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S-Nitrosylation of ACE2 inhibits binding of SARS-CoV-2 spike protein

In a recent study posted to the bioRxiv* preprint server, researchers developed aminoadamantane nitrates compounds that inhibit the ion channels formed by the envelope (E) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and enable targeted drug delivery of nitric oxide (NO)-related group for S-nitrosylation of host angiotensin-converting enzyme 2 (ACE2), which would inhibit ACE2 binding with the viral spike (S) protein and thereby inhibit viral replication in the host.

11 Apr 2022

Impact of cardiovascular disease in pregnant or postpartum COVID-19 patients

In a recent study posted to the medRxiv* preprint server, researchers reported coronavirus disease 2019 (COVID-19) prognosis worsened by the presence of cardiovascular diseases (CVDs) in pregnant and postpartum women.

11 Apr 2022

Immunocompromised hosts with Delta/Omicron co-infections

A recent study posted to the medRxiv* preprint server examined clinical cases of co-infections of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta/Omicron variants and Omicron BA.1/ BA.2 sublineages in immunocompromised (IC) patients.

10 Apr 2022

Challenges, unmet needs and future opportunities in COVID-19 therapeutics

In a recent article published in the journal Proceedings of the National Academy of Sciences (PNAS), researchers reviewed the present-day therapeutic landscape of coronavirus disease 2019 (COVID-19) and addressed future opportunities to overcome challenges that hinder drug development and improve the global preparedness for future pandemics.

10 Apr 2022

The effect of unsuppressed HIV on T-cell response to COVID-19

A new study evaluates the impact of HIV infection on SARS-CoV-2 T-cell responses during the first and second waves of COVID-19 in South Africa.

10 Apr 2022

Oestrogen may be linked to a woman’s risk of developing dementia

A new study examines the risk of dementia with reproductive factors in women.

10 Apr 2022

A novel PLpro inhibitor as a broad-spectrum anti-coronavirus agent

Researchers identify a potentially effective compound against COVID-19 against the SARS-CoV-2 PLpro.

10 Apr 2022

Brain charts show changing morphology by age

A new study develops utilizes neuroimages to understand how the brain grows, develops, and matures with age.

10 Apr 2022

Shared gene expression signatures in type 1 diabetics treated with IL-2 and COVID-19 patients

Researchers assess the impact of interval administration of LD-IL-2 was examined in 18 T1D patients who received a three-day dosing interval.

10 Apr 2022

Machine learning and proteomics predict cardiovascular risk more accurately

An innovative proteomics-based model that predicts the risk of cardiovascular events with higher accuracy than current clinical models.

10 Apr 2022

CDC report on Omicron infections soon after Delta

A new study identifies ten patients with confirmed SARS-CoV-2 Omicron variant infections within 90 days of a previous Delta variant infection.

10 Apr 2022

Study finds better immunotherapy response in lung cancer patients with genetic variant linked to autoimmune disease

A variant of the CTLA-4 gene associated with autoimmune disease was found to be more frequent in non-small cell lung cancer (NSCLC) patients who experienced an exceptionally high response to anti-PD-1 immunotherapy and higher immune-related side effects than in a comparable cohort of lung cancer patients and healthy individuals, according to data presented during the AACR Annual Meeting 2022, held April 8-13.

10 Apr 2022

Common dishwashing detergents may eliminate coronaviruses from glass

Common dishwashing detergents and scrubbing devices found to be sufficient to inactivate and eliminate human coronaviruses from glass surfaces.

10 Apr 2022

Consumption of healthy plant-based foods linked with lower risk of developing type 2 diabetes

New research published in Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]) finds that the consumption of healthy plant-based foods, including fruits, vegetables, nuts, coffee, and legumes, is associated with a lower risk of developing type 2 diabetes (T2D) in generally healthy people and support their role in diabetes prevention.

10 Apr 2022

Researchers provide insight into anatomical position of the sacral mesh during laparoscopic procedure

A May 2022 study published in the Diseases of the Colon and Rectum zooms in on the importance of anatomy. Dr. Argeny and colleagues of the Medical University of Vienna, Austria, provide insight into the anatomical position of the mesh in relation to the sacrum during a laparoscopic procedure.

10 Apr 2022

B-cells have significant differences in women with postpartum depression, finds study

A study published in Molecular Psychiatry is the first to look at multiple levels of biology within women with postpartum depression (PPD) to see how women with the condition differ from those without it.

10 Apr 2022

Study shows benefits of Medicaid expansion for patients diagnosed with de novo stage 4 breast cancer

A new study led by Susan G. Komen® Scholars indicates that patients diagnosed with de novo stage 4 breast cancer – also called metastatic breast cancer– had improved survival rates and decreased mortality rates when those patients had access to care.

10 Apr 2022

Simple interventions reduced radiation exposure to the heart during lung cancer treatment

Radiation to the heart during treatment for locally advanced lung cancer is associated with an increased risk of major adverse cardiac events within the first two years following treatment. The higher the cardiac dose exposure, the higher the risk of a cardiac event.

8 Apr 2022

Cancer risk and related mortality significantly higher among patients with kidney disease

Patients with kidney disease may have an increased risk of cancer and may be more likely to die from cancer.

8 Apr 2022

Imbalances in the intestinal virome may promote inflammatory bowel disease, research shows

Research in recent years has demonstrated the diverse roles that gut bacteria can play in health and disease, but what about contributions from viruses, which, like bacteria, perpetually reside within the human intestine?

8 Apr 2022

Medical Research News

S-Nitrosylation of ACE2 inhibits binding of SARS-CoV-2 spike protein

Impact of cardiovascular disease in pregnant or postpartum COVID-19 patients

Immunocompromised hosts with Delta/Omicron co-infections

Challenges, unmet needs and future opportunities in COVID-19 therapeutics

The effect of unsuppressed HIV on T-cell response to COVID-19

Oestrogen may be linked to a woman’s risk of developing dementia

A novel PLpro inhibitor as a broad-spectrum anti-coronavirus agent

Brain charts show changing morphology by age

Shared gene expression signatures in type 1 diabetics treated with IL-2 and COVID-19 patients

Machine learning and proteomics predict cardiovascular risk more accurately

CDC report on Omicron infections soon after Delta

Study finds better immunotherapy response in lung cancer patients with genetic variant linked to autoimmune disease

Common dishwashing detergents may eliminate coronaviruses from glass

Consumption of healthy plant-based foods linked with lower risk of developing type 2 diabetes

Researchers provide insight into anatomical position of the sacral mesh during laparoscopic procedure

B-cells have significant differences in women with postpartum depression, finds study

Study shows benefits of Medicaid expansion for patients diagnosed with de novo stage 4 breast cancer

Simple interventions reduced radiation exposure to the heart during lung cancer treatment

Cancer risk and related mortality significantly higher among patients with kidney disease

Imbalances in the intestinal virome may promote inflammatory bowel disease, research shows

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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