Gene News and Research

Latest Gene News and Research

MicroRNA biomarker shows promise in predicting treatment response of ovarian cancer

Researchers at Case Western Reserve University have identified a microRNA biomarker that shows promise in predicting treatment response in the most common form of ovarian cancer - a breakthrough that has the potential to improve outcomes for patients with the disease.

9 Jan 2014

NYSCF and ISMMS scientists successfully generate stem cell model of familial Alzheimer's disease

Scientists at The New York Stem Cell Foundation Research Institute in collaboration with scientists at the Icahn School of Medicine at Mount Sinai successfully generated a stem cell model of familial Alzheimer's disease.

8 Jan 2014

Nociceptin in brain naturally moderates effects of stress

Collaborating scientists at The Scripps Research Institute (TSRI), the National Institutes of Health (NIH) and the University of Camerino in Italy have published new findings on a system in the brain that naturally moderates the effects of stress.

8 Jan 2014

Study compares relative rate of molecular evolution between humans and chimps with their lice

A new study compares the relative rate of molecular evolution between humans and chimps with that of their lice. The researchers wanted to know whether evolution marches on at a steady pace in all creatures or if subtle changes in genes - substitutions of individual letters of the genetic code - occur more rapidly in some groups than in others.

8 Jan 2014

Study raises hopes for new drugs to treat brain disorders associated with neurotransmitter imbalance

Although drugs have been developed that inhibit the imbalance of neurotransmitters in the brain - a condition which causes many brain disorders and nervous system diseases - the exact understanding of the mechanism by which these drugs work has not yet been fully understood.

8 Jan 2014

NeoGenomics launches new test for detection of mutations in CALR gene

NeoGenomics, Inc., a leading provider of cancer-focused genetic testing services, announced today that it has validated and launched a new test for the detection of mutations in the calreticulin (CALR) gene. The CALR gene is a novel biomarker that was reported to be specific for myeloproliferative neoplasms (MPN) for the first time at the annual meeting of the American Society of Hematology last month.

8 Jan 2014

Sanford Health gifts $125M to establish Imagenetics program that integrates genomic medicine into primary care for adults

Sanford Health announced today Denny Sanford, the preeminent health care philanthropist in the United States, will gift the organization $125 million to establish Sanford Imagenetics, a first-of-its-kind program in the country that integrates genomic medicine into primary care for adults.

8 Jan 2014

Study reveals epigenetic changes also play a role in breast cancer risk

Breast cancer runs in families; however, genetic predisposition (such as being BRCA1 or BRCA2 mutation carriers) explains only a portion of this observation.

8 Jan 2014

Insight Genetics receives $1.5M SBIR contract to research on resistance mutations in NSCLC patients

Insight Genetics, Inc. today announced it has received a new $1.5 million Phase II Small Business Innovation Research contract from the National Cancer Institute.

8 Jan 2014

Study links racism-related factors and biological aging among African American men

A new study reveals that racism may impact aging at the cellular level. Researchers found signs of accelerated aging in African American men, ages reporting high levels of racial discrimination and who had internalized anti-Black attitudes.

8 Jan 2014

Scientists believe that new links between brain cells help encode new memories and skills

In adults, some brain regions retain a "childlike" ability to establish new connections, potentially contributing to our ability to learn new skills and form new memories as we age, according to new research from Washington University School of Medicine in St. Louis and the Allen Institute for Brain Science in Seattle.

8 Jan 2014

AP-1 proteins modulate fat accumulation in liver, say researchers

Excessive alcohol consumption, as well as obesity leads to the accumulation of fat in the liver, a disease termed fatty liver disease (FLD) or steatosis. FLD is one of the most prevalent diseases in Western societies and affects about 30% of the adult population. Importantly, FLD increases the risk of liver failure, diabetes and cancer and no pharmacological therapies exist for this detrimental disease.

8 Jan 2014

Research reveals two new genetic causes of neonatal diabetes

Research by the University of Exeter Medical School has revealed two new genetic causes of neonatal diabetes.

8 Jan 2014

Study sheds light on the biological underpinnings of obesity

A new neuroscience study sheds light on the biological underpinnings of obesity. The in vivo study, published in the January 8 issue of the Journal of Neuroscience, reveals how a protein in the brain helps regulate food intake and body weight. The findings reveal a potential new avenue for the treatment of obesity and may help explain why medications that are prescribed for epilepsy and other conditions that interfere with this protein, such as gabapentin and pregabalin, can cause weight gain.

