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Study explores macromolecular viral entry inhibitors as broad-spectrum first-line antivirals with anti-SARS-CoV-2 activities

Researchers created polystyrene sulfonate with significantly different molar masses, constructed these polymers as an exterior around spherical gold nanoparticles of various sizes to improve multivalency effects, measured antiviral effects of the antivirals on numerous viruses in vitro, and investigated the method of interaction of the leads with SARS-CoV-2 and lentiviral particles.

13 May 2022

Antibiotic use could explain the growth in inflammatory bowel disease in older people

The more antibiotics prescribed to patients 60 and older, the more likely they were to develop inflammatory bowel disease, suggesting antibiotic use could explain some of the growth in Crohn's disease and ulcerative colitis in older people, according to a review of 2.3 million patient records in a study selected for presentation at Digestive Disease Week 2022.

13 May 2022

Analysis reveals increasing prevalence of esophageal cancer and Barrett’s esophagus in middle-aged adults

Adults aged 45 to 64 experienced a nearly doubled rate of esophageal cancer and a 50 percent increase in the precancerous condition Barrett's esophagus between 2012 and 2019, according to a database analysis of roughly five million patients to be presented at Digestive Disease Week 2022.

13 May 2022

Gallstones could be a warning sign for aggressive pancreatic cancer

Patients with pancreatic ductal adenocarcinoma (PDAC) were six times more likely to have had gallstone disease within the year prior to diagnosis than non-cancer patients, suggesting gallstones could be a warning sign for this aggressive and deadly cancer, according to research to be presented at Digestive Disease Week (DDW) 2022.

13 May 2022

New poll shows how menopause and other health issues get in the way of older women’s sex lives

Despite stereotypes to the contrary, many older women have active sex lives into their 70s, a new poll shows. But health concerns, including menopause symptoms, often get in the way of intimacy, according to the new results from the University of Michigan National Poll on Healthy Aging.

13 May 2022

A*STAR, NHCS, NUS, and Novo Nordisk partner to study the mechanisms underlying heart failure

The Agency for Science, Technology and Research's Genome Institute of Singapore and Bioinformatics Institute, as well as the National Heart Centre Singapore, National University of Singapore, and pharmaceutical company Novo Nordisk have signed an agreement to study the mechanisms underlying cardiovascular disease progression - especially the condition called heart failure with preserved ejection fraction (HFpEF).

13 May 2022

Hormonal shift during menopause changes women’s blood metabolite profile

In midlife, the risk of cardiometabolic diseases increases in women more rapidly than in men. A study performed at the Faculty of Sport and Health Sciences of the University of Jyväskylä shows that changes in blood metabolite profile accompany the shift in sex hormone levels during menopause.

13 May 2022

Researchers discover new gene that confers resistance to prostate cancer treatment

Northwestern Medicine investigators have identified a gene that confers resistance to a common prostate cancer treatment, according to a study published in Cancer Research.

13 May 2022

Researchers identify compounds from Aspergillus that may be effective against SARS-CoV-2

Researchers from Ain Shams University have been exploring the use of compounds isolated from Aspergillus sp. against SARS-CoV-2.

13 May 2022

Investigating effectiveness of mRNA booster against SARS-CoV-2 Omicron in individuals primed with mRNA or inactivated virus vaccines

Scientists have determined the effectiveness of different vaccination regimens in eliciting humoral immune responses against the SARS-CoV-2 Omicron variant.

13 May 2022

Exploring short-term effectiveness of COVID-19 booster vaccine and stable CD8+ T cell memory after three doses

A new study has longitudinally traced and profiled the CD8+ T cell responses after COVID-19 mRNA booster vaccination.

13 May 2022

Development of a novel surface plasmon resonance-based assay to determine kinetics of SARS-CoV-2 spike – human ACE2 interaction

A team of scientists has recently studied the kinetic and thermodynamic characteristics of interaction between human ACE2 and spike receptor-binding domains of different variants of SARS-CoV-2.

