Genomics

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UAB researchers report lack of predictability for fecal microbial transplants without prior antibiotic therapy

A fecal microbial transplant - giving a recipient fecal matter from a donor to change the recipient's gut microbial community in the colon - has been a successful last resort therapy for people with recurrent Clostridium difficile infection after multiple rounds of suppressive antibiotics have eliminated the recipient microbial community.

4 Nov 2022

New evaluation data shows the clinical utility of SOPHiA DDM Dx HRD Solution

SOPHiA GENETICS, a cloud-native software company in the healthcare space, debuted new data at the European Society of Gynaecological Oncology (ESGO) Congress as part of a poster (#PA-065) presented by Prof. Alexandre Harlé of the Institut de Cancérologie de Lorraine, France.

3 Nov 2022

Parental discord linked to children's genetic risk for alcohol problems

Parents can transmit a genetic risk for alcohol problems to their children not only directly, but also indirectly via genetically influenced aspects of the home environment, such as marital discord or divorce, according to a Rutgers researcher.

3 Nov 2022

Whole-genome sequencing is a more comprehensive prenatal test l BGI Perspectives

BGI-Research and the Maternal and Child Health Hospital of Hubei Province (MCHH) published whole-genome sequencing research results in npj Genomic Medicine.

From BGI Genomics 3 Nov 2022

Research reveals how whole-genome sequencing may enhance detection of fetal CNS anomalies

BGI-Research and the Maternal and Child Health Hospital of Hubei Province (MCHH) published whole-genome sequencing research results in npj Genomic Medicine.

3 Nov 2022

New control system could be used to finely tune the production of useful proteins

Using an approach based on CRISPR proteins, MIT researchers have developed a new way to precisely control the amount of a particular protein that is produced in mammalian cells.

1 Nov 2022

Study provides more nuanced insights into RNA modifications by A-to-I editing during brain development

Mount Sinai researchers have cataloged thousands of sites in the brain where RNA is modified throughout the human lifespan in a process known as adenosine-to-inosine (A-to-I) editing, offering important new avenues for understanding the cellular and molecular mechanisms of brain development and how they factor into both health and disease.

1 Nov 2022

Ancient genomes shed light on previously unknown aspect of human evolution

The use of ancient DNA, including samples of human remains around 45,000 years old, has shed light on a previously unknown aspect of human evolution.

31 Oct 2022

Faulty gene may explain why some people gain excessive weight despite normal food intake

A faulty gene, rather than a faulty diet, may explain why some people gain excessive weight even when they don't eat more than others, UT Southwestern researchers at the Center for the Genetics of Host Defense have discovered.

28 Oct 2022

Yeast reveals a key mechanism in how genes are controlled

Yeast, that simple organism essential to making beer and bread, has revealed for Cornell University researchers a key mechanism in how genes are controlled.

28 Oct 2022

New breakthrough in understanding how deletion of certain genes can lead to cancer growth

Genetic mutations kick start cancers. Some mutations shuffle the genetic code, others come from the deletion of key genes.

28 Oct 2022

Proof-of-principle study: Novel tool advances potential way to deliver gene therapy

Johns Hopkins Medicine researchers say they have successfully used a cell's natural process for making proteins to "slide" genetic instructions into a cell and produce critical proteins missing from those cells.

28 Oct 2022

Ancient viral DNA in human genomes protects cells against present-day viruses

Viral DNA in human genomes, embedded there from ancient infections, serve as antivirals that protect human cells against certain present-day viruses, according to new research.

27 Oct 2022

Using stem cell cloning to identify the origin of lethal stomach and esophageal cancers

The University of Houston is leading a team of cancer researchers and experts in stem cell cloning to identify the origin of two very lethal cancers of the stomach and esophagus - esophageal adenocarcinoma (EAC) and intestinal gastric cancer (iGC).

27 Oct 2022

Researchers find a switch to regulate the diabetes-causing gene

Researchers at the Centre for Genomic Regulation and Imperial College London have found a switch that regulates the activity of a gene that causes diabetes.

27 Oct 2022

Large genome-wide association study on nonalcoholic fatty liver disease

Scientists at deCODE genetics in Iceland have discovered rare, protective loss-of-function variants that point to potential drug targets for nonalcoholic fatty liver disease (NAFLD).

24 Oct 2022

Butterfly wing pattern ground plan is manipulated by non-coding regulatory DNA, study says

Butterfly wing patterns have a basic plan to them, which is manipulated by non-coding regulatory DNA to create the diversity of wings seen in different species, according to new research.

21 Oct 2022

Surprising discovery in people of Polynesian ancestry offers clues to genetic underpinnings of high cholesterol

The discovery of a genetic variant that is relatively common among people of Polynesian ancestry, but incredibly rare in most other populations, is giving clues to the genetic underpinnings of high cholesterol in all people, according to new research led by University of Pittsburgh School of Public Health geneticists in partnership with several other groups, including the University of Otago and the Samoan health research community.

21 Oct 2022

Study identifies gene mutations that impact radiation resistance and sensitivity

A new Northwestern Medicine study identifies common and rare gene mutations that impact radiation resistance and sensitivity, an important step toward providing more individualized and effective radiotherapy for patients with cancer.

20 Oct 2022

Scientists pinpoint a large number of genes associated with dyslexia

Scientists have for the first time pinpointed a large number of genes that are reliably associated with dyslexia.

20 Oct 2022

Genomics

UAB researchers report lack of predictability for fecal microbial transplants without prior antibiotic therapy

New evaluation data shows the clinical utility of SOPHiA DDM Dx HRD Solution

Parental discord linked to children's genetic risk for alcohol problems

Whole-genome sequencing is a more comprehensive prenatal test l BGI Perspectives

Research reveals how whole-genome sequencing may enhance detection of fetal CNS anomalies

New control system could be used to finely tune the production of useful proteins

Study provides more nuanced insights into RNA modifications by A-to-I editing during brain development

Ancient genomes shed light on previously unknown aspect of human evolution

Faulty gene may explain why some people gain excessive weight despite normal food intake

Yeast reveals a key mechanism in how genes are controlled

New breakthrough in understanding how deletion of certain genes can lead to cancer growth

Proof-of-principle study: Novel tool advances potential way to deliver gene therapy

Ancient viral DNA in human genomes protects cells against present-day viruses

Using stem cell cloning to identify the origin of lethal stomach and esophageal cancers

Researchers find a switch to regulate the diabetes-causing gene

Large genome-wide association study on nonalcoholic fatty liver disease

Butterfly wing pattern ground plan is manipulated by non-coding regulatory DNA, study says

Surprising discovery in people of Polynesian ancestry offers clues to genetic underpinnings of high cholesterol

Study identifies gene mutations that impact radiation resistance and sensitivity

Scientists pinpoint a large number of genes associated with dyslexia

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting

From street to lab: Advancing controlled substance testing with handheld Raman and FTIR

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