS-CoV-2 with a mutation in the S1/S2 cleavage site

A new study published in mBio investigates the impact of the furin cleavage site on viral growth and pathogenesis.

31 Aug 2021

DNMT2/TRDMT1 gene knockout may potentiate adverse effects related to drug-induced senescence

Aging-US published "The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence" which reported that cellular senescence may be a side effect of chemotherapy and other anti-cancer treatments that may promote inflammation and paracrine secondary senescence in healthy tissues.

31 Aug 2021

The impact of mild SARS-CoV-2 infection on maternal-fetal immunity

Recently, a new study published on the pre-print server bioRxiv* examined the effect that maternal asymptomatic COVID-19 had on decidual and peripheral immune cells during the later stage of pregnancy.

30 Aug 2021

Polymeric and lipid nanoparticles in self-amplifying RNA vaccines result in higher protein expression and immunogenicity

Self-amplifying RNA (saRNA) is an advanced platform for nucleic acid vaccine development. The backbone is typically derived from an alphaviral genome and encodes a gene of interest (GOI) and a viral replicase that can amplify the genomic and subgenomic RNA.

30 Aug 2021

Next-gen COVID vaccine to make persistent neutralizing antibodies

Presently, there is a need to develop improved versions of COVID-19 vaccines that are effective against the SARS-CoV-2 variants of concern (VOC) and can confer long-term protection. Considering the need of the hour, scientists from the University of Sydney in Australia have generated a new COVID-19 vaccine CoVac-II and evaluated its effect against COVID-19 strains. The findings from this study are published on the bioRxiv* preprint server while awaiting peer review.

30 Aug 2021

Mild maternal infections can have permanent impacts on offspring immunity

During pregnancy, mild infections in the mother can have permanent and tissue-specific impacts on offspring immunity, according to a new study in mice.

27 Aug 2021

Could soluble CD24 offer some hope against severe COVID-19?

A recent randomized phase III trial conducted by researchers at the Ohio State University, Columbus, OH, US, evaluated the impact of CD24Fc in severe COVID-19 patients and showed promising clinical efficacy. This study is available as a preprint on the medRxiv* server.

26 Aug 2021

Glycyrrhizic acid as a drug candidate for COVID-19

A new study presents the benefits of licorice, an age-old herbal remedy, to treat COVID-19 at all stages.

24 Aug 2021

Does SARS-CoV-2 affect male fertility?

A recently published review describes the state of current knowledge regarding the impact of SARS-CoV-2 on the male reproductive system.

23 Aug 2021

Regular physical exercise modulates iron metabolism in Alzheimer’s mouse model

A recent experimental study shows how regular physical exercise modulates iron metabolism in both the brain and the muscles.

20 Aug 2021

SARS-CoV-2 ORF8 and the expression of cytokine in human macrophages

A new study has determined the production of the SARS-CoV-2 SP-dependent ORF8.

18 Aug 2021

Response to a third SARS-CoV-2 vaccine dose amongst immunocompromised

In a research paper recently uploaded to the preprint server medRxiv* by Schrezenmeier et al. (August 12th, 2021) the potential benefit of three vaccine doses in either a homogenous or heterogeneous dosing regimen amongst kidney transplant patients is assessed, finding that the search for viable vaccination approaches amongst these patients remains an urgent medical need.

16 Aug 2021

Plant-based virus-like particle vaccine induces durable immune response against SARS-CoV-2 variants

Scientists from Germany and Belgium have recently described the immunogenicity of a plant-based virus-like particle vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The vaccine induces robust antibody and T cell responses for at least 6 months. Moreover, the vaccine demonstrates potent neutralizing efficacy against the B.1.1.7, B.1.351, and P1 variants of SARS-CoV-2.

11 Aug 2021

New compound inspired by tapeworm drugs shows two-pronged effectiveness against COVID-19

A group of medications long prescribed to treat tapeworm has inspired a compound that shows two-pronged effectiveness against COVID-19 in laboratory studies, according to a new publication appearing online in the journal ACS Infectious Disease.

9 Aug 2021

Interleukin 4 News and Research

Role of M2 macrophage-derived exosomes in controlling neutrophil-mediated tissue injury in sepsis

Prolonged T-cell response during severe COVID-19 does not contribute to long COVID

Battle against RSV: Computational design paves way for new polyvalent vaccine

NIH sponsors the trial of monoclonal antibody to prevent asthma exacerbations in urban youth

Newly discovered cell type makes survivors of sepsis more vulnerable to infections

Implanted cells deliver a biologic drug in response to inflammation in rheumatoid arthritis

Attenuated virulence and protective immunity in SARS-CoV-2 with a mutation in the S1/S2 cleavage site

DNMT2/TRDMT1 gene knockout may potentiate adverse effects related to drug-induced senescence

The impact of mild SARS-CoV-2 infection on maternal-fetal immunity

Polymeric and lipid nanoparticles in self-amplifying RNA vaccines result in higher protein expression and immunogenicity

Next-gen COVID vaccine to make persistent neutralizing antibodies

Mild maternal infections can have permanent impacts on offspring immunity

Could soluble CD24 offer some hope against severe COVID-19?

Glycyrrhizic acid as a drug candidate for COVID-19

Does SARS-CoV-2 affect male fertility?

Regular physical exercise modulates iron metabolism in Alzheimer’s mouse model

SARS-CoV-2 ORF8 and the expression of cytokine in human macrophages

Response to a third SARS-CoV-2 vaccine dose amongst immunocompromised

Plant-based virus-like particle vaccine induces durable immune response against SARS-CoV-2 variants

New compound inspired by tapeworm drugs shows two-pronged effectiveness against COVID-19

Breaking Barriers: ANDYSMANCLUB's Fight for Men's Mental Health on World Mental Health Day

Arrayed CRISPR Screening for Revolutionizing Target Discovery

Innovations in baculovirus–insect cell expression systems

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