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Efficacy of polymeric nano-micelles depends on expression level of c-Myc

The Innovation Center of NanoMedicine (Director General: Prof. Kazunori Kataoka, Location: Kawasaki in Japan, Abbreviation: iCONM) reported in ACS Nano (Impact Factor: 14.588 in 2019) together with the group of Prof. Yu Matsumoto of Otorhinolaryngology and Head and Neck Surgery (Prof. Tatsuya Yamasoba) and the group of Prof. Horacio Cabral of the Department of Bioengineering (Prof. Ryo Miyake) in the University of Tokyo that the efficacy of polymeric nano-micelles with different drug activation profile depends on the expression level of c-Myc, one of the major proto-oncogene, has been developed.

27 Feb 2021

MicroRNAs predict heart and kidney health in children without disease

Molecules called microRNAs (miRNAs) that are measurable in urine have been identified by researchers at Mount Sinai as predictors of both heart and kidney health in children without disease.

27 Feb 2021

Researchers use new approaches to address premature failure of dental restorations

How can dental restorations - such as fillings and crowns - be made to last longer? A new research group centered at Charité - Universitätsmedizin Berlin and Technische Universität (TU) Berlin plans to address this topic by utilizing approaches from both materials science and dentistry.

27 Feb 2021

Newly identified genes increase risk of obesity and also protect against this disease

People living with obesity tend to have unhealthy glucose and lipid levels in their blood, as well as high blood pressure.

27 Feb 2021

Study on artificial microswimmers could improve the efficacy of targeted cancer therapy

A Mason Engineering researcher has discovered that artificial microswimmers accumulate where their speed is minimized, an idea that could have implications for improving the efficacy of targeted cancer therapy.

27 Feb 2021

Diverse patient population helps identify gene variant associated with childhood asthma

Researchers at Henry Ford Health System, as part of a national asthma collaborative, have identified a gene variant associated with childhood asthma that underscores the importance of including diverse patient populations in research studies.

27 Feb 2021

Study demonstrates the novel agonistic effect of curcumin on lipid transcription

Curcumin is a polyphenol compound produced by plants of the Curcuma longa species and has been reported to have many physiological activities, which include anti-oxidation, anti-inflammatory, anti-cancer, and anti-amyloid properties.

27 Feb 2021

Atherosclerosis can speed up the development of clonal hematopoiesis

Billions of peripheral white blood cells are produced every day by the regular divisions of hematopoietic stem cells and their descendants in the bone marrow.

27 Feb 2021

Specific preparatory neural mechanism can lead to improved motor performance

A number of brain areas change their activity before we execute a planned voluntary movement. A new study by Umeå University identifies a novel function of this preparatory neural activity, highlighting another mechanism the nervous system can use to achieve its goals.

27 Feb 2021

Study: Heart problems cause disturbed gene activity in the brain's memory center

Heart problems cause disturbed gene activity in the brain's memory center, from which cognitive deficits arise.

27 Feb 2021

Biomarkers in the blood can predict severe outcomes in COVID-19 patients

When patients with COVID-19 arrive in emergency rooms, there are relatively few ways for doctors to predict which ones are more likely to become critically ill and require intensive care and which ones are more likely to enjoy a quick recovery.

26 Feb 2021

Researchers develop an electroceutical for preterm labor detection and treatment

Preterm labor comprises 12.7% of all pregnancies. Although the overall rate of pregnancy is decreasing, the occurrence of premature birth due to preterm labor in south korea has been increasing over the past 7 years.

26 Feb 2021

UNH receives $2.97 million in grants to investigate the effectiveness of wilderness therapy

The University of New Hampshire's Outdoor Behavioral Healthcare Center receives $2.97 million in grants to conduct a first-of-its-kind randomized study looking at the effectiveness of outdoor behavioral health (OBH), or wilderness therapy, a prescriptive treatment for teens struggling with depression, anxiety and substance use disorders.

26 Feb 2021

Statin use associated with reduction in mortality of patients with severe COVID-19

People who took statins to lower cholesterol were approximately 50% less likely to die if hospitalized for COVID-19, a study by physicians at Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian has found.

26 Feb 2021

New seizure predicting mathematical model gives accurate warning to epilepsy patients

Epilepsy is one of the most common neurological conditions, affecting more than 65 million worldwide. For those dealing with epilepsy, the advent of a seizure can feel like a ticking time bomb.

26 Feb 2021

Early PDA closure may reduce adverse outcomes in premature babies

Extremely low birth weight (ELBW) infants with moderate to large patent ductus arteriosus (PDA) may benefit from transcatheter PDA closure (TCPC) in the first four weeks of life, according to research published by Le Bonheur Cardiologist Ranjit Philip, MD, and Medical Director of Interventional Cardiac Imaging and Interventional Catheterization Laboratory Shyam Sathanandam, MD.

26 Feb 2021

Study finds novel way to diagnose Alzheimer's disease before symptoms occur

Early diagnosis of Alzheimer's disease has been shown to reduce cost and improve patient outcomes, but current diagnostic approaches can be invasive and costly.

26 Feb 2021

NLRP3 inflammasome inhibitors may help treat early COVID-19, says study

A new study by researchers in the U.S. further supports the hypothesis that the unregulated release of inflammatory cytokines is responsible for the local and systemic inflammation that is associated with multi-organ damage and death in severe COVID-19.

26 Feb 2021

South African SARS-CoV-2 variant partly resistant to neutralization by mRNA vaccine, says study

A new study deals with the clinical and virological effects of circulating SARS-CoV-2 variants, especially as they affect vaccine efficacy.

26 Feb 2021

Repurposed drugs show antiviral SARS-CoV-2 E channel blocking activity, finds study

A new study by researchers at The Hebrew University of Jerusalem in Israel reports the discovery of a promising group of E channel inhibitors with significant antiviral activity. This could be developed into new treatment agents for this often-deadly virus.

26 Feb 2021

Medical Research News

Efficacy of polymeric nano-micelles depends on expression level of c-Myc

MicroRNAs predict heart and kidney health in children without disease

Researchers use new approaches to address premature failure of dental restorations

Newly identified genes increase risk of obesity and also protect against this disease

Study on artificial microswimmers could improve the efficacy of targeted cancer therapy

Diverse patient population helps identify gene variant associated with childhood asthma

Study demonstrates the novel agonistic effect of curcumin on lipid transcription

Atherosclerosis can speed up the development of clonal hematopoiesis

Specific preparatory neural mechanism can lead to improved motor performance

Study: Heart problems cause disturbed gene activity in the brain's memory center

Biomarkers in the blood can predict severe outcomes in COVID-19 patients

Researchers develop an electroceutical for preterm labor detection and treatment

UNH receives $2.97 million in grants to investigate the effectiveness of wilderness therapy

Statin use associated with reduction in mortality of patients with severe COVID-19

New seizure predicting mathematical model gives accurate warning to epilepsy patients

Early PDA closure may reduce adverse outcomes in premature babies

Study finds novel way to diagnose Alzheimer's disease before symptoms occur

NLRP3 inflammasome inhibitors may help treat early COVID-19, says study

South African SARS-CoV-2 variant partly resistant to neutralization by mRNA vaccine, says study

Repurposed drugs show antiviral SARS-CoV-2 E channel blocking activity, finds study

Advancing Menopause Care: Non-Hormonal Treatments for Vasomotor Symptoms

Building quality into drug development for safer, faster medicines

How Pulp Fixin Is Turning Paper into High-Performance Sustainable Labware

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