immunity News and Research

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Naive B cells could be useful for predicting vaccination response in immunocompromised

A recent study conducted at the Medical University of Graz, Austria, has revealed that the number of naïve B cells in the blood could independently predict the magnitude of immune response induced by coronavirus disease 2019 (COVID-19) vaccines in immunocompromised patients. The study is currently available on the medRxiv* preprint server.

17 Aug 2021

Delta variant unable to evade antibodies elicited by COVID-19 vaccination, finds study

Despite causing a surge in infections this summer that has resulted in thousands of hospitalizations and deaths, the delta variant of the virus that causes COVID-19 is not particularly good at evading the antibodies generated by vaccination, according to a study by researchers at Washington University School of Medicine in St. Louis.

17 Aug 2021

Study explores the role of nasal bacteria and provides clues to developing better flu, COVID-19 vaccines

While gut microbiota play a critical role in the induction of adaptive immune responses to influenza virus infection, the role of nasal bacteria in the induction of virus-specific adaptive immunity is less clear.

17 Aug 2021

New rapid test for understanding immunity against COVID-19

Electronics specialist Mantracourt has helped engineer a new rapid test which will tell people whether they have immunity against coronavirus and whether that immunity comes from developing antibodies after infection or the vaccine.

17 Aug 2021

In Southeast Asia, robust immunity found up to 9 months after SARS-CoV-2 infection

Now, a new study posted to the bioRxiv* preprint server focuses on functional immune memory to SARS-CoV-2, up to nine months in a Southeast Asian cohort, in the absence of re-infection.

16 Aug 2021

Vaccinating previously infected induces more potent antibodies less susceptible to escape from SARS-CoV-2 variants

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causal agent of the coronavirus disease 2019 (COVID-19) pandemic, which has claimed more than 4.3 million lives worldwide. Even after implementing various measures, such as vaccination and social restrictions, SARS-CoV-2 and its variants of concern (VoC) leave the world's public health systems and economies in turmoil.

16 Aug 2021

Tool for defining new SARS-CoV-2 spike nucleotide sequences to Pango lineage sets

In a recent study, a group of researchers determined the degree to which Pango lineages are distinguishable using spike-only nucleotide sequences.

16 Aug 2021

Small protein prevents immune system from destroying pancreatic cells in type 1 diabetes-prone mice

A new study has shown that treating type 1 diabetes-prone mice with the small protein MOTS-c prevented the immune system from destroying insulin-producing pancreatic cells, effectively preventing the onset of the autoimmune disease.

16 Aug 2021

Penn researchers reveal complex details of T-cell responses to mRNA COVID-19 vaccines

Messenger-RNA (mRNA) vaccines against the coronavirus that causes COVID-19 provoke a swift and strong response by the immune system's T cells-;the heavy armor of the immune system-;according to a study from researchers in the Perelman School of Medicine at the University of Pennsylvania.

16 Aug 2021

Obtained SARS-CoV-2 immunity, naturally or via vaccination persists 12 months

In a research paper recently uploaded to the preprint server medRxiv* by Havervall et al. (August 12th, 2021), neutralizing antibody titers towards wild-type SARS-CoV-2 and several variants of concern in individuals having either been vaccinated or infected with mild COVID-19 one year earlier are assessed, finding a reduced neutralization capacity against some strains.

16 Aug 2021

Response to a third SARS-CoV-2 vaccine dose amongst immunocompromised

In a research paper recently uploaded to the preprint server medRxiv* by Schrezenmeier et al. (August 12th, 2021) the potential benefit of three vaccine doses in either a homogenous or heterogeneous dosing regimen amongst kidney transplant patients is assessed, finding that the search for viable vaccination approaches amongst these patients remains an urgent medical need.

16 Aug 2021

Researchers assess the genetic features of T-cell immunity development to SARS-CoV-2 variants

The continuing emergence of new SARS-CoV-2 mutations allows the virus to spread more effectively and evade antibodies. However, it is unclear whether new strains are capable of evading T-cell immunity-; one of the body's main lines of defense against COVID-19.

