What is Acetylation?

Acetylation is a chemical reaction that is called ethanoylation in the IUPAC nomenclature. It describes a reaction that introduces an acetyl functional group into a chemical compound. The opposite chemical reaction is called deacetylation – it is the removal of the acetyl group.

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The process of introducing an acetyl group results in an acetoxy group. It involves the substitution of an acetyl group for an active hydrogen atom. A reaction involving the replacement of the hydrogen atom of a hydroxyl group with an acetyl group (CH3 CO) would then yield a specific ester, the acetate.

Which proteins undergo acetylation?

Most of the proteins in the human body undergo acetylation. The process of acetylation is important for several important chemical reactions in the body. This includes:-


N-alpha-acetyltransferases help in mediating acetylation reactions. There are three common varieties of these enzymes. These are labeled A, B, and C and act within the cells to transfer molecules. They also control the proteins that build up the cellular structures.

Further Reading

Written by

Dr. Ananya Mandal

Dr. Ananya Mandal is a doctor by profession, lecturer by vocation and a medical writer by passion. She specialized in Clinical Pharmacology after her bachelor's (MBBS). For her, health communication is not just writing complicated reviews for professionals but making medical knowledge understandable and available to the general public as well.

Last updated Jan 13, 2021


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