Gene News and Research

Latest Gene News and Research

Link between IL-8, MIF gene polymorphisms and progression of atrophic gastritis and intestinal metaplasia

Atrophic gastritis and intestinal metaplasia are two important precursory lesions in the process of intestinal type gastric cancer. However, the precise mechanism of the progression of these two lesions is still unclear, a few studies have investigated the risk of host gene polymorphism on the atrophic gastritis and intestinal metaplasia, but all of them are limited by their one-time point screen.

13 Apr 2010

Results of research study on the expression of KIF6 in mouse model

Celera Corporation and its collaborators at The University of Washington, WA, and Indiana University, IN, today announced the presentation of data from a research study that investigated the expression of KIF6 in a mouse Celera Corporation model. A key finding was that KIF6 was specifically expressed in macrophages and chondrocytes in mouse atherosclerotic lesions, but not in normal arteries.

12 Apr 2010

Study of changes in transcription factor binding can help understand evolution of gene regulation

As published today in Science, researchers from Cambridge, Glasgow and Greece have discovered a remarkable amount of plasticity in how transcription factors, the proteins that bind to DNA to control the activation of genes, maintain their function over large evolutionary distances.

12 Apr 2010

Gene playing crucial role in immune system balance identified

A team led by St. Jude researchers identified a gene pivotal for immune system balance. Ultimately, the discovery may aid efforts to tame allergies and asthma.

12 Apr 2010

Accumulation of mutated protein may explain damaging cellular behavior in Huntington's disease

In a step towards a possible treatment for Huntington's disease, scientists at Albert Einstein College of Medicine of Yeshiva University have shown for the first time that the accumulation of a mutated protein may explain damaging cellular behavior in Huntington's disease. Their research is described in the April 11 online edition of Nature Neuroscience.

12 Apr 2010

Research shows association between LRP16 expression in colorectal cancer and disease related death

Leukemia related protein 16 gene is an important estrogen-responsive gene. LRP16 gene plays an important role in the carcinogenesis and progression of hormone-dependent cancer. LRP16 expression was also reported to be associated with invasion, metastasis and prognosis of gastric carcinoma. But no comprehensive description of LRP16 protein expression in colorectal cancer has been reported.

12 Apr 2010

Terrible tragedy for Alzheimer's suffering mother and family

In an bizarre situation a 31 year old Australian woman called Rebecca Doig, who gave birth to a healthy girl last week does not even remember giving birth to the child. The little girl called Emily has never been taken into her mother’s arms and it seems never will.

12 Apr 2010

Latest advancement in the development of lab tests for bipolar disorder

Genetic testing may rise to a new level with the findings of Indiana University School of Medicine researchers whose "prototype" for laboratory testing for bipolar disorder appears today in the online edition of the American Journal of Medical Genetics Part B: Neuropsychiatric Genetics.

9 Apr 2010

Gelatinase B expression enhanced in gastric cancer compared to normal gastric mucosa

Gastric cancer in Mexico is the most frequent gastrointestinal malignant neoplasm. Several precursor conditions, such as chronic gastritis, have been associated with the development of gastric cancer. The gelatinases MMP-2 and MMP-9, members of the metalloproteinase family, are fundamental enzymes in extracellular matrix remodelling. The extracellular matrix is composed of secreted molecules outside cells which provides structural support and regulates cell behaviour.

9 Apr 2010

New methodology helps investigate unfolding of DNA

NYU Langone Medical Center researchers have developed a powerful new method to investigate the discrete steps necessary to turn on individual genes and examine how the process goes wrong in cancer and other diseases. The finding, based on seven years of research and described in the April 9 issue of Molecular Cell, allows scientists to investigate the unfolding of DNA, a process required for gene activation.

9 Apr 2010

World's largest autism science and advocacy organization awards 16 new research grants

Autism Speaks, the world's largest autism science and advocacy organization, today announced the awarding of 16 new research grants totaling $5,223,743 over the next three years.

9 Apr 2010

Five-year, $3.7M trial evaluates customized warfarin dosage based on patient genetics

A five-year, $3.7 million clinical trial will investigate how to balance the benefits and risks of warfarin, a drug that helps prevent potentially deadly blood clots.

