immunity News and Research

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Calls for humanitarian pause to safeguard polio vaccination efforts in Gaza

Two rounds of a polio vaccination campaign are expected to be launched at the end of August and September 2024 across the Gaza Strip to prevent the spread of circulating variant type 2 poliovirus (cVDPV2).

18 Aug 2024

New study reveals overlap between metabolic and immune disorders

Inherited diseases of metabolism and immunity have more in common than previously recognized, according to a new study published in the journal Science Immunology.

16 Aug 2024

Understanding host immune responses through cell death pathways

A new review was published as the cover paper of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 15, entitled, "Types of cell death and their relations to host immunological pathways".

16 Aug 2024

Ribonucleic acid for injection II enhances immunity and hematopoiesis in immunosuppressed mice

Announcing a new publication for Acta Materia Medica journal. Ribonucleic acid for injection II is a clinical adjuvant cancer therapy treatment based on immunotherapy, which exerts its effects by enhancing immune function and suppressing tumor growth.

16 Aug 2024

Impact of physical activity on gut microbiota in irritable bowel syndrome

The impact of different types and intensities of physical exercise on the gut microbiota and symptom alleviation in patients with irritable bowel syndrome.

14 Aug 2024

New targets for improved cancer immunotherapy

In the past two decades, immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, showing promising results against various solid tumors. This study reviews recent developments in ICIs, focusing on new targets like T cell immunoreceptors with Ig and ITIM domains (TIGIT), T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3), and lymphocyte activation gene-3 (LAG-3). These targets aim to overcome resistance mechanisms limiting the effectiveness of current therapies, such as anti-PD-1 and anti-CTLA-4. By identifying and developing these new ICIs, researchers hope to improve treatment outcomes and provide new therapeutic options for cancer patients.

14 Aug 2024

Novel vaccination strategy shows promise in boosting immunity and controlling influenza spread in pigs

Study demonstrates that a novel prime/boost vaccination protocol using live-attenuated influenza vaccines effectively induces strong immune responses in pigs, offering a promising approach for future influenza vaccination strategies.

13 Aug 2024

Two studies uncover how immunotherapies work together to activate immune responses in melanoma

Two studies published in the latest issue of the journal Cell by University of Pittsburgh researchers uncover how immunotherapies targeting the immune checkpoints PD1 and LAG3 work together to activate immune responses.

13 Aug 2024

Prioritizing older individuals for COVID-19 boosters yields best public health outcomes, study finds

Whether prioritizing older individuals for COVID-19 booster vaccinations consistently leads to optimal public health outcomes across diverse socio-economic settings.

13 Aug 2024

Study uncovers OLAH as key driver of fatal respiratory disease

Respiratory infections can be severe, even deadly, in some individuals, but not in others.

12 Aug 2024

New antibody treatment shows promise in preventing heart transplant rejection

A new study from scientists at Cincinnati Children's suggests there may be a way to further protect transplanted hearts from rejection by preparing the donor organ and the recipient with an anti-inflammatory antibody treatment before surgery occurs.

12 Aug 2024

Study reveals how light-activated macrophages increase their appetite for cancer cells

The body has a veritable army constantly on guard to keep us safe from microscopic threats from infections to cancer.

12 Aug 2024

Does cannabis use disorder increase the risk of head and neck cancer?

Researchers determine whether cannabis use disorder increases the risk of head and neck cancer.

12 Aug 2024

Brain circuits connecting stress to gut bacteria reveal new pathways for immune regulation

Researchers have discovered a brain-gut circuit that links stress to changes in gut bacteria, revealing that emotional states can directly influence immune function through the duodenal glands.

11 Aug 2024

Cross-reactive T cells link SARS-CoV-2 to autoimmune triggers in MIS-C

Research identifies cross-reactive T cells targeting both SARS-CoV-2 and human SNX8 protein, providing insights into the autoimmune mechanisms driving MIS-C in children.

8 Aug 2024

Insilico Medicine's pan-TEAD inhibitor ISM6331 receives FDA IND clearance for mesothelioma treatment

Insilico Medicine ("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven biotechnology company, today announced ISM6331, potential best-in-class pan-TEAD inhibitor, has received the U.S. Food and Drug Administration (FDA) Investigational New Drug (IND) clearance for the treatment of mesothelioma, following the grant of Orphan Drug Designation (ODD) in June 2024. It brings the total number of IND-approved molecules of Insilico to nine.

8 Aug 2024

Prenatal famine exposure tied to higher risk of Type 2 diabetes

Researchers at Columbia University Mailman School of Public Health, the University of North Carolina at Chapel Hill and at the National Academy of Sciences of Ukraine used the setting of the man-made Ukrainian Holodomor famine of 1932-1933 to examine the relation between prenatal famine and adult Type 2 diabetes mellitus (T2DM).

8 Aug 2024

Many children with recurrent wheezing have "silent" lung infections, research reveals

Nearly a quarter of children with recurrent wheezing have "silent" lung infections that would be better treated with antiviral medications than commonly prescribed steroids that can carry lifelong side effects, new research from the University of Virginia School of Medicine reveals.

8 Aug 2024

METRNL protein identified as key player in cancer progression

A protein called Meteorin-like (METRNL) in the tumor microenvironment saps energy from T cells, thereby severely limiting their ability to fight cancer, according to new research directed by investigators at the Johns Hopkins University School of Medicine and the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy. Finding ways to block the effects of METRNL signaling on tumor-infiltrating T cells may allow these immune cells to regain the energy necessary to eliminate tumors.

7 Aug 2024

Potential liver risks from popular herbal supplements revealed in new study

A study in JAMA Network Open reveals that 5% of U.S. adults consume six potentially hepatotoxic botanicals, highlighting a significant need for increased regulatory oversight.

6 Aug 2024

immunity News and Research

Calls for humanitarian pause to safeguard polio vaccination efforts in Gaza

New study reveals overlap between metabolic and immune disorders

Understanding host immune responses through cell death pathways

Ribonucleic acid for injection II enhances immunity and hematopoiesis in immunosuppressed mice

Impact of physical activity on gut microbiota in irritable bowel syndrome

New targets for improved cancer immunotherapy

Novel vaccination strategy shows promise in boosting immunity and controlling influenza spread in pigs

Two studies uncover how immunotherapies work together to activate immune responses in melanoma

Prioritizing older individuals for COVID-19 boosters yields best public health outcomes, study finds

Study uncovers OLAH as key driver of fatal respiratory disease

New antibody treatment shows promise in preventing heart transplant rejection

Study reveals how light-activated macrophages increase their appetite for cancer cells

Does cannabis use disorder increase the risk of head and neck cancer?

Brain circuits connecting stress to gut bacteria reveal new pathways for immune regulation

Cross-reactive T cells link SARS-CoV-2 to autoimmune triggers in MIS-C

Insilico Medicine's pan-TEAD inhibitor ISM6331 receives FDA IND clearance for mesothelioma treatment

Prenatal famine exposure tied to higher risk of Type 2 diabetes

Many children with recurrent wheezing have "silent" lung infections, research reveals

METRNL protein identified as key player in cancer progression

Potential liver risks from popular herbal supplements revealed in new study

Exploring Strategies for Targeting Kinases in Innate Immunity eBook

Decoding Cannabis: Differentiating Hemp and Marijuana

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

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