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Hypertonic saline solution shown to inhibit replication of SARS-CoV-2

Researchers at the University of São Paulo (USP) in Brazil have shown that a hypertonic saline solution inhibits replication of SARS-CoV-2, the virus that causes COVID-19, and have elucidated the biochemical mechanism involved.

22 Sep 2021

COVID-19 vaccination in IBD patients

In this review, researchers reviewed all published research related to Phase 1/2 and/or Phase 3 and 4 studies of SARS-CoV-2 vaccinations.

22 Sep 2021

Many women near the menopause transition use cannabis, study finds

The legalization of cannabis in many areas has led to its use to treat an array of health issues. Of those surveyed in a study out of the University of Alberta, Edmonton, Canada, one in three women near the menopause transition use cannabis;

22 Sep 2021

SARS-CoV-2 genome signature leads to replicative advantage in presence of Remdesivir

A new study indicates that low-level resistance of SARS-CoV-2 to remdesivir is not widespread and dissimilar to other RNA viruses revealing evolutionary predictability of this pandemic virus.

22 Sep 2021

Evidence for safety of Pfizer-BioNTech’s COVID-19 vaccine booster dose

Researchers have conducted a study demonstrating the safety of administering a third (booster) dose of Pfizer-BioNTech’s BNT162b2 vaccine.

22 Sep 2021

SARS-CoV-2 delta variant has higher viral RNA levels and increased infectivity, suggests study

The study found that the delta and epsilon variants exhibited significantly higher infectivity than alpha, with delta containing approximately six times as much infectious virus for the same amount of RNA.

22 Sep 2021

Revised guidelines perpetuate racial and ethnic disparities in lung cancer screening eligibility

Revised guidelines for lung cancer screening eligibility are perpetuating disparities for racial/ethnic minorities, according to a new study in Radiology.

22 Sep 2021

Consumption of common antibiotic during pregnancy can reduce low birth weight and premature births

A common antibiotic has been found to reduce low birth weight and premature births, if taken during pregnancy, in countries where malaria is endemic, according to a research review.

22 Sep 2021

New framework needed to explore links between evolved pathogen tolerance and emerging infections

A new multidisciplinary research framework is needed to explore links between evolved tolerance to pathogens and their spillover into humans, scientists write today in the journal eLife.

22 Sep 2021

Research highlights potentially life-saving screening for HR-HPV–driven head and neck cancers

Cancer causing high-risk human papillomaviruses (HR-HPV) are responsible for the rising incidence of HR-HPV–driven head and neck cancers (HNC), particularly oropharyngeal cancers (OPC, or throat cancers). Investigators have determined that HR-HPV DNA can be detected in saliva in most patients with HPV-driven OPC at the time of diagnosis. This work highlights a potentially life-saving screening program based on salivary HR-HPV DNA testing for early cancer detection and patient monitoring. Their findings appear in The Journal of Molecular Diagnostics, published by Elsevier.

22 Sep 2021

Compound extracted from orchid could be a potential treatment option for prostate cancer

Research led by the Centenary Institute has found that a compound extracted from a commonly cultivated orchid could be a potential new treatment option for prostate cancer.

22 Sep 2021

Study findings could lead to novel ways to overcome tumor resistance to immunotherapies

Cancer-fighting immune cells in patients with lung cancer whose tumors do not respond to immunotherapies appear to be running on a different "program" that makes them less effective than immune cells in patients whose cancers respond to these immune treatments, suggests a new study led by researchers at the Johns Hopkins Kimmel Cancer Center Bloomberg~Kimmel Institute for Cancer Immunotherapy.

22 Sep 2021

Healthy eating pattern improves weight, reduces cardiovascular disease risks in overweight children

A Cleveland Clinic-led research team found that statistically overweight children who followed a healthy eating pattern significantly improved weight and reduced a variety of cardiovascular disease risks.

22 Sep 2021

Children receiving living donor liver transplant less likely to experience organ rejection

In the United States alone, 500 children will need a liver transplant this year. While liver tissue can come from living or deceased donors, no studies have demonstrated which of these methods leads to better outcomes for children. In a new publication, researchers at Children's Hospital Los Angeles pooled published results from over 8,000 pediatric patients across four continents. The data reveal that children who receive living donor liver tissue for transplants are far less likely to experience serious complications like organ rejection.