9 Apr 2010

UBC doctoral candidate discovers a mechanism for silencing retroviruses

A University of British Columbia doctoral candidate has discovered a previously unknown mechanism for silencing retroviruses, segments of genetic material that can lead to fatal mutations in a cell's DNA.

8 Apr 2010

Smoking may increase risk of MS in people who have established risk factors for MS

A new study shows that smoking may increase the risk of multiple sclerosis in people who also have specific established risk factors for MS. The research is found in the April 7, 2010, online issue of Neurology, the medical journal of the American Academy of Neurology.

8 Apr 2010

Researchers identify major indicator of heart failure and aortic aneurysms

Case Western Reserve University School of Medicine researchers have identified a major indicator of two deadly diseases of the heart and blood vessels: heart failure and aortic aneurysm. The absence of the Kruppel-like Factor 15, when combined with stress, leads to both heart failure and aortic aneurysms.

8 Apr 2010

USPTO allows Alnylam Pharmaceuticals' new claims from Woppmann et al. patent series

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today that the United States Patent Office (USPTO) has allowed a patent (Application No. 10/560,336) for the Woppmann et al. patent series, entitled "Double-stranded ribonucleic acid with increased effectiveness in an organism." The newly allowed patent includes 31 claims broadly covering compositions and methods, including pharmaceutical compositions, for small interfering RNAs (siRNAs), the molecules that mediate RNAi.

8 Apr 2010

UNC Charlotte researcher improves lives of families and children affected by birth defects

Birth defects remain a leading cause of death in the first year of life. According to the March of Dimes, every 3 to 4 minutes a baby is born with a birth defect in the United States. About 1 in every 33 infants is affected by birth defects.

8 Apr 2010

Researchers find new genomic approach to identify smokers at risk of lung cancer

Researchers from Boston University School of Medicine in collaboration with investigators at the University of Utah, have discovered a new approach for identifying smokers at the highest risk for developing lung cancer. The findings, which appear in the April 7th issue of Science Translational Medicine, will allow the researchers to use a genomic approach to prevent lung cancer in these individuals and to personalize cancer chemoprophylaxis and therapy.

8 Apr 2010

Phase II clinical trial of Avastin and Tarceva in patients with glioblastoma multiforme

Patients suffering from recently diagnosed malignant brain tumors called glioblastoma multiforme or a rare variant called gliosarcoma may be eligible to participate in a Phase II clinical trial at Cedars-Sinai Medical Center that combines two innovative drugs.

8 Apr 2010

EndoChoice announces acquisition of Pathworks Anatomic Pathology Laboratory

EndoChoice, Inc. announced today that it has acquired Pathworks Anatomic Pathology Laboratory. Founded in 1989, Pathworks is a College of American Pathologists (CAP) accredited national reference laboratory located in Atlanta, GA. Robert Smith, MD, founder of the laboratory, will assume the Medical Director position of EndoChoice Pathology, a wholly-owned subsidiary of EndoChoice, Inc.

8 Apr 2010

Gene News and Research

Latest Gene News and Research

Link between IL-8, MIF gene polymorphisms and progression of atrophic gastritis and intestinal metaplasia

Results of research study on the expression of KIF6 in mouse model

Study of changes in transcription factor binding can help understand evolution of gene regulation

Gene playing crucial role in immune system balance identified

Accumulation of mutated protein may explain damaging cellular behavior in Huntington's disease

Research shows association between LRP16 expression in colorectal cancer and disease related death

Terrible tragedy for Alzheimer's suffering mother and family

Latest advancement in the development of lab tests for bipolar disorder

Gelatinase B expression enhanced in gastric cancer compared to normal gastric mucosa

New methodology helps investigate unfolding of DNA

World's largest autism science and advocacy organization awards 16 new research grants

Five-year, $3.7M trial evaluates customized warfarin dosage based on patient genetics

UBC doctoral candidate discovers a mechanism for silencing retroviruses

Smoking may increase risk of MS in people who have established risk factors for MS

Researchers identify major indicator of heart failure and aortic aneurysms

USPTO allows Alnylam Pharmaceuticals' new claims from Woppmann et al. patent series

UNC Charlotte researcher improves lives of families and children affected by birth defects

Researchers find new genomic approach to identify smokers at risk of lung cancer

Phase II clinical trial of Avastin and Tarceva in patients with glioblastoma multiforme

EndoChoice announces acquisition of Pathworks Anatomic Pathology Laboratory

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut