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The human antibody response to the SARS-CoV-2 spike protein N-terminal domain in a group of previously infected individuals

Researchers evaluated the human antibody response to the NTD of the S protein by investigating a group of individuals who had previously been infected with SARS-CoV-2 or who had received an mRNA vaccine.

11 Apr 2022

Ultralong bovine antibody targets cryptic and conserved epitope on SARS-CoV and SARS-CoV-2

Researchers identified an ultralong bovine antibody that neutralizes SARS-CoV-2 and SARS-CoV.

11 Apr 2022

Monitoring medication adherence for TB treatment in Africa using AI

Researchers aimed to develop an AI system that can evaluate medication adherence and non-adherence activities of TB patients based on their visual attributes obtained from videos.

11 Apr 2022

Study explores phytochemical-based antivirals against SARS-CoV-2 infection

A new study depicted plant-based biologically active antiviral agents that are effective against SARS-CoV-2 infection.

11 Apr 2022

Study demonstrates multinuclear MRI is sensitive to functional pulmonary changes in the follow up of patients hospitalized with COVID-19

In this study, researchers subjected patients to a pulmonary 1H and 129Xe MRI protocol at 6, 12, 25, and 50 weeks after hospitalization.

11 Apr 2022

Let’s Talk about Parkinson’s

In recognition of World Parkinson's Day, we speak to Dr. Arthur Roach, Director of Research at Parkinson’s UK, about the current Parkinson's landscape.

11 Apr 2022

Study explores COVID-19 vaccine hesitancy among those with underlying medical conditions

In a recent study posted to the medRxiv* preprint server, researchers examined the coronavirus disease 2019 (COVID-19) vaccine uptake and hesitancy among people with chronic or severe health conditions.

11 Apr 2022

New research on SARS-CoV-2 Omicron variant mutations and sotrovimab therapy

A recent study posted to the medRxiv* preprint server assessed the impact of sotrovimab treatment on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant-infected immunocompromised (IC) patients.

11 Apr 2022

Study: Less than half of clinical trials report race/ethnicity data

Clinical trials represent one the largest investments of collective resources in science. These studies, which recruit participants and rigorously evaluate new interventions and therapeutics, aim to advance scientific knowledge and improve patient treatment.

11 Apr 2022

S-Nitrosylation of ACE2 inhibits binding of SARS-CoV-2 spike protein

In a recent study posted to the bioRxiv* preprint server, researchers developed aminoadamantane nitrates compounds that inhibit the ion channels formed by the envelope (E) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and enable targeted drug delivery of nitric oxide (NO)-related group for S-nitrosylation of host angiotensin-converting enzyme 2 (ACE2), which would inhibit ACE2 binding with the viral spike (S) protein and thereby inhibit viral replication in the host.

11 Apr 2022

Impact of cardiovascular disease in pregnant or postpartum COVID-19 patients

In a recent study posted to the medRxiv* preprint server, researchers reported coronavirus disease 2019 (COVID-19) prognosis worsened by the presence of cardiovascular diseases (CVDs) in pregnant and postpartum women.

11 Apr 2022

Immunocompromised hosts with Delta/Omicron co-infections

A recent study posted to the medRxiv* preprint server examined clinical cases of co-infections of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta/Omicron variants and Omicron BA.1/ BA.2 sublineages in immunocompromised (IC) patients.

10 Apr 2022

Challenges, unmet needs and future opportunities in COVID-19 therapeutics

In a recent article published in the journal Proceedings of the National Academy of Sciences (PNAS), researchers reviewed the present-day therapeutic landscape of coronavirus disease 2019 (COVID-19) and addressed future opportunities to overcome challenges that hinder drug development and improve the global preparedness for future pandemics.

10 Apr 2022