Genomics

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Penn biologists show evidence of a two-sided genomic arms race involving repetitive DNA

Biological arms races are commonplace in nature. Cheetahs, for example, have evolved a sleek body form that lends itself to rapid running, enabling them to feast upon similarly speedy gazelles, the fastest of which may evade predation.

27 May 2022

Understanding transposons provides a new starting point to generate more powerful gene editing tools

CRISPR has ushered in the era of genomic medicine. A line of powerful tools has been developed from the popular CRISPR-Cas9 to cure genetic diseases.

27 May 2022

Exposure of microbial communities to antibiotics could facilitate the spread of plasmid-encoded genes

DNA molecules called plasmids – some of which protect bacteria from antibiotics – can spread rapidly through bacterial "communities" that are treated with antibiotics, new research shows.

27 May 2022

New Spex NanoSNAP™ provides high performance measurements of nucleic acids and proteins in a snap

New Spex NanoSNAP™ provides high performance measurements of nucleic acids and proteins in a snap.

26 May 2022

UCLA researchers discover key molecular mechanism behind memory linking

Our brains rarely record single memories - instead, they store memories into groups so that the recollection of one significant memory triggers the recall of others connected by time.

25 May 2022

Researchers identify the genetic causes of three mitochondrial diseases using new approach

When something goes wrong in mitochondria, the tiny organelles that power cells, it can cause a bewildering variety of symptoms such as poor growth, fatigue and weakness, seizures, developmental and cognitive disabilities, and vision problems.

25 May 2022

Study unveils the novel driver of cardiomyocyte loss

Researchers from the group of Eva van Rooij used advanced sequencing technology to better understand the heart disease arrhythmogenic cardiomyopathy, in which heart muscle tissue is replaced by fat cells. Using explanted human hearts, they found regions in which heart muscle was actively degenerated and identified a new gene, ZBTB11, that drives heart muscle cell degradation. The results were published in Cardiovascular Research on 17 May 2022.

25 May 2022

Study identifies a gene that plays an important role in embryo development

A new study co-led by a Cedars-Sinai investigator identified a gene that plays an important role in a biological pathway involved in embryo development.

24 May 2022

Researchers discover osteogenetic oligodeoxynucleotide that promotes bone differentiation

Bone tissue homeostasis is maintained by a balance between bone formation by osteoblasts and bone resorption by osteoclasts.

23 May 2022

Study sheds light on the molecular biology behind genetic epilepsy

Sometimes, even the alteration of a single nucleotide in a gene can cause serious disease. In a young boy with epilepsy, this kind of mutation has not just affected the functioning of the protein in question – it could also curb the functioning of several closely related proteins.

23 May 2022

Novel genetic test enables earlier, more accurate diagnosis of primary immunodeficiency disorders

Primary immunodeficiency disorders (PID) can result in chronic and sometimes life-threatening infections. More than 450 PIDs have been described, but timely and accurate diagnoses remain a challenge.

23 May 2022

Gene-edited tomatoes could be a simple solution to address vitamin D insufficiency

Tomatoes gene-edited to produce vitamin D, the sunshine vitamin, could be a simple and sustainable innovation to address a global health problem.

23 May 2022

Epistatic drift leads to unpredictability in protein evolution

A critical goal in genetics and evolution is predicting the effects of mutations that may happen in the future and inferring the effects of those that happened in the past.

19 May 2022

Some people weathered the stress of pandemic better than others due to genetics

Everyone has been impacted by the COVID-19 pandemic, but a new study by Lude Franke and colleagues of the University of Groningen, Netherlands finds that some individuals weathered the stress of the pandemic better than others, in part, due to their genetics.

19 May 2022

Genome research explains why oats could be suitable for most people with celiac disease

Ground-breaking new research published in Nature has decoded the genome of oats and explained why the popular cereal could be suitable for most people with coeliac disease and gluten intolerance.

18 May 2022

Researchers show the feasibility of a comprehensive sequencing approach in pediatric and young adult cancers

New findings from researchers at Memorial Sloan Kettering Cancer Center (MSK) and published today in the journal Nature Communications report the results of using a comprehensive sequencing approach on 114 pediatric, adolescent, and young adult patients with solid tumors.

18 May 2022

Exposure to cold and warm temperatures causes changes in gene expression in various organs

Human beings, like most organisms, are constantly exposed to alternating colder or warmer temperatures.

17 May 2022

PerkinElmer expands genomic testing services with ultrarapid whole genome sequencing

PerkinElmer, Inc., a global leader committed to innovating for a healthier world, today announced the availability of ultrarapid whole genome sequencing (urWGS) through PerkinElmer Genomics.

From Revvity 17 May 2022

New drug inhibits growth of the most aggressive meningiomas

When a specific non-metastatic brain tumor — a meningioma — recurs after surgery and radiation treatment, a patient is normally out of options. No drugs are approved for these aggressive tumors, which occur in up to 20 percent of cases and can lead to patient disability or even death.

16 May 2022

Researchers reveal mechanism for spread of antibiotic resistance among bacteria

A bacteria calledStaphylococcusaureusis widespread and generally harmless, but can cause infections known as "opportunistic infections".

13 May 2022

Genomics

Penn biologists show evidence of a two-sided genomic arms race involving repetitive DNA

Understanding transposons provides a new starting point to generate more powerful gene editing tools

Exposure of microbial communities to antibiotics could facilitate the spread of plasmid-encoded genes

New Spex NanoSNAP™ provides high performance measurements of nucleic acids and proteins in a snap

UCLA researchers discover key molecular mechanism behind memory linking

Researchers identify the genetic causes of three mitochondrial diseases using new approach

Study unveils the novel driver of cardiomyocyte loss

Study identifies a gene that plays an important role in embryo development

Researchers discover osteogenetic oligodeoxynucleotide that promotes bone differentiation

Study sheds light on the molecular biology behind genetic epilepsy

Novel genetic test enables earlier, more accurate diagnosis of primary immunodeficiency disorders

Gene-edited tomatoes could be a simple solution to address vitamin D insufficiency

Epistatic drift leads to unpredictability in protein evolution

Some people weathered the stress of pandemic better than others due to genetics

Genome research explains why oats could be suitable for most people with celiac disease

Researchers show the feasibility of a comprehensive sequencing approach in pediatric and young adult cancers

Exposure to cold and warm temperatures causes changes in gene expression in various organs

PerkinElmer expands genomic testing services with ultrarapid whole genome sequencing

New drug inhibits growth of the most aggressive meningiomas

Researchers reveal mechanism for spread of antibiotic resistance among bacteria

Evolving spectrophotometry for modern biopharma workflows

Scaling B-cell cloning workflows for antibody development

Fluidics in Modern Healthcare & Medical Device Innovation

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