Genomics

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Researchers identify a gene that could prevent Parkinson’s disease

Parkinson's disease is a neurodegenerative disorder characterized by the destruction of a specific population of neurons: the dopaminergic neurons.

17 Mar 2022

Tracking the mutating coronavirus variants

Viruses continuously and naturally evolve. To track coronavirus variants, we need to think like Darwin.

16 Mar 2022

Study reveals how to identify and avoid risks related to mitochondrial therapeutic interventions

Research carried out at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has demonstrated that mixing mitochondrial DNAs (mtDNAs) of different origins can have damaging effects over the medium and long term.

16 Mar 2022

Study takes a new approach to looking at de novo genetic variants in autism

About 1 in 44 children in the U.S. are diagnosed with autism spectrum disorder (ASD) by the age of 8, according to the 2018 Centers for Disease Control and Prevention surveillance. How a child's DNA contributes to the development of ASD has been more of a mystery.

15 Mar 2022

First genetic rat model of Down syndrome offers better understanding of the condition

In pursuit of better ways to test new therapies and further explore the impacts of the unique genetics associated with Down syndrome, researchers at Johns Hopkins Medicine and Tottori University in Japan have genetically engineered and characterized what is believed to be the first rat model of Down syndrome.

14 Mar 2022

Bioactive small molecules enhance CRISPR/Cas9 loss-of-function editing in human cells

Researchers demonstrate enhanced loss-of-function editing of CRISPR/Cas9 in human cells.

14 Mar 2022

UCI researchers reveal new details about a key enzyme that makes DNA sequencing possible

In a paper published today in Sciences Advances, researchers in the Department of Chemistry and the Department of Physics & Astronomy at the University of California, Irvine revealed new details about a key enzyme that makes DNA sequencing possible.

12 Mar 2022

Scientists identify a new protein that turbocharges gene expression

For many years, scientists have sought to understand what happens when our genes are flipped to the "on" position. Now, scientists at the University of California San Diego and Rutgers University have identified a new protein that contributes to this important process.

11 Mar 2022

Genomic surveillance of bacterial colonies could help physicians keep closer tabs on drug resistance

Antibiotic-resistant bacterial infections are difficult to treat and cause more than a million annual deaths worldwide, especially in hospitalized patients with pneumonia, bloodstream infections, urinary tract infections, or abdominal infections.

11 Mar 2022

Novel strategy for data sharing may help better understand disease-causing genetic variants

Scientists may better understand and test for the genetic variations that cause cancer and other heritable diseases through the application of a novel strategy for securely sharing and analyzing genomic data developed at the UC Santa Cruz Genomics Institute.

10 Mar 2022

Study reveals differential blood glycoprotein profiles in symptomatic and asymptomatic COVID-19 patients

A new study used glycoprotein profiling technology platform that couples high-resolution LC-MS for glycoprotein analysis in regards to COVID-19.

9 Mar 2022

CRIPSR identifies cell-type-specific ACE2 modifiers

Researchers compile a list of candidate genes to identify the surface abundance of functional regulators of ACE2.

9 Mar 2022

Intragenomic rearrangements help explain how SARS-CoV-2 variants arise

In a recent study posted to the bioRxiv* preprint server, researchers presented the intragenomic rearrangements of β-coronaviruses (CoVs), including severe acute respiratory syndrome CoV 2 (SARS-CoV-2).

9 Mar 2022

A new view of SARS-CoV-2 genome structure

Researchers performed DMS mutational profiling with sequencing and DREEM clustering to determine the SARS-CoV-2 RNA secondary structure.

8 Mar 2022

How will mutations change the SARS-CoV-2 spike protein in the future?

A new Cells review discusses the factors that affect the function of the SARS-CoV-2 S protein and provides theoretical limits of this viral protein.

8 Mar 2022

Scientists shed light on placenta's role in transferring vitamin D to fetus during pregnancy

Scientists have shed new light on the role of the placenta in managing the relationships between maternal vitamin D and fetal development, according to a study published today in eLife.

8 Mar 2022

Researchers unravel how parent's gene impact the behavior of children

Parenting is not the only way moms and dads impact the behavior of their offspring. Genes matter, too. And although most of our genes are inherited in pairs - one copy from each parent - moms and dads exert their genetic influence in different ways.

8 Mar 2022

Researchers come one step closer to reversing the destructive aging process in egg cells

Throughout much of the world, increasing numbers of women are delaying having their first child until they are in their late thirties, and even into their forties.

8 Mar 2022

Intersectional, anterograde transsynaptic targeting system used to reveal two different brain circuits

Osaka Metropolitan University uses new “intersectional, anterograde transsynaptic targeting system” to reveal two different mouse brain circuits: the retina/primary visual cortex to the superior colliculus and the bilateral motor cortex to the dorsal striatum.

8 Mar 2022

Study offers insight into molecular biology of the brain in bipolar disorder patients

In a comprehensive study involving one of the largest-ever samples of post-mortem brains, scientists at the Lieber Institute for Brain Development, in collaboration with researchers at the Johns Hopkins School of Medicine and Bloomberg School of Public Health, have pinpointed significant differences in gene expression in two specific regions of the brains of hundreds of patients who had bipolar disorder.

7 Mar 2022

Genomics

Researchers identify a gene that could prevent Parkinson’s disease

Tracking the mutating coronavirus variants

Study reveals how to identify and avoid risks related to mitochondrial therapeutic interventions

Study takes a new approach to looking at de novo genetic variants in autism

First genetic rat model of Down syndrome offers better understanding of the condition

Bioactive small molecules enhance CRISPR/Cas9 loss-of-function editing in human cells

UCI researchers reveal new details about a key enzyme that makes DNA sequencing possible

Scientists identify a new protein that turbocharges gene expression

Genomic surveillance of bacterial colonies could help physicians keep closer tabs on drug resistance

Novel strategy for data sharing may help better understand disease-causing genetic variants

Study reveals differential blood glycoprotein profiles in symptomatic and asymptomatic COVID-19 patients

CRIPSR identifies cell-type-specific ACE2 modifiers

Intragenomic rearrangements help explain how SARS-CoV-2 variants arise

A new view of SARS-CoV-2 genome structure

How will mutations change the SARS-CoV-2 spike protein in the future?

Scientists shed light on placenta's role in transferring vitamin D to fetus during pregnancy

Researchers unravel how parent's gene impact the behavior of children

Researchers come one step closer to reversing the destructive aging process in egg cells

Intersectional, anterograde transsynaptic targeting system used to reveal two different brain circuits

Study offers insight into molecular biology of the brain in bipolar disorder patients

Evolving spectrophotometry for modern biopharma workflows

Scaling B-cell cloning workflows for antibody development

Fluidics in Modern Healthcare & Medical Device Innovation

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