Genomics

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Study illustrates how a protein complex controls genome organization to maintain lineage fidelity

Understanding the molecular mechanisms that specify and maintain the identities of more than 200 cell types of the human body is arguably one of the most fundamental problems in molecular and cellular biology, with critical implications for the treatment of human diseases. Central to the cell fate decision process are stem cells residing within each tissue of the body.

29 Apr 2022

New workflow identifies hidden genetic connections that could improve personalized medicine for IBD

All humans carry genetic variations in their DNA, called Single Nucleotide Polymorphisms (SNPs) that can underlie susceptibility to diseases such as diabetes and cancer.

28 Apr 2022

Genetic bottlenecks could impact Wyoming toads' ability to respond to new pathogens

A new study from North Carolina State University examines immune system diversity in the critically endangered Wyoming toad and finds that genetic bottlenecks could impact a species' ability to respond to new pathogens.

28 Apr 2022

Specific genes that play important role in schizophrenia identified

Schizophrenia is a serious psychiatric disorder that starts in late adolescence or early adulthood and affects around 1 in 300 people worldwide, according to the World Health Organization.

28 Apr 2022

DGP student investigates sexual dysmorphism in mice

Isabella Salamone is an eighth-year student in the Driskill Graduate Program in Life Sciences (DGP) who is studying sexual dysmorphism in mice in the laboratory of Elizabeth McNally, MD, PhD, the Elizabeth J. Ward Professor of Genetic Medicine and director of the Center for Genetic Medicine.

28 Apr 2022

Misexpression of non-cardiac genes may lead to congenital heart disease

Inside embryonic cells, specific proteins control the rate at which genetic information is transcribed from DNA to messenger RNA – a crucial regulatory step before proteins are created. Then, organs develop and hopefully function properly.

27 Apr 2022

Researchers use a systems biology approach to parse the genetic diversity of C. difficile

Researchers at University of California San Diego School of Medicine and Jacobs School of Engineering, with colleagues at Baylor College of Medicine, have used a systems biology approach to parse the genetic diversity of Clostridioides difficile, a particularly problematic pathogen in health care settings.

27 Apr 2022

Genetic cause of lupus identified

An international team of researchers has identified DNA mutations in a gene that senses viral RNA, as a cause of the autoimmune disease lupus, with the finding paving the way for the development of new treatments.

27 Apr 2022

Gut virome may warn of a serious and often fatal disease in preterm infants

Immediately after birth, human infants begin to develop a complex, interwoven fabric of microbes in their gut.

26 Apr 2022

Genetic variations in critical mitochondrial enzyme play a role in age-related mobility changes

Age-related changes in strength and mobility may depend on genetic variations in a critical mitochondrial enzyme, suggests a study published today in eLife.

26 Apr 2022

Researchers develop new platform capable of mitochondrial DNA editing

Researchers from the Center for Genome Engineering within the Institute for Basic Science developed a new gene-editing platform called transcription activator-like effector-linked deaminases, or TALED.

25 Apr 2022

DNA analysis of tumors uncovers a 'treasure trove' of clues about the causes of cancer

DNA analysis of thousands of tumors from NHS patients has found a 'treasure trove' of clues about the causes of cancer, with genetic mutations providing a personal history of the damage and repair processes each patient has been through.

21 Apr 2022

Researchers discover more needles in the haystack in the quest to unravel Alzheimer’s disease

21 million. That's the number of genetic variations in the human genome that researchers are sifting to identify patterns predisposing people to Alzheimer's disease.

20 Apr 2022

Single-cell genome sequencing provides a new way to think about Alzheimer’s disease

Alzheimer's disease is marked by a loss of functional neurons in the brain. But what causes this loss? Through single-cell genome sequencing, researchers at Boston Children's Hospital, Brigham and Women's Hospital, and the Broad Institute show that people with Alzheimer's have an abundance of newly acquired mutations in their neurons - more than people of the same age without Alzheimer's, and enough to disable genes important to brain function.

20 Apr 2022

Novel targets for treating sorafenib-resistant hepatocellular carcinoma found using CRISPR-Cas9 screening

This study is led by Xiujun Cai (Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine). Professor Xiujun Cai's research team screened the whole genome of hepatocellular carcinoma cells (HepG2) through CRISPR / cas9 system under sorafenib treatment, and screened the dominant gene in sorafenib resistance.

20 Apr 2022

Genomics

Study illustrates how a protein complex controls genome organization to maintain lineage fidelity

New workflow identifies hidden genetic connections that could improve personalized medicine for IBD

Genetic bottlenecks could impact Wyoming toads' ability to respond to new pathogens

Specific genes that play important role in schizophrenia identified

DGP student investigates sexual dysmorphism in mice

Misexpression of non-cardiac genes may lead to congenital heart disease

Researchers use a systems biology approach to parse the genetic diversity of C. difficile

Genetic cause of lupus identified

Gut virome may warn of a serious and often fatal disease in preterm infants

Genetic variations in critical mitochondrial enzyme play a role in age-related mobility changes

Researchers develop new platform capable of mitochondrial DNA editing

DNA analysis of tumors uncovers a 'treasure trove' of clues about the causes of cancer

Researchers discover more needles in the haystack in the quest to unravel Alzheimer’s disease

Single-cell genome sequencing provides a new way to think about Alzheimer’s disease

Novel targets for treating sorafenib-resistant hepatocellular carcinoma found using CRISPR-Cas9 screening

Small genetic differences can affect the ability to utilize energy of various nutrients, study finds

Researchers develop and validate polygenic risk scores for six common diseases

Research shines light on the effects of genomic variation on gut microbiome function

Two strains of TB bacterium attack the lungs in completely different fashion, study finds

RNA interference triggers that target SARS-CoV-2 genome

Evolving spectrophotometry for modern biopharma workflows

Scaling B-cell cloning workflows for antibody development

Fluidics in Modern Healthcare & Medical Device Innovation

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