Smallpox News and Research

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Smallpox is a highly contagious disease caused by the variola virus, a member of the Orthopox virus family. It is one of the most devastating diseases known to humanity, with a mortality rate as high as 30%. In 1967, the World Health Organization embarked upon an intensified vaccination campaign to eliminate smallpox, which culminated in the successful eradication of the disease globally by 1980.

By the mid-1980s, there were only two known repositories of variola virus: the Institute of Virus Preparations in Russia, and the US CDC. The events in the US in September and October 2001 highlighted the risk that the variola virus might be used as an agent of bioterrorism. Governments around the world are taking precautionary measures to be ready to deal with a potential smallpox outbreak.
Small UK study investigates the effectiveness of a single MVA-BN dose against mpox disease

Small UK study investigates the effectiveness of a single MVA-BN dose against mpox disease

Modeling study offers a road map for public health to maximize the impact of monkeypox vaccines

Modeling study offers a road map for public health to maximize the impact of monkeypox vaccines

Novel mRNA vaccines encoding Monkeypox virus proteins show promise in preclinical studies

Novel mRNA vaccines encoding Monkeypox virus proteins show promise in preclinical studies

Study concludes monkeypox virus is readily detected by qPCR using three clinically validated assays

Study concludes monkeypox virus is readily detected by qPCR using three clinically validated assays

Black, Hispanic MSM disproportionately affected by monkeypox

Black, Hispanic MSM disproportionately affected by monkeypox

Can monkeypox infection lead to myocarditis?

Can monkeypox infection lead to myocarditis?

Immunological responses against monkeypox virus concerning the 2022 outbreak

Immunological responses against monkeypox virus concerning the 2022 outbreak

What are the eye complications associated with monkeypox infection?

What are the eye complications associated with monkeypox infection?

Phylodynamic analysis of the monkeypox virus genome suggests low genetic variation and evolutionary rates

Phylodynamic analysis of the monkeypox virus genome suggests low genetic variation and evolutionary rates

Specific mutations in the monkeypox virus contribute to its continued infectiousness

Specific mutations in the monkeypox virus contribute to its continued infectiousness

How does the ISG15/ISGylation system modulate Vaccinia virus infection?

How does the ISG15/ISGylation system modulate Vaccinia virus infection?

'What pediatricians need to know' about monkeypox in children

'What pediatricians need to know' about monkeypox in children

UC San Diego participates in national trial to assess potential treatment for human monkeypox

UC San Diego participates in national trial to assess potential treatment for human monkeypox

Researchers use models developed for COVID-19 predictions to predict and simulate monkeypox transmission and vaccination scenarios

Researchers use models developed for COVID-19 predictions to predict and simulate monkeypox transmission and vaccination scenarios

Monkeypox virus infection and its persistence in the testes of infected crab-eating macaques

Monkeypox virus infection and its persistence in the testes of infected crab-eating macaques

Review of characteristics of human monkeypox

Review of characteristics of human monkeypox

UK hospital study explores whether monkeypox can be transmitted through aerosolized droplets and fomites

UK hospital study explores whether monkeypox can be transmitted through aerosolized droplets and fomites

Mass General Brigham sites announce participation in phase 3 trial of monkeypox treatment

Mass General Brigham sites announce participation in phase 3 trial of monkeypox treatment

Bioinformatics analysis of monkeypox virus-host cell interactions

Bioinformatics analysis of monkeypox virus-host cell interactions

Scientists detect monkeypox virus in the testes of macaques during acute infection

Scientists detect monkeypox virus in the testes of macaques during acute infection

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