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Phosphatidic acid is a key common substrate for hepatitis C and SARS-CoV-2 replication

A new study, released as a preprint on the bioRxiv* server, focuses on the lipid molecule called phosphatidic acid (PA), showing its crucial role in the replication of this virus, and thus its potential as a target for therapeutic intervention.

13 May 2021

Absence of key gene causes severe hearing loss

A gene called GAS2 plays a key role in normal hearing, and its absence causes severe hearing loss, according to a study led by researchers in the Perelman School of Medicine at the University of Pennsylvania.

7 May 2021

Study suggests GILZ protein as a promising anti-hepatic fibrosis drug target

Scientists from Russia and Italy studied a new axis of the pathway that prevents the development of liver fibrosis. The role of GILZ protein in curbing the disease progression was shown in a study using mice models and confirmed by clinical data.

5 May 2021

SARS-CoV-2 limits type I and type III IFN protein biogenesis

New research led by Roy Parker of the University of Colorado Boulder finds that SARS-CoV-2 prevents the IFN response despite an increased presence of IFN-encoding mRNAs by suppressing transcriptional processes. Inhibition of IFN mRNAs triggers degradation from the activation of RNase L and the SARS-CoV-2 protein Nsp1.

26 Apr 2021

Regulatory protein in skeletal muscle fiber may play a key role in the body's fight or flight response

Researchers at the University of Cincinnati say a regulatory protein found in skeletal muscle fiber may play an important role in the body's fight or flight response when encountering stressful situations.

23 Apr 2021

Study discovers mechanism involved in the development of metaplasia in the esophagus

Metaplasia is defined as the replacement of a fully differentiated cell type by another. There are several classical examples of metaplasia, one of the most frequent is called Barrett's esophagus.

21 Apr 2021

Study reveals the mechanisms involved in the transdifferentiation of esophageal keratinocytes into columnar cells

Metaplasia is defined as the replacement of a fully differentiated cell type by another. There are several classical examples of metaplasia, one of the most frequent is called Barrett's oesophagus.

21 Apr 2021

Aged bone marrow niche restrains function of rejuvenated HSCs, shows study

When leukemia strikes an older person, it is in part due to the aging of his or her hematopoietic stem cells (HSCs).

13 Apr 2021

Researchers Identify potent small molecule inhibitors against SARS-CoV-2

A team of scientists from the USA and Sweden has recently screened 8 million small molecule inhibitors against SARS-CoV-2.

5 Apr 2021

Infliximab may hinder the effectiveness of some COVID-19 vaccines

A new study reports reduced vaccine efficacy following the use of a single COVID-19 vaccine dose in people who are on the immunosuppressive monoclonal antibody Infliximab.

31 Mar 2021

Prime editing enables more precise correction of genetic problems than traditional CRISPR

The latest gene editing technology, prime editing, expands the "genetic toolbox" for more precisely creating disease models and correcting genetic problems, scientists say.

30 Mar 2021

Study may provide an explanation for dawn phenomenon in patients with type 2 diabetes

Researchers at Baylor College of Medicine, Shandong University in China and other institutions may have found an explanation for dawn phenomenon, an abnormal increase of blood sugar only in the morning, observed in many patients with type 2 diabetes.

25 Mar 2021

New covalent and non-covalent SARS-CoV-2 inhibitors discovered in silico

A new study describes the use of a combination of virtual and experimental screening protocols to identify potential inhibitors of the virus, which could lead to rapid drug development.

24 Mar 2021

Scientists use ultrasound to map arrhythmic sites more accurately

Abnormal heart rhythms-; cardiac arrhythmias-; are a major worldwide health problem. Now scientists are using ultrasound for more accurate maps of arrhythmic sites in the heart for the improved success of ablation procedures.

24 Mar 2021

Speakers Announced for Virtual Experimental Biology 2021 Meeting

Renowned scientists—including Nobel laureates, research pioneers, and celebrated educators—will speak at the virtual Experimental Biology (EB) 2021 meeting, to be held April 27–30.

23 Mar 2021

YAP inhibitors could facilitate targeted treatment of basal-like breast cancer

Targeted treatment of basal-like breast cancer could be facilitated by YAP inhibitors in the future. As reported by an MDC team headed by Walter Birchmeier in the scientific journal Cancer Research, this type of cancer requires the support of the YAP protein to stimulate the growth of cancer stem cells.

22 Mar 2021

Knockout News and Research

Phosphatidic acid is a key common substrate for hepatitis C and SARS-CoV-2 replication

Absence of key gene causes severe hearing loss

Study suggests GILZ protein as a promising anti-hepatic fibrosis drug target

SARS-CoV-2 limits type I and type III IFN protein biogenesis

Regulatory protein in skeletal muscle fiber may play a key role in the body's fight or flight response

Study discovers mechanism involved in the development of metaplasia in the esophagus

Study reveals the mechanisms involved in the transdifferentiation of esophageal keratinocytes into columnar cells

Aged bone marrow niche restrains function of rejuvenated HSCs, shows study

Researchers Identify potent small molecule inhibitors against SARS-CoV-2

Infliximab may hinder the effectiveness of some COVID-19 vaccines

Prime editing enables more precise correction of genetic problems than traditional CRISPR

Study may provide an explanation for dawn phenomenon in patients with type 2 diabetes

New covalent and non-covalent SARS-CoV-2 inhibitors discovered in silico

Scientists use ultrasound to map arrhythmic sites more accurately

Speakers Announced for Virtual Experimental Biology 2021 Meeting

YAP inhibitors could facilitate targeted treatment of basal-like breast cancer

SARS-CoV-2 spike stimulates hyperinflammation via Toll-like receptor 2

INTEGRA’s electronic pipettes enable reproducible analysis in microbial evolution research

Amino acids signaling controls whole-body glucose homeostasis, study shows

UAB researchers find potential new pathway to treating radiation-resistant glioblastoma

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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