13 May 2022

Study reveals serum proteomic signatures of long COVID patients

In a recent study posted to the bioRxiv*preprint server, researchers evaluated the serum proteomic signatures of long coronavirus disease (COVID) patients.

13 May 2022

SARS-CoV-2 N-terminal domain modulates S1/S2 cleavage and spike-mediated functions

In a recent study posted to the bioRxiv* preprint server, researchers explored the role of the N-terminal domain (NTD) of the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) spike (S) protein in SARS-CoV-2 fusion with the host membranes and coronavirus disease 2019 (COVID-19).

12 May 2022

Dogs can detect SARS-CoV-2 from an individual's sweat

In a recent study published in the Open Forum Infectious Diseases (OFID) Journal, researchers reported that severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) could be detected by canine olfaction.

12 May 2022

New project aims to improve exercise adherence in hemodialysis patients

There are approximately 600,000 individuals in the U.S. who are undergoing hemodialysis (HD) therapy for kidney failure. In hemodialysis, a machine filters wastes, salts, and fluid from the blood when an individual's kidneys are no longer healthy enough to do this work adequately.

12 May 2022

Bayesian viral allele selection for SARS-CoV-2 genomic surveillance

In a recent study posted to the bioRxiv* preprint server, researchers assessed the selection effects in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using Bayesian viral allele selection.

12 May 2022

Topical drugs may regress congenital giant nevi and prevent skin cancer

About one in 20,000 infants is born with what's called a congenital giant nevus - a huge, pigmented mole that may cover much of the face and body.

12 May 2022

Penn study finds low uptake of first mutation-targeted bladder cancer drug

The first bladder cancer drug targeting a cancer-driving gene mutation has been used relatively little despite its clear efficacy in a clinical trial, suggests a study from researchers at the Perelman School of Medicine at the University of Pennsylvania.

12 May 2022

New alcohol consumption patterns during COVID-19 pandemic in the USA

In a recent study published in the journal Alcoholism: Clinical and Experimental Research, researchers evaluated alcohol drinking patterns over 42 weeks post-onset of the coronavirus disease 2019 (COVID-19) pandemic in the United States.

12 May 2022

Medical Research News

Study explores macromolecular viral entry inhibitors as broad-spectrum first-line antivirals with anti-SARS-CoV-2 activities

Antibiotic use could explain the growth in inflammatory bowel disease in older people

Analysis reveals increasing prevalence of esophageal cancer and Barrett’s esophagus in middle-aged adults

Gallstones could be a warning sign for aggressive pancreatic cancer

New poll shows how menopause and other health issues get in the way of older women’s sex lives

A*STAR, NHCS, NUS, and Novo Nordisk partner to study the mechanisms underlying heart failure

Hormonal shift during menopause changes women’s blood metabolite profile

Researchers discover new gene that confers resistance to prostate cancer treatment

Researchers identify compounds from Aspergillus that may be effective against SARS-CoV-2

Investigating effectiveness of mRNA booster against SARS-CoV-2 Omicron in individuals primed with mRNA or inactivated virus vaccines

Exploring short-term effectiveness of COVID-19 booster vaccine and stable CD8+ T cell memory after three doses

Development of a novel surface plasmon resonance-based assay to determine kinetics of SARS-CoV-2 spike – human ACE2 interaction

Study reveals serum proteomic signatures of long COVID patients

SARS-CoV-2 N-terminal domain modulates S1/S2 cleavage and spike-mediated functions

Dogs can detect SARS-CoV-2 from an individual's sweat

New project aims to improve exercise adherence in hemodialysis patients

Bayesian viral allele selection for SARS-CoV-2 genomic surveillance

Topical drugs may regress congenital giant nevi and prevent skin cancer

Penn study finds low uptake of first mutation-targeted bladder cancer drug

New alcohol consumption patterns during COVID-19 pandemic in the USA

Building quality into drug development for safer, faster medicines

How Pulp Fixin Is Turning Paper into High-Performance Sustainable Labware

A new method to measure intracellular water in biological systems

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