Proliferation News and Research

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The relationship between breast milk feeding and infants’ neurodevelopment via epigenetics

Researchers collated studies on the epigenetic advantages of breast milk feeding and neurodevelopment in infants.

22 Aug 2023

Less is more: Radiotherapy omission deemed safe for certain breast cancer patients

The risk of breast cancer recurrence after breast-conserving surgery.

22 Aug 2023

Are irregular sleep patterns associated with increased mortality risk?

Researchers examined whether sleep regularity is associated with an increased risk of all-cause, cardiovascular disease (CVD), and cancer mortality.

22 Aug 2023

Platelets play a role in mediating the rejuvenating effects of exercise during physiological brain ageing

The impacts of physical activity on the neuronal formation and prevent age-related cognitive decay.

22 Aug 2023

Anti-estrogenic therapies can suppress growth of ER-negative cancers

Anti-estrogenic therapies can suppress the growth of cancer that does not express estrogen receptors; when combined with immune checkpoint inhibitor therapies, they halt tumor progression in mice models.

21 Aug 2023

Alcohol-associated bowel disease: A review of the literature

Alcohol consumption is a significant risk factor for gastrointestinal diseases, including cancer. Alcohol can damage the gastrointestinal tract in several ways.

21 Aug 2023

How effective is the keto diet for managing PCOS?

Scientists discuss the metabolic advantages of the ketogenic diet in the management of polycystic ovarian syndrome.

21 Aug 2023

Regulation of cytotoxic T-cell differentiation and exhaustion by mTOR signaling

Researchers describe molecular signalling regulated by mTOR among memory and exhausted cytotoxic CD8+ T lymphocytes.

18 Aug 2023

New small molecule drug targets active state of cancer-causing KRAS mutant

A new small molecule drug helps to bind the naturally occurring cellular chaperone cyclophilin A (CYPA) to the active state of the cancer-causing mutant KRASG12C, disrupting oncogenic signaling and tumor growth in several models of human cancer.

17 Aug 2023

Androgen deprivation therapy increases the risk of depression, dementia, Alzheimer’s disease, and Parkinson’s disease

The association between Androgen Deprivation Therapy (ADT) and the risk of dementia.

16 Aug 2023

Unveiling hidden threats: clustering loops in CAR-T cells impact cancer therapy

How complementarity-determining region (CDR) loops in the single-chain variable fragment (scFv) influence chimeric antigen receptor (CAR)-T cell behavior.

14 Aug 2023

Scientists develop synthetic extracellular matrix to support growth of mini endometrium in a dish

Scientists have developed a synthetic extracellular matrix (ECM) that can support the growth of a mini endometrium in a dish for at least two weeks.

11 Aug 2023

New gene therapy shows promise for treating fusion-driven cancers

A new study presents a promising treatment method for so-called fusion-driven cancers, which are currently often difficult to cure. These fusion-driven cancers are caused by an error in cell division that creates a fusion of different genes.

11 Aug 2023

Study explores the use of existing medicines to revolutionize cancer treatment

In a recent study published in the journal of Genes & Diseases, Research team led by Lu explores the potential for the use of FDA-approved hypertension and EMA-approved cough medicines to revolutionize cancer treatment.

10 Aug 2023

The impact of epigenetic features on breast cancer treatment and outcomes

The impact of epigenetic features on breast cancer treatment and outcomes.

9 Aug 2023

The immune-modulatory effect of lenvatinib investigated in new study

Researchers explore the effect of lenvatinib treatment on patients with advanced thyroid cancer.

9 Aug 2023

RAGE plays key role in cellular mechanisms of plasticity in aggressive triple-negative breast cancer

Published online ahead of print in the journal Oncogene , a study led by Josep Villanueva, an Investigator at the Vall d'Hebron Institute of Oncology (VHIO), shows that the receptor for advanced glycation end-product (RAGE) plays a key role in cellular mechanisms of plasticity in mesenchymal triple-negative breast cancer (TNBC) that transform epithelial cells into mesenchymal cells as potent drivers of cancer cell proliferation and tumor invasion.

8 Aug 2023

NCI funds study to investigate the underlying cellular mechanisms that drive ER+ breast cancer

The National Cancer Institute (NCI) has awarded a 5-year, $2.7 million grant to researchers at Sanford Burnham Prebys to investigate and elucidate the underlying cellular mechanisms that drive the most common form of breast cancer.

7 Aug 2023

Researchers uncover genetic machinery responsible for EBV-induced B cell growth transformation

B cells or B lymphocytes are an important part of the body's immune system. When healthy B cells are infected with the Epstein-Barr virus (EBV), they undergo growth transformation, a process that immortalizes B cells, leading to their uncontrolled proliferation.

7 Aug 2023

Understanding variations in SARS-CoV-2 evolution and clearance by immunodeficiency status

Researchers describe the virological range of persistent SARS-CoV-2 infection in immunosuppressed individuals.

7 Aug 2023

Proliferation News and Research

The relationship between breast milk feeding and infants’ neurodevelopment via epigenetics

Less is more: Radiotherapy omission deemed safe for certain breast cancer patients

Are irregular sleep patterns associated with increased mortality risk?

Platelets play a role in mediating the rejuvenating effects of exercise during physiological brain ageing

Anti-estrogenic therapies can suppress growth of ER-negative cancers

Alcohol-associated bowel disease: A review of the literature

How effective is the keto diet for managing PCOS?

Regulation of cytotoxic T-cell differentiation and exhaustion by mTOR signaling

New small molecule drug targets active state of cancer-causing KRAS mutant

Androgen deprivation therapy increases the risk of depression, dementia, Alzheimer’s disease, and Parkinson’s disease

Unveiling hidden threats: clustering loops in CAR-T cells impact cancer therapy

Scientists develop synthetic extracellular matrix to support growth of mini endometrium in a dish

New gene therapy shows promise for treating fusion-driven cancers

Study explores the use of existing medicines to revolutionize cancer treatment

The impact of epigenetic features on breast cancer treatment and outcomes

The immune-modulatory effect of lenvatinib investigated in new study

RAGE plays key role in cellular mechanisms of plasticity in aggressive triple-negative breast cancer

NCI funds study to investigate the underlying cellular mechanisms that drive ER+ breast cancer

Researchers uncover genetic machinery responsible for EBV-induced B cell growth transformation

Understanding variations in SARS-CoV-2 evolution and clearance by immunodeficiency status

Innovations in baculovirus–insect cell expression systems

Compound Management and its Crucial Role in Early Pharmaceutical Research

Natural products: the next frontier in drug discovery

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