Therapeutics News and Research

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Researchers identify drug with anti-aging effects

Aging is an inevitable phenomenon and is accompanied by several comorbidities. To this end, research into the effects of aging has become paramount, and scientists are looking for ways to slow down aging and its detrimental impact on the human body.

25 Sep 2024

CRISPR-Cas13 emerges as a game changer in RNA-targeted therapies

In recent years, the scientific community has made significant strides in the field of gene editing, particularly through the development of the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) systems.

25 Sep 2024

Innovative HiTIP-seq method advances epigenetic research in pediatric brain tumors

Diffuse midline glioma (DMG) is a highly aggressive and fatal pediatric high-grade glioma that primarily affects critical regions of the central nervous system, such as the pons, thalamus, and spinal cord.

24 Sep 2024

Neurostimulation target identified for treating PTSD in veterans

A new study led by researchers at Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, suggests that using neurostimulation therapies on a specific brain network could treat post traumatic stress disorder (PTSD) in veterans.

24 Sep 2024

Space conditions disrupt rhythmic function of bioengineered heart tissues

Johns Hopkins Medicine scientists who arranged for 48 human bioengineered heart tissue samples to spend 30 days at the International Space Station report evidence that the low gravity conditions in space weakened the tissues and disrupted their normal rhythmic beats when compared to earth-bound samples from the same source.

23 Sep 2024

Breakthrough research reveals key role of melatonin receptor in REM sleep

A significant breakthrough in the understanding of sleep mechanism opens new promise for treating sleep disorders and associated neuropsychiatric conditions: Scientists have pinpointed the melatonin receptor MT1 as a crucial regulator of REM (Rapid Eye Movement) sleep.

23 Sep 2024

Urgent call for long-term investment in antibiotic research

Antibiotic resistance is a global public health threat. Modern health systems rely on antibiotics to prevent and treat infections, and the need for new drugs is urgent.

23 Sep 2024

Study uncovers novel genetic variant associated with intellectual disability

Researchers at the Icahn School of Medicine at Mount Sinai have published a pivotal study in Nature Genetics (DOI: 10.1038/s41588-024-01917-1) that sheds light on a novel genetic variant associated with intellectual capacities and educational outcomes.

23 Sep 2024

Broken String Biosciences appoints Laurence Reid and Brad Crutchfield to its Board of Directors

Broken String Biosciences enhances its leadership team with Laurence Reid and Brad Crutchfield, aiming to revolutionize cell and gene therapy development.

From Broken String Biosciences 23 Sep 2024

Liraglutide activates key brain circuits to trigger weight loss in obesity

Researchers uncover how liraglutide targets specific brain regions to suppress appetite and promote significant weight loss through GLP-1 receptor activation.

23 Sep 2024

MaxCyte signs strategic platform license with Kamau Therapeutics to accelerate the development of cell therapies for genetic diseases

MaxCyte, Inc., a leading, cell-engineering focused company providing enabling platform technologies to advance the discovery, development and commercialization of next-generation cell-based therapeutics and innovative bioprocessing applications, and Kamau Therapeutics, a clinical-stage stem cell therapy gene correction company, today announced they are entering into a strategic platform license (SPL) agreement.

From MaxCyte, Inc. 23 Sep 2024

New insights into lasso peptides offer promise for drug development

Lasso peptides are natural products made by bacteria. Their unusual lasso shape endows them with remarkable stability, protecting them from extreme conditions

20 Sep 2024

STING protein plays new role in cellular stress clearance and survival

A protein called STING, previously shown to control a pathway that contributes to antiviral signaling, also plays an important role in cellular stress clearance and cell survival, according to a new paper published in Molecular Cell.

20 Sep 2024

Novel drug molecule offers hope for early Parkinson's disease treatment

A novel drug molecule could potentially lead to new treatments to prevent Parkinson's disease in younger patients, according to new research.

20 Sep 2024

New research strengthens the case for a zoonotic origin of COVID-19

A new international collaborative study provides a list of the wildlife species present at the market from which SARS-CoV-2, the virus responsible for the COVID-19 pandemic, most likely arose in late 2019. The study is based on a new analysis of metatranscriptomic data released by the Chinese Center for Disease Control and Prevention (CDC).

20 Sep 2024

Researchers identify bacterial strains to combat antibiotic-resistant gut infections

Antibiotic-resistant bacterial infections often occur in patients with chronic inflammatory intestinal conditions, such as inflammatory bowel disease, and in patients who have taken antibiotics for a long time.

19 Sep 2024

Global fight against antimicrobial resistance sees surge in deaths among older adults

Comprehensive study estimates the global antimicrobial resistance (AMR) burden from 1990 to 2021, identifying significant age and regional disparities. It highlights future AMR death projections and underscores the importance of prevention and new antibiotic development.

19 Sep 2024

Study highlights disparities in stroke burden across regions

Although stroke is highly preventable and treatable, there has been a rapid rise in the global stroke burden between 1990 and 2021, due to both population growth and the rise of aging populations worldwide, as well as a substantial increase in people's exposure to environmental and behavioral risk factors.

19 Sep 2024

New biomarkers offer hope for early detection and prevention of Alzheimer's

The failure to diagnose Alzheimer's disease, the most common form of dementia in the elderly, at an early stage of molecular pathology is considered a major reason why treatments fail in clinical trials. Previous research to molecularly diagnose Alzheimer's disease yielded "A/T/N" central biomarkers based on the measurements of proteins, β-amyloid ("A") and tau ("T"), and "N" encompassing neurodegeneration. A/T/N can be measured in brain tissue, by in vivo brain imaging techniques, and by analysis of cerebrospinal fluid and plasma.

18 Sep 2024

Asimov launches AAV Edge, a suite of AI models, host cells, and genetic tools for end-to-end gene therapy development

Asimov, the synthetic biology company advancing the design and production of therapeutics, today announced the launch of the AAV Edge System, a comprehensive suite of tools for adeno-associated viral (AAV) gene therapy design and manufacturing.

18 Sep 2024