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FDA approves monoclonal antibody aducanumab for treating Alzheimer's patients

Today's FDA approval of the monoclonal antibody Aduhelm (aducanumab) to treat patients with Alzheimer's disease reflects years of significant advances in Alzheimer's research. This is the first new Alzheimer's drug approved in 17 years and the first shown to modify the course of the disease, which FDA believes will lead to slowing of patients' cognitive decline.

8 Jun 2021

Drug sensitivity of hepatocellular cancer cells may provide new insights on tumor biology

Oncotarget published "Effect of cell microenvironment on the drug sensitivity of hepatocellular cancer cells" which reported that this study aimed to investigate whether Hepatocellular Cancer (HCC) cells cultured in more native conditions have an altered phenotype and drug sensitivity compared to those cultured in standard conditions.

8 Jun 2021

Lymphangiogenesis predicts favorable outcomes to immunotherapy

Oncotarget published "Mutually exclusive lymphangiogenesis or perineural infiltration in human skin squamous-cell carcinoma" which reported that although tumor-associated lymphangiogenesis correlates with metastasis and poor prognosis in several cancers, it also supports T cell infiltration into the tumor and predicts favorable outcome to immunotherapy.

8 Jun 2021

Study reveals mechanisms by which SGLT2 inhibitors produce renoprotective effect

SGLT2 inhibitors (gliflozins) were developed as oral antidiabetics. They enhance urinary glucose excretion by inhibiting SGLT-2 (sodium-dependent glucose co-transporter-2) in the renal tubuli.

8 Jun 2021

Study offers a deeper understanding of the molecular basis for schizophrenia

A study conducted by a group of Brazilian researchers contributes to a deeper understanding of the molecular basis for schizophrenia, and potentially to the development of more specific and effective treatments for the disease.

8 Jun 2021

Link between SARS-CoV-2 organotropism and kidney injury

It was clear at a relatively early stage of the pandemic that SARS-CoV-2 causes a wide range of symptoms; in addition to typical respiratory symptoms, patients also had neurological symptoms (starting with anosmia), gastrointestinal symptoms, elevated liver values, and renal, urinary or hematological changes, for example.

8 Jun 2021

Study shows how cowpea mosaic plant virus stimulates the immune system against cancer

Previous work by a team of researchers led by Steven N. Fiering, PhD, Immunology and Cancer Immunotherapy researcher at Dartmouth's and Dartmouth-Hitchcock's Norris Cotton Cancer Center and Nicole Steinmetz, PhD, Jacobs School of Engineering and Moores Cancer Center, University of California San Diego, showed that a plant virus that does not infect mammals, cowpea mosaic plant virus (CPMV), when injected into cancerous tumors, strongly stimulated the immune system to attack and often eliminate the tumor.

8 Jun 2021

Researchers develop promising stem cell therapy to treat type 1 diabetes

Type 1 diabetes, which arises when the pancreas doesn't create enough insulin to control levels of glucose in the blood, is a disease that currently has no cure and is difficult for most patients to manage.

8 Jun 2021

Data from pre-adolescent brain activation study may clarify risk factors for mental health disorders

Youth brain activation data from the largest longitudinal neuroimaging study to date provides valuable new information on the cognitive processes and brain systems that underlie adolescent development and might contribute to mental and physical health challenges in adulthood.

8 Jun 2021

New blood test helps monitor patient’s response to cancer treatment

Cancer patients who are undergoing targeted therapy can look forward to a new blood test that could tell their doctors whether the treatment is working, within one day after the start of the treatment.

8 Jun 2021

New drug shows promise against lung cancer caused by genetic mutation

The new drug sotorasib reduces tumor size and shows promise in improving survival among patients with lung tumors caused by a specific DNA mutation, according to results of a global phase 2 clinical trial.

8 Jun 2021

ADHD medications may lower suicide risk in children with hyperactivity, behavioral disorders

ADHD medications may lower suicide risk in children with hyperactivity, oppositional defiance and other behavioral disorders, according to new research from the Lifespan Brain Institute (LiBI) of Children's Hospital of Philadelphia (CHOP) and the University of Pennsylvania.

7 Jun 2021

Addressing climate change for better kidney health

Health has always been affected by climate and weather, but is increasingly clear that the change in climate is a significant threat to human health.

7 Jun 2021

Study reports safety, efficacy of targeted treatment for IgA nephropathy

IgA nephropathy (IgAN) is a chronic kidney disease occurring in young adults and is one of the most common reasons for kidney transplantation in this age group.

7 Jun 2021

Oral antidiabetic medication provides kidney protection in focal segmental glomerulosclerosis

Focal segmental glomerulosclerosis (FSGS) is a rare form of kidney inflammation (glomerulonephritis) in which the glomeruli become increasingly scarred (sclerotic), leading to progressive loss of kidney function.

7 Jun 2021

Ultrasound examinations can be deployed to detect and treat lung congestion in hemodialysis patients

Accumulation of water in the lungs (lungcongestion) is a common condition in hemodialysis patients, particularly in those at high cardiovascular risk, like those presenting coronary artery disease and/or heart failure.

7 Jun 2021

International coalition develops classification criteria for 25 subtypes of uveitis

An international coalition of eye researchers used machine learning to develop classification criteria for 25 of the most common types of uveitis, a collection of over 30 diseases characterized by inflammation inside the eye.

7 Jun 2021

Discovery offers a potential new pathway to treat hypertension

High blood pressure, or hypertension, is the leading modifiable risk factor for cardiovascular diseases and premature death worldwide.

7 Jun 2021

Potential leptin therapy for nonalcoholic steatohepatitis

In those with fatty liver disease, a person's fat goes to their liver instead of their fat tissue, either because of an absence of fat depots, which is seen in the rare genetic disease lipodystrophy, or because the depots are too full, which is seen in people with obesity.

7 Jun 2021

Minimally-invasive procedure could offer hope to patients with high blood pressure

A minimally-invasive procedure that targets the nerves near the kidney has been found to significantly reduce blood pressure in hypertension patients, according to the results of a global multicentre clinical trial led in the UK by researchers at Queen Mary University of London and Barts Health NHS Trust.

7 Jun 2021

Medical Condition News

FDA approves monoclonal antibody aducanumab for treating Alzheimer's patients

Drug sensitivity of hepatocellular cancer cells may provide new insights on tumor biology

Lymphangiogenesis predicts favorable outcomes to immunotherapy

Study reveals mechanisms by which SGLT2 inhibitors produce renoprotective effect

Study offers a deeper understanding of the molecular basis for schizophrenia

Link between SARS-CoV-2 organotropism and kidney injury

Study shows how cowpea mosaic plant virus stimulates the immune system against cancer

Researchers develop promising stem cell therapy to treat type 1 diabetes

Data from pre-adolescent brain activation study may clarify risk factors for mental health disorders

New blood test helps monitor patient’s response to cancer treatment

New drug shows promise against lung cancer caused by genetic mutation

ADHD medications may lower suicide risk in children with hyperactivity, behavioral disorders

Addressing climate change for better kidney health

Study reports safety, efficacy of targeted treatment for IgA nephropathy

Oral antidiabetic medication provides kidney protection in focal segmental glomerulosclerosis

Ultrasound examinations can be deployed to detect and treat lung congestion in hemodialysis patients

International coalition develops classification criteria for 25 subtypes of uveitis

Discovery offers a potential new pathway to treat hypertension

Potential leptin therapy for nonalcoholic steatohepatitis

Minimally-invasive procedure could offer hope to patients with high blood pressure

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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