Telomere News and Research

Latest Telomere News and Research

Omega-3 fatty acid supplements could slow key biological process linked to aging

Taking enough omega-3 fatty acid supplements to change the balance of oils in the diet could slow a key biological process linked to aging, new research suggests.

2 Oct 2012

Increase in rates of short telomeres predicts longevity in mammals

A team of researchers from the Spanish National Cancer Research Centre (CNIO), headed by CNIO Director Mar-a Blasco, has demonstrated in a pioneering study on mammals that longevity is defined at a molecular level by the length of telomeres. The work-which is published today in the online edition of the journal Cell Reports-opens the door to further study of these cellular components in order to calculate the rate at which cells age and thus be able to determine life expectancy for a particular organism.

28 Sep 2012

Lonafarnib proves effective for children with progeria

Results of the first-ever clinical drug trial for children with Progeria, a rare, fatal "rapid-aging" disease, demonstrate the efficacy of a farnesyltransferase inhibitor (FTI), a drug originally developed to treat cancer. The clinical trial results, completed only six years after scientists identified the cause of Progeria, included significant improvements in weight gain, bone structure and, most importantly, the cardiovascular system, according to The Progeria Research Foundation (PRF) and Boston Children's Hospital.

25 Sep 2012

Study discovers pathways that govern instability of GAA/TTC repeats

A study of more than 6,000 genes in a common species of yeast has identified the pathways that govern the instability of GAA/TTC repeats. In humans, the expansions of these repeats is known to inactivate a gene - FXN - which leads to Friedreich's ataxia, a neurodegenerative disease that is currently incurable. In yeast, long repeats also destabilize the genome, manifested by the breakage of chromosomes.

11 Sep 2012

CNIO team generates transgenic mouse model for aplastic anaemia associated with short telomeres

Aplastic anaemia is characterised by a reduction in the number of the bone marrow cells that go on to form the different cell types present in blood (essentially red blood cells, white blood cells and platelets). In most cases, the causes of the disorder are hard to determine, but some patients have been found to have genetic alterations leading to a shortening of their telomeres (the end regions of chromosomes that protect and stabilise DNA).

30 Aug 2012

Children of older fathers inherit longer telomeres

If your father and grandfather waited until they were older before reproducing, you might experience life-extending benefits. Biologists assume that a slow pace of aging requires that the body invest more resources in repairing cells and tissues.

12 Jun 2012

Researchers identify new functions of cohesin SA1 that are relevant for cancer and CdLS

Cohesin is a ring-shaped protein complex involved in the spatial organization of the genome and in mitotic chromosome structure. Vertebrate somatic cells have two versions of cohesin that contain either SA1 or SA2, but their functional specificity has been largely ignored. Researchers of the Spanish National Cancer Research Centre (CNIO) under the direction of Ana Losada have identified new functions of cohesin SA1 that are relevant for two human diseases, cancer and Cornelia de Lange Syndrome.

4 May 2012

Kids who are abused or bullied may age faster

The study finds that violence-related stress in children affects telomeres - special DNA sequences found at the tips of chromosomes. Telomeres, which prevent DNA from unravelling, get shorter each time cells divide, which limits the number of times cells can divide. Shorter telomeres have been linked to poorer survival and chronic diseases. Previous research has shown that smoking, obesity, mental-health disorders and stress may accelerate the process of telomere loss. This suggests that telomere length may reflect a person's biological age as well as their chronological age.

25 Apr 2012

Stress can shorten telomeres at a very young age

Children who have experienced violence might really be older than their years. The DNA of 10-year-olds who experienced violence in their young lives has been found to show wear and tear normally associated with aging, a Duke University study has found.

24 Apr 2012

Hepatitis B-infected patients with longer telomeres more likely to develop HCC

Hepatitis B-infected patients with significantly longer telomeres—the caps on the end of chromosomes that protect our genetic data— were found to have an increased risk of getting liver cancer compared to those with shorter ones, according to findings presented by researchers at Jefferson's Kimmel Cancer Center at the American Association for Cancer Research (AACR) Annual Meeting 2012.

4 Apr 2012

Starvation during childhood may increase risk of heart complications

Russians born during the Leningrad Siege in World War II, which was responsible for some of the greatest losses of civilian life in history, are giving scientists new strategies to identify people who experienced intrauterine growth restriction (IUGR) and starvation during childhood at greatest risk of developing long term heart complications.