7 Jan 2014

Hotspots of fuel consumption in adult brain also show key characteristics of developing brain

Although brain growth slows as individuals age, some regions of the brain continue to develop for longer than others, creating new connections and remodeling existing circuitry.

7 Jan 2014

EC grants approval for ABRAXANE in combination with gemcitabine for metastatic pancreatic cancer

Celgene International Sàrl, a wholly-owned subsidiary of Celgene Corporation, today announced that the European Commission has granted approval for ABRAXANE (paclitaxel formulated as albumin bound nanoparticles, or nab-paclitaxel) in combination with gemcitabine for first-line treatment of adult patients with metastatic adenocarcinoma of the pancreas, or metastatic pancreatic cancer.

7 Jan 2014

Horizon, AstraZeneca partner to explore oncology-relevant genotypes to identify novel drug targets

Horizon Discovery and AstraZeneca have entered into a research, collaboration and license agreement to explore a range of oncology-relevant genotypes with the aim of identifying and validating a number of novel drug targets. This deal is the second collaboration between AstraZeneca and Horizon, and follows the announcement in April 2013 of an oncology discovery program to explore Horizon's first-in-class kinase target program, HD-001.

7 Jan 2014

Epizyme achieves POC milestone in EPZ-5676 DOT1L inhibitor clinical program

Epizyme, Inc., a clinical stage biopharmaceutical company creating innovative personalized therapeutics for patients with genetically defined cancers, today announced the achievement of the proof of concept milestone in the EPZ-5676 DOT1L inhibitor clinical program, earning a $25 million payment under the company's collaboration with Celgene Corporation.

7 Jan 2014

Study suggests new target for drugs to treat head and neck tumors

The increased activation of a key oncogene in head and neck cancers could be the result of mutation and dysfunction of regulatory proteins that are supposed to keep the gene, which has the potential to cause cancer, in check, according to a new study led by researchers at the University of Pittsburgh School of Medicine.

7 Jan 2014

Viewpoints: Rethinking what health insurance should cover; Sen. Johnson suing over congressional health plan; Medicaid's unsung success

The proper role of health insurance should be to finance necessary and expensive medical services without the patient incurring devastating financial consequences. Over the last decade, however, Americans have come to expect their health insurance to subsidize the consumption of all medical care. ... This shift in expectation has meant that health insurance stands out as entirely different from all other types of insurance. Ask yourself: Would you use automobile insurance to buy gasoline? Would you use homeowner insurance to finance painting your house? This wrongheaded view has played an important role in contributing to rapidly rising health care costs (George P. Shultz, Scott W. Atlas and John F. Cogan, 1/5).

7 Jan 2014

Gene News and Research

Latest Gene News and Research

MicroRNA biomarker shows promise in predicting treatment response of ovarian cancer

NYSCF and ISMMS scientists successfully generate stem cell model of familial Alzheimer's disease

Nociceptin in brain naturally moderates effects of stress

Study compares relative rate of molecular evolution between humans and chimps with their lice

Study raises hopes for new drugs to treat brain disorders associated with neurotransmitter imbalance

NeoGenomics launches new test for detection of mutations in CALR gene

Sanford Health gifts $125M to establish Imagenetics program that integrates genomic medicine into primary care for adults

Study reveals epigenetic changes also play a role in breast cancer risk

Insight Genetics receives $1.5M SBIR contract to research on resistance mutations in NSCLC patients

Study links racism-related factors and biological aging among African American men

Scientists believe that new links between brain cells help encode new memories and skills

AP-1 proteins modulate fat accumulation in liver, say researchers

Research reveals two new genetic causes of neonatal diabetes

Study sheds light on the biological underpinnings of obesity

Hotspots of fuel consumption in adult brain also show key characteristics of developing brain

EC grants approval for ABRAXANE in combination with gemcitabine for metastatic pancreatic cancer

Horizon, AstraZeneca partner to explore oncology-relevant genotypes to identify novel drug targets

Epizyme achieves POC milestone in EPZ-5676 DOT1L inhibitor clinical program

Study suggests new target for drugs to treat head and neck tumors

Viewpoints: Rethinking what health insurance should cover; Sen. Johnson suing over congressional health plan; Medicaid's unsung success

eBook: Using iPSCs models for human disease research and drug discovery eBook

Todd Bauman and Chris Povich

Scaling organ‑chip technology for human‑relevant drug discovery

Unlocking drug amorphization: Continuous, solvent-free twin screw granulation