16 Aug 2021

Primate study shows benefit of mRNA vaccine booster shot against SARS-CoV-2 variants

In a recent bioRxiv* preprint research paper, a large group of US scientists demonstrate how a booster dose of the mRNA-1273 vaccine can substantially improve both the potency and range of neutralizing antibody responses and mediate protection against upper and lower airway infection by a range of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern – even those relatively resistant to in vitro neutralization.

16 Aug 2021

First dose of COVID-19 vaccine to be offered to all young people aged 16 to 17 in England

All young people aged 16 to 17 in England are to be offered the first dose of a COVID-19 vaccine by Monday 23 August to give them the vital protection provided by the vaccine before returning to school in September, the Health and Social Secretary Sajid Javid has announced today (15 August).

16 Aug 2021

Modeling the spread and development of SARS-CoV-2 outbreaks in the US

In a research paper recently uploaded to the medRxiv* preprint server, high-resolution contact data is utilized to characterize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in the USA, considering infections' mobility and seasonality and vaccination status seroprevalence within the population.

15 Aug 2021

Role of neutrophil-epithelial interactions in SARS-CoV-2 infection

Researchers discuss the relationship between airway neutrophils and SARS-CoV-2 infection to determine the impact that neutrophils have on COVID-19.

15 Aug 2021

Utah warns of Delta variant eroding COVID vaccine effectiveness

A recent study finds a reduction in vaccine effectiveness against COVID-19 in Utah corresponding to the spread of the Delta variant in the region.

15 Aug 2021

Certain intestinal bacteria induce cross-reactive IgA responses to the SARS-CoV-2 spike RBD

A new study finds that human gut bacteria can induce antibodies of the immunoglobulin A (IgA) subtype that cross-react with the SARS-CoV-2 spike RBD.

15 Aug 2021

World-first trial of third dose COVID-19 booster vaccine shows improved protection in transplant patients

Scientists with the Ajmera Transplant Centre at UHN have conducted a first-in-the-world randomized placebo-controlled trial of third dose COVID-19 booster vaccine for transplant patients that shows substantially improved protection.

14 Aug 2021

Enzyme acts as a sensor to find the hiding spots of viruses

While some types of RNA viruses cloak themselves to hide inside a cell and create copies of themselves, a "detective enzyme" might be attuned to their whereabouts. A slight variation in their genomic code gives some people's cells the capacity to produce this sensor.

14 Aug 2021

immunity News and Research

Naive B cells could be useful for predicting vaccination response in immunocompromised

Delta variant unable to evade antibodies elicited by COVID-19 vaccination, finds study

Study explores the role of nasal bacteria and provides clues to developing better flu, COVID-19 vaccines

New rapid test for understanding immunity against COVID-19

In Southeast Asia, robust immunity found up to 9 months after SARS-CoV-2 infection

Vaccinating previously infected induces more potent antibodies less susceptible to escape from SARS-CoV-2 variants

Tool for defining new SARS-CoV-2 spike nucleotide sequences to Pango lineage sets

Small protein prevents immune system from destroying pancreatic cells in type 1 diabetes-prone mice

Penn researchers reveal complex details of T-cell responses to mRNA COVID-19 vaccines

Obtained SARS-CoV-2 immunity, naturally or via vaccination persists 12 months

Response to a third SARS-CoV-2 vaccine dose amongst immunocompromised

Researchers assess the genetic features of T-cell immunity development to SARS-CoV-2 variants

Primate study shows benefit of mRNA vaccine booster shot against SARS-CoV-2 variants

First dose of COVID-19 vaccine to be offered to all young people aged 16 to 17 in England

Modeling the spread and development of SARS-CoV-2 outbreaks in the US

Role of neutrophil-epithelial interactions in SARS-CoV-2 infection

Utah warns of Delta variant eroding COVID vaccine effectiveness

Certain intestinal bacteria induce cross-reactive IgA responses to the SARS-CoV-2 spike RBD

World-first trial of third dose COVID-19 booster vaccine shows improved protection in transplant patients

Enzyme acts as a sensor to find the hiding spots of viruses

Exploring Strategies for Targeting Kinases in Innate Immunity eBook

Decoding Cannabis: Differentiating Hemp and Marijuana

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

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