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New hope for patients with metastatic melanoma

Patients with metastatic melanoma (MM) have new hope, says a recently published study by Mayo Clinic Cancer Center. The study, which shows the combination of paclitaxel and carboplatin (PC) appears to be effective for MM when traditional treatments have failed, is in this month's issue of Cancer.

6 Jan 2006

New technique points to safer, more efficient vaccination

Researchers have demonstrated a technique that has the potential to reduce the toxicity of vaccines and to make smaller doses more effective, according to a study published in PLoS Pathogens.

6 Jan 2006

Ethnic minority groups must be included in European health research

Despite the knowledge that ethnicity matters in cardiovascular disease, most studies of cardiovascular disease risk have not been designed to yield results that apply to different ethnic groups, report Meghna Ranganathan and Raj Bhopal (of Edinburgh University) in a new study in the international open-access medical journal PLoS Medicine.

6 Jan 2006

Delivering chemotherapy directly into the abdomen boosts survival in ovarian cancer patients

A 50-year-old method for delivering chemotherapy directly into the abdomen is making a comeback as investigators have found that it increases survival - by more than a year - in some women with advanced ovarian cancer. Results from a seven-year study of more than 400 patients nationwide are published in the New England Journal of Medicine.

6 Jan 2006

Risk factors for nongonococcal urethritis

The study, by Australian researchers Catriona Bradshaw, MD, and colleagues at the Melbourne Sexual Health Centre, is the first major case-control study to simultaneously address all currently hypothesized causes of NGU.

6 Jan 2006

Rotateq eliminates the most severe cases of rotavirus

In a study of more than 68,000 infants published in the New England Journal of Medicine, the investigational vaccine Rotateq demonstrated that it can safely prevent 98 percent of severe cases of viral diarrhea and vomiting that account for 2 million hospital visits and 500,000 pediatric deaths each year worldwide.

6 Jan 2006

alphaB-crystallin may be a useful molecular marker to identify women with aggressive breast cancer

A groundbreaking study led by Northwestern University researchers has demonstrated that a protein called alphaB-crystallin, which normally protects cells from stress damage, triggers events that may cause breast cancer when overactive.

6 Jan 2006

Soy diet worsens heart disease in mice

Researchers from the University of Colorado have shown that mice carrying a genetic mutation that is linked to altered heart growth and function in humans, have significantly worse heart problems if fed a soy diet, when compared to mice fed a soy-free (milk protein-based) diet.

6 Jan 2006

Hopkins discovery provides molecular marker to assess risk for patients with papillary thyroid cancer

Scientists at Johns Hopkins have found that a mutation in the gene that triggers production of a tumor growth protein is linked to poorer outcomes for patients with papillary thyroid cancer (PTC).

6 Jan 2006

Smoking during pregnancy increases risk of having a child with missing fingers and toes

In the largest study of its kind, plastic surgeons found smoking during pregnancy significantly elevates the risk of having a child with excess, webbed or missing fingers and toes, according to the January issue of Plastic and Reconstructive Surgery, the official medical journal of the American Society of Plastic Surgeons (ASPS).

6 Jan 2006

Exposure to infections at birth can trigger brain damage and the development of cerebral palsy

Exposure to certain viral infections shortly before and after birth (the perinatal period) is associated with cerebral palsy, finds a study published online by the British Medical Journal.

6 Jan 2006

Cyclosporine suppresses hepatitis C virus and increases the chance of a sustained virological response after liver transplantation

Liver transplant patients with hepatitis C virus (HCV) achieved significantly better long-term viral response when taking the immunosuppressive agent Cyclosporine along with interferon-ribavirin combination therapy. Cyclosporine also showed efficacy against Hepatitis C virus in vitro.

5 Jan 2006

New pathways linking liver disease to changes in the central nervous system

Liver disease is often associated with "sickness behaviors," such as malaise, listlessness, anorexia, difficulty concentrating, and fatigue. In cholestatic liver diseases (where bile production is impaired) such as primary biliary cirrhosis, fatigue occurs in up to 86 percent of patients.

5 Jan 2006

Limitation of combination therapy of Interferon and Ribavirin for older patients with chronic hepatitis C

A new Japanese study examining the effects of combination therapy on older patients with hepatitis C found more adverse effects necessitating discontinuation of treatment, lowering of dosages, and lower long-term benefits in this age group.

5 Jan 2006

Herceptin may work better when it is followed by injections of interleukin

A new study suggests that antibody-based cancer drugs might help patients more if they are given with substances that stimulate the immune system.

5 Jan 2006

Children more likely to survive in-hospital cardiac arrests than adults

Children are more likely to survive in-hospital cardiac arrests than adults and with appropriate cardiopulmonary resuscitation (CPR), the survival rates for both children and adults are higher than previously thought.

5 Jan 2006

Elevated homocysteine levels may be a biomarker for increased risk of AMD

People who have elevated homocysteine in their blood, an amino acid that is a known biomarker for cardiovascular disease, may also be at an increased risk of developing age-related macular degeneration (AMD), according to a study in the January issue of the American Journal of Ophthalmology.

5 Jan 2006

Exercise helps elderly heal

The body's ability to heal even small skin wounds normally slows down as we age. But a new study in older adults finds that regular exercise may speed up the wound-healing process by as much as 25 percent.

5 Jan 2006

NEJM rotavirus studies: statement by PATH's Rotavirus Vaccine Program

On Thursday, January 5, the New England Journal of Medicine published the results of two important clinical trials of rotavirus vaccines.

4 Jan 2006

Reduced rates of lung function decline in cystic fibrosis clinical study patients

Although cystic fibrosis patients in clinical trials had more severe illness, worse lung function, a lower weight level and more respiratory infection than non-participants, their involvement in research studies resulted in less lung function decline over a 7-year period.

2 Jan 2006

Drug Trial News

New hope for patients with metastatic melanoma

New technique points to safer, more efficient vaccination

Ethnic minority groups must be included in European health research

Delivering chemotherapy directly into the abdomen boosts survival in ovarian cancer patients

Risk factors for nongonococcal urethritis

Rotateq eliminates the most severe cases of rotavirus

alphaB-crystallin may be a useful molecular marker to identify women with aggressive breast cancer

Soy diet worsens heart disease in mice

Hopkins discovery provides molecular marker to assess risk for patients with papillary thyroid cancer

Smoking during pregnancy increases risk of having a child with missing fingers and toes

Exposure to infections at birth can trigger brain damage and the development of cerebral palsy

Cyclosporine suppresses hepatitis C virus and increases the chance of a sustained virological response after liver transplantation

New pathways linking liver disease to changes in the central nervous system

Limitation of combination therapy of Interferon and Ribavirin for older patients with chronic hepatitis C

Herceptin may work better when it is followed by injections of interleukin

Children more likely to survive in-hospital cardiac arrests than adults

Elevated homocysteine levels may be a biomarker for increased risk of AMD

Exercise helps elderly heal

NEJM rotavirus studies: statement by PATH's Rotavirus Vaccine Program

Reduced rates of lung function decline in cystic fibrosis clinical study patients

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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