Genomics

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Study finds genetic variants that increase the risk of bedwetting

In a large-scale study of Danish children and young people, researchers from Aarhus University have for the first time found genetic variants that increase the risk of nocturnal enuresis - commonly known as bedwetting or nighttime incontinence.

19 Jan 2021

Compulsory DNA collection is unethical and has a detrimental effect on genetics research

The compulsory collection of DNA being undertaken in some parts of the world is not just unethical, but risks affecting people's willingness to donate biological samples and thus contribute to the advancement of medical knowledge and the development of new treatments, says a paper in the European Journal of Human Genetics, published online* today [18 January 2021].

19 Jan 2021

RECoVERY: New open-source software developed for analyzing SARS-CoV-2 genomes

Researchers report an open-source platform-independent tool for building SARS-CoV-2 genomes from raw sequencing reads. The tool can be used without any extra hardware or software and be run using any browser from a desktop or mobile.

19 Jan 2021

Gene-cutting system may play second role as a genetic dimmer switch

In a series of experiments with laboratory-cultured bacteria, Johns Hopkins scientists have found evidence that there is a second role for the widely used gene-cutting system CRISPR-Cas9 -- as a genetic dimmer switch for CRISPR-Cas9 genes.

19 Jan 2021

Viral genome sequencing of wastewater can be useful for tracking new SARS-CoV-2 variants

Viral genome sequencing of wastewater can detect new SARS-CoV-2 variants before they are detected by local clinical sequencing, according to a new study reported in mBio, an open-access journal of the American Society for Microbiology.

19 Jan 2021

Researchers produce first African lion in-vitro embryos after vitrification of immature oocytes

A team of scientists from the Leibniz Institute for Zoo and Wildlife Research (Leibniz-IZW) inGermany, Givskud Zoo - Zootopia in Denmark and the University of Milan in Italy succeeded in producing the very first African lionin-vitroembryos after the vitrification of immature oocytes.

18 Jan 2021

Computational method uses heat map data to reverse engineer 3D chromosome models

Genome analysis can provide information on genes and their location on a strand of DNA, but such analysis reveals little about their spatial location in relation to one another within chromosomes -- the highly complex, three-dimensional structures that hold genetic information.

15 Jan 2021

Scientists grow insect sex pheromones in transgenic camelina plant for sustainable pest control

The camelina plant, a source of cooking oil for centuries, is on its way toward revolutionizing pest control in agriculture.

15 Jan 2021

Scientists discover genetic variations that have a drastic impact on small molecules

The human organism requires a variety of small molecules, such as sugars or fats, in order to function properly.

14 Jan 2021

New deep-learning framework predicts gene regulation at single-cell level

Scientists at the University of California, Irvine have developed a new deep-learning framework that predicts gene regulation at the single-cell level.

13 Jan 2021

New genomics resource details the small RNA transcriptomes of four mosquito species

Researchers from Boston University School of Medicine provide a new genomics resource that details the small RNA transcriptomes (gene expression) of four bio-medically important mosquito species.

13 Jan 2021

Researchers identify link between ALS and accumulation of DNA-RNA hybrids in the genome

Researchers from the University of Seville and the University of Pavia have identified a link between Amyotrophic Lateral Sclerosis (ALS) and the accumulation of DNA-RNA hybrids in the genome.

13 Jan 2021

Large study provides new understanding of genome diversity in Ukrainian population

Today, the largest study of genetic diversity in Ukraine was published in the open science journal GigaScience.

13 Jan 2021

New taxonomic classification of non-skeletal rare congenital disorders with impact on bone physiology

Thanks to major progress in the understanding and management of rare congenital diseases and syndromes, many patients with these rare disorders are now living longer lives.

13 Jan 2021

Researchers identify a simple way to eliminate sequencing errors produced by portable DNA sequencer

Researchers have found a simple way to eliminate almost all sequencing errors produced by a widely used portable DNA sequencer, potentially enabling scientists working outside the lab to study and track microorganisms like the SARS-CoV-2 virus more efficiently.

13 Jan 2021

Daily circadian cycles may impact our ability to fight disease

An analysis of an exhaustive dataset on cells essential to the mammalian immune system shows that our ability to fight disease may rely more heavily on daily circadian cycles than previously assumed.

12 Jan 2021

Inherited or transmitted gut microbes affect skeletal development in animals

Gut microbes passed from female mice to their offspring, or shared between mice that live together, may influence the animals' bone mass, says a new study published today in eLife.

12 Jan 2021

Study monitors spatial shifts of liver gene expression in relationship to the circadian clock

Nothing in biology is static. Biological processes fluctuate over time, and if we are to put together an accurate picture of cells, tissues, organs etc., we have to take into account their temporal patterns. In fact, this effort has given rise to an entire field of study known as "chronobiology".

11 Jan 2021

Study sheds new light on the role of MLL4 gene in Kabuki syndrome

Scientists have known for years that mutations in the MLL4 gene can cause Kabuki syndrome, a rare developmental disorder.

11 Jan 2021

Master Regulator proteins control cancer transcriptional identity

Thousands of different genetic mutations have been implicated in cancer, but a new analysis of almost 10,000 patients found that regardless of the cancer's origin, tumors could be stratified in only 112 subtypes and that, within each subtype, the Master Regulator proteins that control the cancer's transcriptional state were virtually identical, independent of the specific genetic mutations of each patient.

11 Jan 2021

Genomics

Study finds genetic variants that increase the risk of bedwetting

Compulsory DNA collection is unethical and has a detrimental effect on genetics research

RECoVERY: New open-source software developed for analyzing SARS-CoV-2 genomes

Gene-cutting system may play second role as a genetic dimmer switch

Viral genome sequencing of wastewater can be useful for tracking new SARS-CoV-2 variants

Researchers produce first African lion in-vitro embryos after vitrification of immature oocytes

Computational method uses heat map data to reverse engineer 3D chromosome models

Scientists grow insect sex pheromones in transgenic camelina plant for sustainable pest control

Scientists discover genetic variations that have a drastic impact on small molecules

New deep-learning framework predicts gene regulation at single-cell level

New genomics resource details the small RNA transcriptomes of four mosquito species

Researchers identify link between ALS and accumulation of DNA-RNA hybrids in the genome

Large study provides new understanding of genome diversity in Ukrainian population

New taxonomic classification of non-skeletal rare congenital disorders with impact on bone physiology

Researchers identify a simple way to eliminate sequencing errors produced by portable DNA sequencer

Daily circadian cycles may impact our ability to fight disease

Inherited or transmitted gut microbes affect skeletal development in animals

Study monitors spatial shifts of liver gene expression in relationship to the circadian clock

Study sheds new light on the role of MLL4 gene in Kabuki syndrome

Master Regulator proteins control cancer transcriptional identity

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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