31 Mar 2012

Strong link between telomere shortening and heart disease risk

No one really wants the short end of the stick, in this case the short end of a chromosome. Telomeres, which are DNA-protein complexes at the ends of chromosomes, can be thought of as protein "caps" that protect chromosomes from deteriorating and fusing with neighboring chromosomes.

26 Mar 2012

tAI could predict sensitivity to chemotherapy in patients with triple-negative breast cancer

Scientists have uncovered a marker of DNA damage that could predict who will respond to platinum-based chemotherapy drugs like cisplatin or carboplatin.

23 Mar 2012

Scientists create worm model of back-up telomere repair strategy

Rapidly dividing cancer cells are skilled at patching up damage that would stop normal cells in their tracks, including wear and tear of telomeres, the protective caps at the end of each chromosome.

22 Mar 2012

Meditation improves ability to cope with stress and increases telomerase activity

Calmly meditating produces exciting, beneficial effects on your body. It can protect your DNA against cancer-promoting genetic developments and free you from everyday stresses and distractions. That's why meditation is one of the most powerful, but often neglected, tools for maintaining optimal health.

21 Mar 2012

Life Length, Cenegenics Carolinas partner to offer telomere testing

Representatives from Cenegenics Carolinas, the Southeast's leading age management practice, today announced that the practice is now offering cutting-edge telomere length testing to provide an accurate prediction of biological age and risk for disease.

17 Mar 2012

Researchers identify first gene mutation associated with chronic, often fatal form of neuroblastoma

Researchers have identified the first gene mutation associated with a chronic and often fatal form of neuroblastoma that typically strikes adolescents and young adults. The finding provides the first clue about the genetic basis of the long-recognized but poorly understood link between treatment outcome and age at diagnosis.

14 Mar 2012

Yoga can improve cognitive functioning and reduce depression in dementia caregivers

For every individual who's a victim of Alzheimer's - some 5.4 million persons in the United States alone - there's a related victim: the caregiver. Spouse, son, daughter, other relative or friend, the loneliness, exhaustion, fear and most of all stress and depression takes a toll.

14 Mar 2012

Salk scientists' discovery explains how a class of chemotherapy drugs works

The well-being of living cells requires specialized squads of proteins that maintain order. Degraders chew up worn-out proteins, recyclers wrap up damaged organelles, and-most importantly-DNA repair crews restitch anything that resembles a broken chromosome. If repair is impossible, the crew foreman calls in executioners to annihilate a cell. As unsavory as this last bunch sounds, failure to summon them is one aspect of what makes a cancer cell a cancer cell.

12 Mar 2012

Flat worms may hold key to immortality

Experts from Nottingham University created a colony of more than 20,000 flatworms from one original by chopping it into pieces and observing each section grow into a new complete worm. They believe that it could help scientists develop new methods to allow humans to stay younger for longer.

1 Mar 2012

Telomere News and Research

Latest Telomere News and Research

Omega-3 fatty acid supplements could slow key biological process linked to aging

Increase in rates of short telomeres predicts longevity in mammals

Lonafarnib proves effective for children with progeria

Study discovers pathways that govern instability of GAA/TTC repeats

CNIO team generates transgenic mouse model for aplastic anaemia associated with short telomeres

Children of older fathers inherit longer telomeres

Researchers identify new functions of cohesin SA1 that are relevant for cancer and CdLS

Kids who are abused or bullied may age faster

Stress can shorten telomeres at a very young age

Hepatitis B-infected patients with longer telomeres more likely to develop HCC

Starvation during childhood may increase risk of heart complications

Strong link between telomere shortening and heart disease risk

tAI could predict sensitivity to chemotherapy in patients with triple-negative breast cancer

Scientists create worm model of back-up telomere repair strategy

Meditation improves ability to cope with stress and increases telomerase activity

Life Length, Cenegenics Carolinas partner to offer telomere testing

Researchers identify first gene mutation associated with chronic, often fatal form of neuroblastoma

Yoga can improve cognitive functioning and reduce depression in dementia caregivers

Salk scientists' discovery explains how a class of chemotherapy drugs works

Flat worms may hold key to immortality

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