Cell Biology

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New technology helps study muscle biology more clearly

Exercising regularly is one of the best defenses against metabolic diseases, such as obesity and diabetes - but why? It's a question that scientists are still struggling to answer. While exercising changes the molecular behavior of muscles, it's not well understood how these molecular changes improve metabolic health.

13 Jan 2021

New taxonomic classification of non-skeletal rare congenital disorders with impact on bone physiology

Thanks to major progress in the understanding and management of rare congenital diseases and syndromes, many patients with these rare disorders are now living longer lives.

13 Jan 2021

Biologists reveal unusual structure of coronavirus protein linked to immune evasion

A team of HIV researchers, cellular biologists, and biophysicists who banded together to support COVID-19 science determined the atomic structure of a coronavirus protein thought to help the pathogen evade and dampen response from human immune cells.

13 Jan 2021

Scientists identify sensor in human lungs that detects SARS-CoV-2

Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified the sensor in human lungs that detects SARS-CoV-2 and signals that it's time to mount an antiviral response.

13 Jan 2021

Daily circadian cycles may impact our ability to fight disease

An analysis of an exhaustive dataset on cells essential to the mammalian immune system shows that our ability to fight disease may rely more heavily on daily circadian cycles than previously assumed.

12 Jan 2021

Scientists determine ideal dose of stem cells to control HIV

Scientists have determined the optimal conditions following a stem cell transplant that could control HIV without the need of an everyday pill, according to a study published today in eLife.

12 Jan 2021

Study shows how brain molecules work in conjunction to create architectural marvels

In a study published in Cell Reports, researchers at Kanazawa University identify pathways in the brain which enable neurons to assemble into functional units resembling tall columns.

12 Jan 2021

Nanobodies have potential to be developed into a treatment for COVID-19

Researchers at Karolinska Institutet in Sweden have developed, in collaboration with researchers in Germany and the U.S., new small antibodies, also known as nanobodies, which prevent the SARS-CoV-2 coronavirus from entering human cells.

12 Jan 2021

Boosting a natural cellular process could lower ventilator-related lung damage

An unfortunate truth about the use of mechanical ventilation to save the lives of patients in respiratory distress is that the pressure used to inflate the lungs is likely to cause further lung damage.

12 Jan 2021

Advanced humanized mouse model helps better understand immunotherapy resistance in melanoma

Scientists at The Wistar Institute have created an advanced humanized immune system mouse model that allows them to examine resistance to immune checkpoint blockade therapies in melanoma. It has revealed a central role for mast cells. These findings were published today in the journal Nature Communications.

12 Jan 2021

New fluorescence microscopy technique produces nanoscale 3D images of living cells

A new fluorescence microscopy technique has produced the world's first nanoscale 3D images of molecules in a whole, living cell, researchers at KTH Royal Institute of Technology reported.

12 Jan 2021

Researchers determine the atomic structure of protein that helps coronavirus to evade immune cells

12 Jan 2021

Researchers develop improved process for large-scale electron microscopy to visualize small structures

How are networks of neurons connected to make functional circuits? This has been a long-standing question in neuroscience. To answer this fundamental question, researchers from Boston Children's Hospital and Harvard Medical School developed a new way to study these circuits and in the process learn more about the connections between them.

12 Jan 2021

Researchers develop new technique to more efficiently isolate and identify rare T cells

Scientists from the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have developed a technique that will enable researchers to more efficiently isolate and identify rare T cells that are capable of targeting viruses, cancer and other diseases.

12 Jan 2021

Researchers develop a novel, patient-derived model of ulcerative colitis

As reported in Nature Communications, researchers from Cleveland Clinic's Lerner Research Institute have developed a novel, patient-derived model of ulcerative colitis, which will help advance studies into new treatments for the chronic inflammatory bowel disease.

11 Jan 2021

Study monitors spatial shifts of liver gene expression in relationship to the circadian clock

Nothing in biology is static. Biological processes fluctuate over time, and if we are to put together an accurate picture of cells, tissues, organs etc., we have to take into account their temporal patterns. In fact, this effort has given rise to an entire field of study known as "chronobiology".

11 Jan 2021

Researchers demonstrate SARS-CoV-2 infection in human lung bronchioalveolar tissue model

Development of an in vitro human-derived tissue model for studying virus infection and disease progression in the alveolar cells of the lungs responsible for oxygen and carbon dioxide exchange with the blood might enable the study of possible therapies for acute respiratory distress syndrome (ARDS) triggered by SARS-CoV-2.

11 Jan 2021

MDC researchers develop a potent weapon against lymphomas

MDC researchers have developed a new approach to CAR T-cell therapy. The team has shown in Nature Communications that the procedure is very effective, especially when it comes to fighting follicular lymphomas and chronic lymphocytic leukemia, the most common type of blood cancer in adults.

11 Jan 2021

Master Regulator proteins control cancer transcriptional identity

Thousands of different genetic mutations have been implicated in cancer, but a new analysis of almost 10,000 patients found that regardless of the cancer's origin, tumors could be stratified in only 112 subtypes and that, within each subtype, the Master Regulator proteins that control the cancer's transcriptional state were virtually identical, independent of the specific genetic mutations of each patient.

11 Jan 2021

Study shows how intestinal stem cells constantly renew and give rise to specialized cell types

The gut plays a central role in the regulation of the body's metabolism and its dysfunction is associated with a variety of diseases, such as obesity, diabetes, colitis and colorectal cancer that affect millions of people worldwide.

11 Jan 2021

Cell Biology

New technology helps study muscle biology more clearly

New taxonomic classification of non-skeletal rare congenital disorders with impact on bone physiology

Biologists reveal unusual structure of coronavirus protein linked to immune evasion

Scientists identify sensor in human lungs that detects SARS-CoV-2

Daily circadian cycles may impact our ability to fight disease

Scientists determine ideal dose of stem cells to control HIV

Study shows how brain molecules work in conjunction to create architectural marvels

Nanobodies have potential to be developed into a treatment for COVID-19

Boosting a natural cellular process could lower ventilator-related lung damage

Advanced humanized mouse model helps better understand immunotherapy resistance in melanoma

New fluorescence microscopy technique produces nanoscale 3D images of living cells

Researchers determine the atomic structure of protein that helps coronavirus to evade immune cells

Researchers develop improved process for large-scale electron microscopy to visualize small structures

Researchers develop new technique to more efficiently isolate and identify rare T cells

Researchers develop a novel, patient-derived model of ulcerative colitis

Study monitors spatial shifts of liver gene expression in relationship to the circadian clock

Researchers demonstrate SARS-CoV-2 infection in human lung bronchioalveolar tissue model

MDC researchers develop a potent weapon against lymphomas

Master Regulator proteins control cancer transcriptional identity

Study shows how intestinal stem cells constantly renew and give rise to specialized cell types

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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