Genomics

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Scientists study how different genes dance to the circadian rhythm

In 2017, the Nobel Prize in Physiology or Medicine went to three scientists who uncovered the molecular mechanisms that control the circadian rhythm, otherwise known as the "wake-sleep" cycle.

29 Jan 2021

New method identifies important mutations behind hereditary non-polyposis colorectal cancer

Colorectal cancer is the third most common form of cancer. While 90% of cases are in people older than 50, there is an as-yet unexplained rising incidence in younger people.

29 Jan 2021

Researchers release first Japanese reference genome

The Japanese now have their own reference genome thanks to researchers at Tohoku University who completed and released the first Japanese reference genome (JG1).

29 Jan 2021

NEI scientists develop and test a promising gene therapy strategy for rare eye disease

Scientists at the National Eye Institute have developed a promising gene therapy strategy for a rare disease that causes severe vision loss in childhood.

28 Jan 2021

Study uncovers genetic similarities between PTSD and other mental health disorders

Attempts to identify the genetic causes of neuropsychiatric diseases such as post-traumatic stress disorder (PTSD) through large-scale genome-wide analyses have yielded thousands of potential links.

28 Jan 2021

Study uncovers rare genetic syndrome caused by mutations in gene SATB1

Advances in DNA sequencing have uncovered a rare syndrome which is caused by variations in the gene SATB1.

28 Jan 2021

Genomic studies give new insights into the biological basis of PTSD

After analyzing the genomes of more than one-quarter of a million military veterans, a team of scientists, led by researchers at University of California San Diego, Veterans Affairs San Diego Healthcare System (VASDHS), Yale University and West Haven VA, have identified 18 specific, fixed positions on chromosomes (known as loci) that appear associated with post-traumatic stress disorder (PTSD).

28 Jan 2021

Study shows how aneuploidy could become a weak point for cancer cells

What makes cancer cells different from ordinary cells in our bodies? Can these differences be used to strike at them and paralyze their activity? This basic question has bothered cancer researchers since the mid-19th century.

27 Jan 2021

Researchers develop new computational method for studying genetic and environmental interactions

Researchers at Weill Cornell Medicine and Cornell University's Ithaca campus have developed a new computational method for studying genetic and environmental interactions and how they influence disease risk.

27 Jan 2021

Study uses computational framework to identify tamoxifen resistance markers in ER+ breast cancer

One common challenge of cancer therapy is when cancer cells don't respond to a drug that is usually able to kill or weaken them, known as treatment resistance.

26 Jan 2021

UC research team uses zebrafish to study a gene mutation that causes congenital scoliosis

Popular in aquariums all over the world, the zebrafish is native to South Asia. But here in a Cincinnati Children's laboratory, the freshwater variant plays a vital role in scientific discovery.

22 Jan 2021

Researchers identify genetic risk factors contributing to pneumonia susceptibility and severity

Researchers at Vanderbilt University Medical Center and colleagues have identified genetic factors that increase the risk for developing pneumonia and its severe, life-threatening consequences.

21 Jan 2021

A single genetic test can identify the presence and cause of mismatch repair deficiency

Researchers have developed a new integrated genetic/epigenetic DNA-sequencing protocol known as MultiMMR that can identify the presence and cause of mismatch repair (MMR) deficiency in a single test from a small sample of DNA in colon, endometrial, and other cancers.

21 Jan 2021

Using gene therapy to mimic the effects of physical exercise

It sounds too good to be true - and it is. But Jose Bianco Moreira and the CERG research group at the Norwegian University of Science and Technology are convinced that some of the positive health effects of physical exercise can be achieved using gene therapy and medication.

21 Jan 2021

Antibiotic resistance may be more widespread than previously expected

Pathogenic bacteria in humans are developing resistance to antibiotics much faster than expected. Now, computational research at Chalmers University of Technology, Sweden, shows that one reason could be significant genetic transfer between bacteria in our ecosystems and to humans.

21 Jan 2021

Genomics

Scientists study how different genes dance to the circadian rhythm

New method identifies important mutations behind hereditary non-polyposis colorectal cancer

Researchers release first Japanese reference genome

NEI scientists develop and test a promising gene therapy strategy for rare eye disease

Study uncovers genetic similarities between PTSD and other mental health disorders

Study uncovers rare genetic syndrome caused by mutations in gene SATB1

Genomic studies give new insights into the biological basis of PTSD

Study shows how aneuploidy could become a weak point for cancer cells

Researchers develop new computational method for studying genetic and environmental interactions

Study uses computational framework to identify tamoxifen resistance markers in ER+ breast cancer

UC research team uses zebrafish to study a gene mutation that causes congenital scoliosis

Researchers identify genetic risk factors contributing to pneumonia susceptibility and severity

A single genetic test can identify the presence and cause of mismatch repair deficiency

Using gene therapy to mimic the effects of physical exercise

Antibiotic resistance may be more widespread than previously expected

Researchers discover rare genetic disorder that affects the brain, heart and facial features

Gene editing shows potential to correct mutations causing inherited retinal degeneration

ALS study underscores the unique genetics of Maltese population

Food intake patterns are partly under genetic control, study shows

Study explores how choice of foods influences aging and lifespan in fruit flies

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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