microOptilab® Refractive Index Detector for UHPLC from Wyatt Technology

The microOptilab® (UHPLC refractometer with extended range) is the first RI detector specifically designed for use with any UHPLC system. It works alone as a universal concentration detector, or in combination with the Wyatt microDAWN™ multi-angle light scattering (MALS) detector to measure absolute molar mass and size of macromolecules and nanoparticles in solution, via µSEC-MALS. Combined with the microDAWN™, the microOptilab can measure macromolecules and nanoparticles from 10-50 nm in size and 200 Da – 10 MDa in molar mass


  • Range: -0.0047 to +0.0047 RIU
  • Sensitivity: 1.5 x 10-9 RIU
  • Temperature control both above and below ambient, from 4°C - 65°C