22 Sep 2021

Study supports the implementation of Beckman Coulter’s MDW in emergency labs as initial test to detect sepsis

Beckman Coulter announced the results of a prospective study carried out across two European hospitals, which found that Monocyte Distribution Width, in combination with White Blood Cell Count with Differential, has the diagnostic accuracy to detect the risk of sepsis and severe infection upon patient presentation in A&E, particularly when assessed in patients with a lower likelihood of sepsis.

22 Sep 2021

Researchers identify distinctive biological markers for earlier detection of pregnancy risks

Researchers from Flinders University and the Robinson Research Institute at the University of Adelaide have identified distinctive biological markers that could improve the routine blood tests pregnant women already undergo and detect risks for pregnancy complications earlier than currently possible.

22 Sep 2021

Research pinpoints new therapeutic opportunity for ovarian clear cell carcinomas

Mutations in the ARID1A gene are present in more than 50% of ovarian clear cell carcinomas (OCCC), for which effective treatments are lacking. Scientists at The Wistar Institute discovered that loss of ARID1A function enhances a cellular stress response pathway that promotes survival of cancer cells, which become sensitive to pharmacological inhibition of this pathway. These findings were published online in Cancer Research, a journal of the American Association for Cancer Research, and point to a new therapeutic opportunity for this type of ovarian cancer for which new solutions are urgently needed.

22 Sep 2021

Researchers explore which types of brain activity support consciousness

Consciousness remains one of the brain's biggest mysteries. We know very little about how it emerges from activity within the brain, but most neuroscientists agree consciousness is dynamic in nature.

22 Sep 2021

Researchers devise guidelines for reporting mediation analyses of trials, observational studies

A new guideline has been developed to help scientists publish their research accurately and transparently. Published in JAMA, the AGReMA Statement (A Guideline for Reporting Mediation Analyses) provides recommendations for researchers who want to describe mediation analysis in their paper. Mediation analysis is primarily used to understand how an intervention works or why it does not.

22 Sep 2021

Young people with cancer face inequalities in fertility preservation services across the UK

Young people who survive cancer are at risk of missing out on the chance to have children in the future, due to inequalities in fertility preservation services across the UK, new research has found.

22 Sep 2021

Medical Research News

Hypertonic saline solution shown to inhibit replication of SARS-CoV-2

COVID-19 vaccination in IBD patients

Many women near the menopause transition use cannabis, study finds

SARS-CoV-2 genome signature leads to replicative advantage in presence of Remdesivir

Evidence for safety of Pfizer-BioNTech’s COVID-19 vaccine booster dose

SARS-CoV-2 delta variant has higher viral RNA levels and increased infectivity, suggests study

Revised guidelines perpetuate racial and ethnic disparities in lung cancer screening eligibility

Consumption of common antibiotic during pregnancy can reduce low birth weight and premature births

New framework needed to explore links between evolved pathogen tolerance and emerging infections

Research highlights potentially life-saving screening for HR-HPV–driven head and neck cancers

Compound extracted from orchid could be a potential treatment option for prostate cancer

Study findings could lead to novel ways to overcome tumor resistance to immunotherapies

Healthy eating pattern improves weight, reduces cardiovascular disease risks in overweight children

Children receiving living donor liver transplant less likely to experience organ rejection

Study supports the implementation of Beckman Coulter’s MDW in emergency labs as initial test to detect sepsis

Researchers identify distinctive biological markers for earlier detection of pregnancy risks

Research pinpoints new therapeutic opportunity for ovarian clear cell carcinomas

Researchers explore which types of brain activity support consciousness

Researchers devise guidelines for reporting mediation analyses of trials, observational studies

Young people with cancer face inequalities in fertility preservation services across the UK

Advancing Drug Safety Assessment With AI, Predictive Modeling, and Human-Relevant Data

AI-powered analytics and experimental validation

Membrane proteins in focus: Turning high-risk targets into routine workflows

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