Gene News and Research

Latest Gene News and Research

Striking difference identified between mRNA vaccination vs. SARS-CoV-2 infection immune responses

A team of scientists from the United States has recently compared the immune response elicited by natural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) vaccination. Their findings reveal that, unlike vaccination, natural SARS-CoV-2 infection is associated with a robust interferon response together with an induction of cytotoxic gene expression in peripheral blood lymphocytes. The study is currently available on the medRxiv* preprint server.

22 Apr 2021

Researchers discover molecule that provides dual protection against vascular inflammation

A multidisciplinary team of researchers from Duke-NUS Medical School and the Agency for Science, Technology and Research (A*STAR) in Singapore discovered a new mitochondrial peptide called MOCCI that plays an important role in regulating inflammation of blood vessel and immunity.

22 Apr 2021

Interleukin 11-producing fibroblasts can be potential therapeutic targets for treating colorectal cancer

IL-11 is known to promote the development of colorectal cancer in humans and mice, but when and where IL-11 is expressed during cancer development is unknown.

22 Apr 2021

Mutations in estrogen receptor gene associated with worse outcomes after breast cancer treatment

A small proportion of women who receive anti-estrogen treatment after breast cancer surgery have worse outcomes. This is associated with mutations in the estrogen receptor gene, according to a study from Lund University now published in JNCI Cancer Spectrum.

22 Apr 2021

RNA secondary structures can contribute strongly to gene regulation, research shows

A team of scientists from Russia studied the role of double-stranded fragments of the maturing RNA and showed that the interaction between distant parts of the RNA can regulate gene expression. The research was published in Nature Communications.

22 Apr 2021

Gene-regulatory mechanisms at an early embryonic stage govern the flowering behavior of Arabidopsis

Researchers at GMI - Gregor Mendel Institute of Molecular Plant Biology of the Austrian Academy of Sciences - and the John Innes Centre, Norwich, United Kingdom, determine that gene-regulatory mechanisms at an early embryonic stage govern the flowering behavior of Arabidopsis later in development. The paper is published in the journal PNAS.

22 Apr 2021

SARS-CoV-2 vaccine with single-cycle adenovirus vector

Researchers in the United States have developed adenovirus vectors that may be more effective at generating immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) than those used in the vaccines that are currently being rolled out to help combat the coronavirus disease 2019 (COVID-19) pandemic.

21 Apr 2021

Collaborative research could expedite or eliminate the need to manually adjust bioproduction process

Much of common pharmaceutical development today is the product of laborious cycles of tweaking and optimization.

21 Apr 2021

Novel approach to gene editing bypasses disease-causing mutations in a gene

A new approach to gene editing using the CRISPR/Cas9 system bypasses disease-causing mutations in a gene, enabling treatment of genetic diseases linked to a single gene, such as cystic fibrosis, certain types of sickle cell anemia, and other rare diseases.

21 Apr 2021

Interfering RNA nanoparticles could be a potential COVID-19 therapy

Study shows lipid nanoparticle-based siRNA is potent in suppressing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the causative agent of coronavirus disease 2019 (COVID-19) – in cells as well as in mice models.

21 Apr 2021

Researchers explore cost-effective identification method for novel SARS-CoV-2 variants

In a new study, a rapid and cost-effective method of detecting known variants of concern has been developed utilizing capillary electrophoresis, allowing local facilities to screen for and track SARS-CoV-2 variants of concern and implement reactionary procedures.

21 Apr 2021

New efforts to improve the efficacy of nucleotide-based drugs against prostate cancer, bone metastasis

Published in the Advanced Functional Materials, University of Minnesota researcher Hongbo Pang led a cross-institutional study on improving the efficacy of nucleotide-based drugs against prostate cancer and bone metastasis.

21 Apr 2021

Field of mathematics reveals a potential gene that causes acute lymphoblastic leukemia

Using a widely known field of mathematics designed mainly to study how digital and other forms of information are measured, stored and shared, scientists at Johns Hopkins Medicine and Johns Hopkins Kimmel Cancer Center say they have uncovered a likely key genetic culprit in the development of acute lymphoblastic leukemia (ALL).

21 Apr 2021

Characterization of lab-produced neutralizing antibodies targeting SARS-CoV-2

A new study led by Hans-Martin Jäck of the Friedrich-Alexander University Erlangen-Nuremberg in Germany engineered clusters of neutralizing monoclonal antibodies using a transgenic mouse model. A unique characteristic for the antibodies was the different ways it bound to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the overall reduction in the viral spread for human ACE2.

21 Apr 2021

Researchers identify the cause of severe canine juvenile epilepsy

In a study conducted at the University of Helsinki, researchers found a cause for severe epilepsy resulting in death in Parson Russell Terrier puppies at a few months of age. A change in the PITRM1 gene can lead to a dysfunction of mitochondria, the cellular energy pumps.

21 Apr 2021

Study challenges the assumption that all South African Bantu speakers are a single genetic entity

Almost 80% of South Africans speak one of the SEB family languages as their first language. Their origins can be traced to farmers of West-Central Africa whose descendants over the past two millennia spread south of the equator and finally into Southern Africa.

20 Apr 2021

Gene News and Research

Latest Gene News and Research

Striking difference identified between mRNA vaccination vs. SARS-CoV-2 infection immune responses

Researchers discover molecule that provides dual protection against vascular inflammation

Interleukin 11-producing fibroblasts can be potential therapeutic targets for treating colorectal cancer

Mutations in estrogen receptor gene associated with worse outcomes after breast cancer treatment

RNA secondary structures can contribute strongly to gene regulation, research shows

Gene-regulatory mechanisms at an early embryonic stage govern the flowering behavior of Arabidopsis

SARS-CoV-2 vaccine with single-cycle adenovirus vector

Collaborative research could expedite or eliminate the need to manually adjust bioproduction process

Novel approach to gene editing bypasses disease-causing mutations in a gene

Interfering RNA nanoparticles could be a potential COVID-19 therapy

Researchers explore cost-effective identification method for novel SARS-CoV-2 variants

New efforts to improve the efficacy of nucleotide-based drugs against prostate cancer, bone metastasis

Field of mathematics reveals a potential gene that causes acute lymphoblastic leukemia

Characterization of lab-produced neutralizing antibodies targeting SARS-CoV-2

Researchers identify the cause of severe canine juvenile epilepsy

Study challenges the assumption that all South African Bantu speakers are a single genetic entity

Genethon announces dosing of first patient at pediatric clinical trial platform for neuromuscular diseases

Comprehensive roadmap of muscle aging reveals potential targets for treatments

Targeted therapy may be of great benefit in early stage breast cancer

Researchers develop new biomaterial that regrows blood vessels and bone

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging