Medicinal Chemistry News and Research

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New compounds from fungi show promise in treating colorectal cancer

Novel chemical compounds from a fungus could provide new perspectives for treating colorectal cancer, one of the most common and deadliest cancers worldwide.

17 Oct 2024

Breakthrough in mirror molecule synthesis opens doors for drug discovery

A University of Texas at Dallas chemist and his colleagues have developed a new chemical reaction that will allow researchers to synthesize selectively the left-handed or right-handed versions of "mirror molecules" found in nature and assess them for potential use against cancer, infection, depression, inflammation and a host of other conditions.

10 Oct 2024

Understanding proteasome function in Trichomonas vaginalis for drug development

Researchers from IOCB Prague are furthering the understanding of how medicines work and what it takes to develop their most effective variants.

8 Oct 2024

Novel semi-synthetic compound shows promise against drug-resistant tuberculosis

A new study published in the American Society for Microbiology journal Microbiology Spectrum demonstrates that a novel semi-synthetic compound can be derived from natural compounds to produce potent activity against Mycobacterium tuberculosis, including multi-drug resistant strains.

3 Oct 2024

Evolution of vaccine adjuvants from empirical discovery to rational design

Vaccine adjuvants have evolved significantly since their inception, transitioning from empirical discovery to a more structured approach grounded in rational drug design.

13 Sep 2024

Self-assembling heart stimulator can correct heart arrhythmia in emergency situations

By injecting a solution of nanoparticles around the heart, a temporary heart stimulator self-assembles, which can correct heart arrhythmia in emergency situations with the help of an external power source.

27 Aug 2024

Breakthrough compound targets appetite and tau protein in obesity and Alzheimer's

Scientists on the team of Dr Lenka Maletínská have developed a promising new compound derived from one of the peptides naturally occurring in the brain.

21 Aug 2024

Marine snail venom may inspire new diabetes and hormone disorder treatments

Scientists are finding clues for how to treat diabetes and hormone disorders in an unexpected place: a toxin from one of the most venomous animals on the planet.

20 Aug 2024

SwRI develops a unique technology to screen new DNA-targeting therapeutics

Southwest Research Institute (SwRI) has developed a unique technology to screen new DNA-targeting therapeutics designed to treat cancer and other diseases.

19 Aug 2024

New dual-purpose contrast agent revolutionizes PET and MRI integration for enhanced diagnosis

A research team from IOCB Prague, working in collaboration with the University of Tübingen, Germany, and the Faculty of Science, Charles University, has developed a new type of contrast agent that can be used in both magnetic resonance imaging (MRI) and positron emission tomography (PET).

5 Aug 2024

Xanthones show promise in diabetes with antioxidant and anti-inflammatory properties

Research reveals xanthones as promising agents in diabetes management, offering antioxidant, anti-inflammatory, and insulin-sensitizing benefits.

29 Jul 2024

Research reveals immune suppression link between cancer and pregnancy

To understand why some cancers successfully circumvent the immune system to grow unchecked, researchers turned to pregnancy.

8 Jul 2024

Small molecule discovery offers hope for treatment of Angelman syndrome

Angelman syndrome is a rare genetic disorder caused by mutations in the maternally-inherited UBE3A gene and characterized by poor muscle control, limited speech, epilepsy, and intellectual disabilities.

8 Jul 2024

Exploring PRM-A as a novel glycan-targeted therapy for SARS-CoV-2 inhibition

HIV, Ebola and most recently, COVID-19 viruses have had an enormous impact on our societies world-wide.

4 Jul 2024

Novel compound amplifies naloxone's power to reverse overdoses

In a Stanford Medicine-led study, researchers combed through billions of compounds to find one that could enhance naloxone’s ability to fend off more potent opioids, with promising results in mice.

4 Jul 2024

Visible light technique simplifies synthesis of key pharmaceutical building blocks

University of Michigan chemists have discovered a way to use visible light to synthesize a class of compounds particularly well suited for use in pharmaceuticals.

2 Jul 2024

Moffitt scientists develop breakthrough method for scalable synthesis of withanolides

Withanolides, a class of naturally occurring compounds found in plants, have long been a focus of cancer research due to their ability to inhibit cancer cell growth, induce cell death and prevent metastasis.

28 Jun 2024

New drug-like molecules show promise in preventing influenza by blocking virus entry

Currently available flu medications only target the virus after it has already established an infection, but what if a drug could prevent infection in the first place?

21 May 2024

Reviving a rejected drug: New selective antibiotic shows promise

Twenty years ago, a drug candidate was rejected due to its side effects. Researchers have now figured out how to potentially make a successor molecule more selective.

17 May 2024

Researchers develop pathoblockers to combat bacterial pneumonia toxins

In most cases, antibiotics are a reliable form of protection against bacterial infections. They have saved billions of human lives since their introduction.

16 May 2024