Genomics

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Worldwide study of diverse populations sheds new light on how genes contribute to type 2 diabetes

Ongoing worldwide research of diverse populations by an international team of scientists, including a University of Massachusetts Amherst genetic epidemiologist, has shed important new light on how genes contribute to type 2 diabetes.

12 May 2022

Repeated DNA sequences in the genome may contribute to schizophrenia risk

Researchers at The Hospital for Sick Children (SickKids) and Centre for Addiction and Mental Health (CAMH) have found that repeated DNA sequences in the genome may contribute to an individual's risk of developing schizophrenia.

12 May 2022

General Internal Medicine and Geriatrics officially separated into two divisions

The Department of Medicine's Division of General Internal Medicine and Geriatrics have been officially separated into two divisions, the Division of Geriatrics and the Division of General Internal Medicine, effective March 1, 2022.

12 May 2022

Researchers find gene that shapes mutation rate in mice

Every organism is born with a few mutations in their genome that differ genetically from both of their parents.

11 May 2022

Hypermutation in children could be linked to the biological father receiving chemotherapy treatments

Some rare cases of higher genetic mutation rates in children, known as hypermutation, could be linked to the father receiving certain chemotherapy treatments, new research has found.

11 May 2022

Deficiency of YWHAZ gene alters neurodevelopmental process in zebrafish

An article published in the journal Molecular Psychiatry reveals the molecular mechanisms to explain how the YWHAZ gene –related to psychiatric and neurological disorders such as autism and schizophrenia– can alter the neurodevelopmental process.

10 May 2022

Study finds link between hippocampal defects and intellectual disability in children with Joubert Syndrome

An important link has been found between the intellectual disability experienced by children with the rare disease Joubert Syndrome (JS) and defects in the hippocampus.

10 May 2022

Better understanding of hybrid parasite strains could improve Chagas disease diagnosis

Researchers at Karolinska Institutet in Sweden have mapped how the parasite Trypanosoma cruzi forms new variants that are more effective at evading the immune system and causing disease.

10 May 2022

Postnatal gene therapy may be able to prevent or reverse deadly effects of Pitt-Hopkins syndrome

UNC School of Medicine Scientists have shown for the first time that postnatal gene therapy may be able to prevent or reverse many deleterious effects of a rare genetic disorder called Pitt-Hopkins syndrome.

10 May 2022

Gene therapy effectively reduces neuropathic pain in mice with spinal cord injuries

An international team of researchers, led by scientists at University of California San Diego School of Medicine, report that a gene therapy that inhibits targeted nerve cell signaling effectively reduced neuropathic pain with no detectable side effects in mice with spinal cord or peripheral nerve injuries.

9 May 2022

Inversions in the human genome found to be more common than previously thought

Researchers at EMBL Heidelberg found that inversions in the human genome are more common than previously thought, which impacts our understanding of certain genetic diseases.

6 May 2022

New technique can accurately detect viruses in tumors from clinical next-generation sequencing

Researchers have developed a method to accurately detect viruses from clinical next-generation sequencing and describe novel associations between specific tumors and viruses that warrant further investigation.

5 May 2022

New method improves polygenic prediction of disease risk across diverse populations

Polygenic risk scores (PRS) are promising tools for predicting disease risk, but current versions have built-in bias that can affect their accuracy in some populations and result in health disparities.

5 May 2022

New model can predict drug-drug interactions based on drug-induced gene expression signatures

Prescriptions for multiple drugs, or polypharmacy, is often recommended for the treatment of complex diseases.

4 May 2022

Benefits of endurance exercise in primary mitochondrial disease depend on the underlying mutation

Mitochondria serve as the main source of energy production in our cells, and endurance exercise is generally known to improve the function of mitochondria.

4 May 2022

Experts develop new method to control gene expression using electrical signals

Researchers have created an improved method for turning genes on and off using electrical signals.

4 May 2022

Study offers a path to closing the knowledge gap about differences in breast cancer genes

Too many women are getting unnecessary mastectomies and other invasive procedures because of a knowledge gap about differences in cancer genes. A new study offers a path to closing the gap.

4 May 2022

Novel genetic mapping study traces links between DNA variations and blood proteins

A new genetic mapping study led by researchers at the Johns Hopkins Bloomberg School of Public Health traces links between DNA variations and thousands of blood proteins in two large and distinct populations. The results should help researchers better understand the molecular causes of diseases and identify proteins that could be targeted to treat these diseases.

3 May 2022

New technology to make temporary genetic modifications tested in mosquitoes

Texas A&M AgriLife Research scientists have tested a technology to make temporary genetic modifications in mosquitoes. The modifications self-delete over time.

3 May 2022

New method increases efficiency of gene editing while minimizing DNA deletion sizes

Wake Forest Institute for Regenerative Medicine (WFIRM) scientists working on CRISPR/Cas9-mediated gene editing technology have developed a method to increase efficiency of editing while minimizing DNA deletion sizes, a key step toward developing gene editing therapies to treat genetic diseases.

2 May 2022

Genomics

Worldwide study of diverse populations sheds new light on how genes contribute to type 2 diabetes

Repeated DNA sequences in the genome may contribute to schizophrenia risk

General Internal Medicine and Geriatrics officially separated into two divisions

Researchers find gene that shapes mutation rate in mice

Hypermutation in children could be linked to the biological father receiving chemotherapy treatments

Deficiency of YWHAZ gene alters neurodevelopmental process in zebrafish

Study finds link between hippocampal defects and intellectual disability in children with Joubert Syndrome

Better understanding of hybrid parasite strains could improve Chagas disease diagnosis

Postnatal gene therapy may be able to prevent or reverse deadly effects of Pitt-Hopkins syndrome

Gene therapy effectively reduces neuropathic pain in mice with spinal cord injuries

Inversions in the human genome found to be more common than previously thought

New technique can accurately detect viruses in tumors from clinical next-generation sequencing

New method improves polygenic prediction of disease risk across diverse populations

New model can predict drug-drug interactions based on drug-induced gene expression signatures

Benefits of endurance exercise in primary mitochondrial disease depend on the underlying mutation

Experts develop new method to control gene expression using electrical signals

Study offers a path to closing the knowledge gap about differences in breast cancer genes

Novel genetic mapping study traces links between DNA variations and blood proteins

New technology to make temporary genetic modifications tested in mosquitoes

New method increases efficiency of gene editing while minimizing DNA deletion sizes

Evolving spectrophotometry for modern biopharma workflows

Scaling B-cell cloning workflows for antibody development

Fluidics in Modern Healthcare & Medical Device Innovation

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