Phosphorylation News and Research

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The molecular context and substrate profiles of human cell surface receptor tyrosine kinases

researchers discussed and identified the systemic functions and interactions of 52 active cell surface receptor tyrosine kinases, providing insights on RTK-RTK interactions and substrates, RTK-protein complexes, and signaling pathways.

13 Apr 2022

Scientists find critical role for Hippo signaling pathway in COVID-19 pathogenesis

A recent article posted to the bioRxiv* preprint server illustrated that the activation of the Hippo signaling pathway upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection aids the host antiviral response.

11 Apr 2022

Exploring evolutionary trajectories of SARS-CoV-2 interacting proteins in bats and primates

Researchers performed high-throughput evolutionary analyses of genes encoding 334 SARS-CoV-2 viral-interacting proteins of modern humans, primates, and bats.

11 Apr 2022

Examining hypomagnesemia in critically ill patients with Acute Kidney Injury (AKI)

In this interview, News-Medical talks to Dr. Francesca Di Mario, about hypomagnesemia in critically ill patients suffering from acute kidney injuries and discusses how Nova Biomedical instruments are utilized in her work.

From Nova Biomedical 6 Apr 2022

Developing and manufacturing custom recombinant antibodies for R&D

In this interview, Dr. Linlin Zhang, technical specialist for Sino Biological Europe, discusses how Sino is expanding its product offerings into the European market and outlines its process for developing and manufacturing custom recombinant antibodies for their clients.

From Sino Biological Inc. 6 Apr 2022

Decisive role of PDK1 enzyme in acute myeloid leukemia revealed

Acute myeloid leukemia (AML) remains harder to treat therapeutically due to the high existing genetic heterogeneity not only between patients but also between the population of subclones of cancer cells within the same person.

30 Mar 2022

Antiviral functions of interferon regulatory factors during human coronavirus infection

Researchers assessed the roles of the interferon regulatory factors: IRF1, IRF3, and IRF7 in infections by human coronaviruses.

30 Mar 2022

Study shows that the SARS-CoV-2 envelope protein potently restricts HIV-1 infection

Researchers demonstrated that E proteins of β-coronaviruses could restrict HIV-1 infection.

30 Mar 2022

SARS-CoV-2 nucleocapsid protein linked to COVID-19 severity

The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes respiratory coronavirus disease 2019 (COVID-19) triggered an unprecedented public health emergency. Human mobility patterns were fundamental to the spread of SARS-CoV-2 globally. The situation is particularly acute in a country like Saudi Arabia, which has seen more than 750,000 cases and over 9,000 deaths as of March 30th, 2022.

29 Mar 2022

Furin inhibitors as potential therapies to combat SARS-CoV-2 and other diseases

Furin inhibitors as potential therapeutics for treating COVID-19 and other diseases, wherein furin is integral for their pathogenicity and progression.

29 Mar 2022

Trial shows effectiveness of new classes of dual active ingredient insecticidal nets against malaria

IVCC welcomes the publication in The Lancet of the 24-month results of an epidemiological trial in Tanzania, conducted by the London School of Hygiene and Tropical Medicine in partnership with the National Institute for Medical Research, Kilimanjaro Christian Medical University College, and the University of Ottawa, to assess the public health value of two dual active ingredient nets compared to standard LLINs containing pyrethroids only.

29 Mar 2022

Importance of Numb-associated kinases in SARS-CoV-2 infection

A new study posted to the bioRxiv* preprint server has focussed on assessing four members of the NAK family that are associated with SARS-CoV-2 infection. These kininases could act as a target for the development of effective COVID-19 therapeutics.

23 Mar 2022

Study reveals novel tumor biomarker of aggressive cancers with poor prognosis

A study published in The Journal of Pathology reveals that many cancers that carry a poor prognosis express an altered form of human telomerase reverse transcriptase (hTERT), an enzyme that regulates the expression of multiple genes.

22 Mar 2022

Study reveals how to identify and avoid risks related to mitochondrial therapeutic interventions

Research carried out at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has demonstrated that mixing mitochondrial DNAs (mtDNAs) of different origins can have damaging effects over the medium and long term.

16 Mar 2022

Bioactive small molecules enhance CRISPR/Cas9 loss-of-function editing in human cells

Researchers demonstrate enhanced loss-of-function editing of CRISPR/Cas9 in human cells.

14 Mar 2022

Pain neuron-derived peptide protects mice from endotoxic death by enhancing brain ATP production

Sepsis is a high-mortality disease that arises when the body's immune reaction to pathogens causes multi-organ defects.

9 Mar 2022

Effect of COVID-19 mRNA vaccine on in vitro glial cells of the brain studied by Raman spectroscopy and imaging

Researchers studied how the mRNA-based BNT162b2 COVID-19 vaccine altered the biochemical composition of glial and glioma brain cells in vitro.

8 Mar 2022

Disruption of sleep and circadian rhythm can increase the chances of contracting a virus

A recent study explores the effect of sleep and circadian rhythm dispersion on mouse lung transcriptome after six of hours sleep deprivation.

6 Mar 2022

Melatonin as a safe and potentially life-saving treatment for COVID-19

A new study discusses the possible role of melatonin, an antioxidant and anti-inflammatory agent, in treating COVID-19.

24 Feb 2022

Study reveals sex-dimorphic immune imprints and in vivo functional impacts of mild COVID-19

Researchers used a systems immunology approach to analyze the immune states of healthy and non-obese subjects who recovered from mild COVID-19 and compared them with age- and sex-matched COVID-19-naive controls.

24 Feb 2022

Phosphorylation News and Research

The molecular context and substrate profiles of human cell surface receptor tyrosine kinases

Scientists find critical role for Hippo signaling pathway in COVID-19 pathogenesis

Exploring evolutionary trajectories of SARS-CoV-2 interacting proteins in bats and primates

Examining hypomagnesemia in critically ill patients with Acute Kidney Injury (AKI)

Developing and manufacturing custom recombinant antibodies for R&D

Decisive role of PDK1 enzyme in acute myeloid leukemia revealed

Antiviral functions of interferon regulatory factors during human coronavirus infection

Study shows that the SARS-CoV-2 envelope protein potently restricts HIV-1 infection

SARS-CoV-2 nucleocapsid protein linked to COVID-19 severity

Furin inhibitors as potential therapies to combat SARS-CoV-2 and other diseases

Trial shows effectiveness of new classes of dual active ingredient insecticidal nets against malaria

Importance of Numb-associated kinases in SARS-CoV-2 infection

Study reveals novel tumor biomarker of aggressive cancers with poor prognosis

Study reveals how to identify and avoid risks related to mitochondrial therapeutic interventions

Bioactive small molecules enhance CRISPR/Cas9 loss-of-function editing in human cells

Pain neuron-derived peptide protects mice from endotoxic death by enhancing brain ATP production

Effect of COVID-19 mRNA vaccine on in vitro glial cells of the brain studied by Raman spectroscopy and imaging

Disruption of sleep and circadian rhythm can increase the chances of contracting a virus

Melatonin as a safe and potentially life-saving treatment for COVID-19

Study reveals sex-dimorphic immune imprints and in vivo functional impacts of mild COVID-19

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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