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Greasing the gears that drive the interferon signal

Interferon -- a critical protein that mediates the body's defense against a wide variety of infectious agents and tumors -- may soon have greater therapeutic value as the result of a new study by researchers at Washington University School of Medicine in St. Louis.

3 Oct 2005

Study shows that high-fat diets correlate to a chronic inflammatory state in the liver,

Mice that were fed diets high in fat and sugar developed immune system abnormalities in their livers, including reduced numbers of natural killer T (NKT) cells. These diet-related changes may contribute to obesity-related liver disease, according to a new study.

3 Oct 2005

Potential beneficial effect of copper orotate

As one of the services for patients with Alzheimer's disease, the Department of Psychiatry at the Saarland University Medical Center offers participation in a clinical phase II trial. This clinical trial aims to elucidate a potential beneficial effect of copper orotate (an organic copper salt), which is given together with a standard cholinesterase inhibitor.

3 Oct 2005

Ubiquitin ligase Rnf6 may be involved in oncogenesis

In a recent study, Dr. Ingolf Bach and colleagues from the University of Massachusetts Medical School, Worcester and the University of Hamburg describe a novel role for the ubiquitin/proteosome protein degradation pathway in the regulation of local actin dynamics in neurons.

3 Oct 2005

Steroids significantly reduce heart damage in children with Kawasaki's disease

When added to standard treatment, steroids significantly reduce the odds of developing heart damage in children with Kawasaki's disease, according to a study in the October issue of Pediatrics. These findings address a gap in knowledge.

3 Oct 2005

Misoprostol could play an important part in reducing complications of delivery in developing countries

A relatively cheap and easy to use drug could save the lives of thousands of women in the developing world, according to a study in this week's British Medical Journal.

3 Oct 2005

First identification of the genetic basis of disease in a patient with a complex I assembly defect

Mitochondrial complex I deficiency is one of the most common defects in patients with mitochondrial disease. The deficiency results from a failure to assemble the enzyme properly, but the nature of the molecular chaperones that are necessary for this process in mammals have remained obscure.

3 Oct 2005

Microarray technology may help tailor breast cancer therapy

Microarray technology could be used to tailor therapy according to the individual, and prevent breast cancer patients from having to undergo painful unsuccessful therapies.

3 Oct 2005

Speeding up fetal MRIs

A modified technique that uses the eyes as the line of reference means a 50 percent reduction in the time necessary to take MRI images of the fetal brain.

3 Oct 2005

Concerta, a once-daily form of the drug methylphenidate, successfully controlled ADHD symptoms

A new study has found that an all-day, extended-release stimulant for treating attention-deficit hyperactivity disorder (ADHD) remains effective for up to two years without significant side effects.

3 Oct 2005

Attitudes of a peer group are more influential than a group that is not as closely allied

According to a study at Yale, one of the most effective ways to change negative attitudes about obese people is by addressing perceptions of normative beliefs within particular social groups.

3 Oct 2005

Physical activity may reduce gastrointestinal symptoms in people who are obese

In a study published in the American Gastroenterological Association (AGA) journal Clinical Gastroenterology and Hepatology, researchers found that a high body mass index (BMI) and lack of physical activity were associated with an increase in GI symptoms such as stomach pain, diarrhea, constipation and irritable bowel syndrome (IBS).

3 Oct 2005

No specific antiretroviral drug-related "Crix belly" syndrome

Contrary to the concerns of many HIV-infected patients, there appears to be no specific antiretroviral drug-related "syndrome" of changes in body fat distribution in men wherein leg and arm fat decrease as belly fat increases, reports a study in the October issue of Journal of Acquired Immune Deficiency Syndromes (JAIDS).

28 Sep 2005

Housework has an adverse effect on wages

While prior research has shown that housework has an adverse effect on wages, a new University of Michigan study finds that only young and middle-aged women are affected.

28 Sep 2005

Salivary antimicrobial peptide expression and dental caries experience in children

A study comparing antimicrobial peptides, or AMPs, a group of small proteins that occur naturally in human saliva and act like antibiotics against oral bacteria, could lead to new ways to screen children for risk of tooth decay and protect them against this common, chronic problem.

28 Sep 2005

Time-to-treatment is important to success of angioplasty treatment

An in-depth look at hospitals that reduced treatment delays highlights steps other hospitals could take to provide rapid angioplasty treatment to heart attack patients, according to a new study in the Oct. 4, 2005, issue of the Journal of the American College of Cardiology.

28 Sep 2005

Flavanols help smokers repair blood vessel function

Phytochemicals known as flavanols, which are found in chocolate, fruits and vegetables, can boost the levels of nitric oxide in the blood of smokers and reverse some of their smoking-related impairment in blood vessel function, according to a new study in the Oct. 4, 2005, issue of the Journal of the American College of Cardiology.

28 Sep 2005

People who receive a kidney transplant are nearly four times more likely to develop melanoma

...a rare but deadly form of skin cancer, according to a study led by Christopher Hollenbeak, Ph.D., associate professor, Departments of Surgery and Health Evaluation Sciences, Penn State College of Medicine, Penn State Milton S. Hershey Medical Center.

28 Sep 2005

Working in a pub can be hazardous to your health

Too much time in the tavern can be hazardous to your health--and not just for the drinkers bending their elbows or scrapping with the bouncer, according to a new study done in part at the University of Alberta.

28 Sep 2005

Alcoholics who smoke appear to lose more brain mass than alcoholics who don't smoke

It is already well-known that the brains of long-term alcoholics atrophy and shrink, the study authors say, but the new findings are the first evidence that cigarette smoking might contribute to that atrophy, particularly in grey matter of the parietal and temporal lobes.

28 Sep 2005

Drug Trial News

Greasing the gears that drive the interferon signal

Study shows that high-fat diets correlate to a chronic inflammatory state in the liver,

Potential beneficial effect of copper orotate

Ubiquitin ligase Rnf6 may be involved in oncogenesis

Steroids significantly reduce heart damage in children with Kawasaki's disease

Misoprostol could play an important part in reducing complications of delivery in developing countries

First identification of the genetic basis of disease in a patient with a complex I assembly defect

Microarray technology may help tailor breast cancer therapy

Speeding up fetal MRIs

Concerta, a once-daily form of the drug methylphenidate, successfully controlled ADHD symptoms

Attitudes of a peer group are more influential than a group that is not as closely allied

Physical activity may reduce gastrointestinal symptoms in people who are obese

No specific antiretroviral drug-related "Crix belly" syndrome

Housework has an adverse effect on wages

Salivary antimicrobial peptide expression and dental caries experience in children

Time-to-treatment is important to success of angioplasty treatment

Flavanols help smokers repair blood vessel function

People who receive a kidney transplant are nearly four times more likely to develop melanoma

Working in a pub can be hazardous to your health

Alcoholics who smoke appear to lose more brain mass than alcoholics who don't smoke

How innovation in dried blood spot testing is transforming neurological disease monitoring

Unlocking live single-cell functional insights

How microRNA is transforming science: From discovery to diagnostics

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