Small Molecules News and Research

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Damon Runyon Cancer Research Foundation announces newest cohort of Fellows and Breakthrough Scientists

The Damon Runyon Cancer Research Foundation has announced its newest cohort of Damon Runyon Fellows, 13 outstanding postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators.

29 Jan 2022

SARS-CoV-2 virus co-opts intrinsic cellular machinery to suppress interferon production

In a recent study posted to the bioRxiv* preprint server, researchers evaluated the mechanism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated inflammatory marker interferon (IFN) repression in hosts.

25 Jan 2022

Link established between gut microbiota and chronic inflammatory diseases

An international research team has established a link between gut microbiota and chronic inflammatory diseases such as arthritis.

25 Jan 2022

New COVID-19 vaccine promises vaccine equity because it has no patents

Corbevax, a new vaccine against COVID-19, may have better success as a candidate for vaccine equity because it carries no patents, relies on long-established recombinant technology for manufacture and has the support of the US and Indian governments, its makers and health experts say.

21 Jan 2022

Exploring biological characteristics of SARS-CoV-2-induced myocardial damage

In a new study, researchers used bioinformatics tools to explore the biological characteristics of SARS-CoV-2-infected myocardium.

19 Jan 2022

Study finds SARS-CoV-2 infection caused significant changes in the levels of stress associated small RNAs

In this study, researchers described the effect of significant changes of small RNAs in the post-transcriptional regulatory network.

13 Jan 2022

AI-driven solution predicts RNA and DNA binding sites to accelerate rational drug discovery

The iMolecule group from Skoltech has developed an artificial intelligence-driven solution that uses data on the structure of RNA or DNA molecules to identify sites on them where interaction with potential drug candidates can occur.

11 Jan 2022

NYBC discovers novel small-molecule pancoronavirus fusion inhibitors

New York Blood Center has published a study that reports the discovery of highly potent small molecules with the ability to inhibit COVID-19 in infected individuals.

9 Jan 2022

From laboratory to clinic - Nanotechnology-enabled mRNA COVID-19 vaccines

In a recently published article in the journal Nano-Micro Letters, scientists have provided an in-depth review on the application and benefits of nanotechnology in the development of coronavirus disease 2019 (COVID-19) vaccines.

7 Jan 2022

Small molecule identified as a SARS-CoV-2 inhibitor

A new study published in iScience reports the results of a screening strategy to identify small molecules that target viral entry to block infection with this virus.

6 Jan 2022

An integrated computational methodology for COVID drug prioritization

Researchers recently published a study in the journal Briefings in Bioinformatics wherein they integrated multiple bioinformatics and cheminformatics-based methods to prioritize drugs for the treatment of COVID-19.

29 Dec 2021

Boceprevir-based molecules show high antiviral potency against SARS-CoV-2

In a study posted to the bioRxiv* pre-print server, a team of researchers conducted a structure-activity relationship study of boceprevir-based molecules to find antiviral drug candidates targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protease MPro.

22 Dec 2021

Study suggests nitazoxanide fails to reduce the severity of SARS-CoV-2

A new study shows that the optimization of nitazoxanide formulations may allow the review of the potential use of the drug for the treatment of SARS-CoV-2 infection.

22 Dec 2021

Molecular mechanism of SARS-Cov-2-induced thrombosis

Researchers demonstrate that the exposure of platelets to the SARS-CoV-2 spike protein promotes their activation and adhesion.

21 Dec 2021

Natural triterpenoids in licorice found to inhibit SARS-CoV-2

In new studies, researchers concluded that licorice triterpenoids could be candidates for anti-SARS-CoV-2 drug developments.

2 Dec 2021

Complex RNA structures could have untapped therapeutic potential in the fight against COVID-19

To the untrained eye, the loops, kinks and folds in the single strand of RNA that makes up the coronavirus genome look like a jumble of spaghetti or tangled yarn. But to researchers like Amanda Hargrove, a chemistry professor at Duke University, the complex shapes that RNA takes on as it folds upon itself could have untapped therapeutic potential in the fight against COVID-19.

26 Nov 2021

Small Molecules News and Research

Damon Runyon Cancer Research Foundation announces newest cohort of Fellows and Breakthrough Scientists

SARS-CoV-2 virus co-opts intrinsic cellular machinery to suppress interferon production

Link established between gut microbiota and chronic inflammatory diseases

New COVID-19 vaccine promises vaccine equity because it has no patents

Exploring biological characteristics of SARS-CoV-2-induced myocardial damage

Study finds SARS-CoV-2 infection caused significant changes in the levels of stress associated small RNAs

AI-driven solution predicts RNA and DNA binding sites to accelerate rational drug discovery

NYBC discovers novel small-molecule pancoronavirus fusion inhibitors

From laboratory to clinic - Nanotechnology-enabled mRNA COVID-19 vaccines

Small molecule identified as a SARS-CoV-2 inhibitor

An integrated computational methodology for COVID drug prioritization

Boceprevir-based molecules show high antiviral potency against SARS-CoV-2

Study suggests nitazoxanide fails to reduce the severity of SARS-CoV-2

Molecular mechanism of SARS-Cov-2-induced thrombosis

Natural triterpenoids in licorice found to inhibit SARS-CoV-2

Complex RNA structures could have untapped therapeutic potential in the fight against COVID-19

Oral Hsp90 inhibitor SNX-5422 interferes with replication machinery of SARS-CoV-2

Novel technique solves structure of the HIV capsid alone and in complex with host factors

Researchers identify compounds that tackle fungal infections in a new way

Scientists use advanced microscopes to delve deeper into protein degradation process

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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