erythromycin (as ethyl succinate)
CONSUMER MEDICINE INFORMATION
What is in this leaflet
This leaflet answers some common questions about E-Mycin tablets and mixtures.
It does not contain all the available information. It does not take the place of talking
to your doctor or pharmacist.
All medicines have benefits and risks. Your doctor has weighed the risks of you taking
E-Mycin against the benefits expected for you.
If you have any concerns about taking this medicine, talk to your doctor or pharmacist.
Keep this leaflet with your medicine.
You may need to read it again.
What E-Mycin is used for
E-Mycin is used to:
treat certain bacterial infections
control acne, in addition to other acne treatments
prevent infections in people with a history of rheumatic disease, congenital heart
disease or other acquired valvular heart disease and who are allergic to penicillin
E-Mycin is an antibiotic that belongs to a group of medicines called macrolides. These
medicines work by killing or stopping the growth of bacteria, which cause infections
or make acne worse.
E-Mycin will not work against infections caused by viruses, such as colds or flu.
Ask your doctor if you have any questions about why E-Mycin has been prescribed for
Your doctor may have prescribed E-Mycin for another reason.
E-Mycin is available only with a doctor's prescription.
There is no evidence that E-Mycin is addictive.
Before you take E-Mycin
When you must not take it
Do not take E-Mycin if you are allergic to:
medicines containing erythromycin (e.g. EES) or any other antibiotic from the macrolide
group (e.g. clarithromycin, roxithromycin)
any of the ingredients listed at the end of this leaflet.
Some of the symptoms of an allergic reaction may include:
Skin rash, itching or hives;
Swelling of the face, lips, tongue or other parts of the body;
Shortness of breath, wheezing or troubled breathing.
Do not take E-Mycin if you are taking any of the following medicines:
terfenadine or astemizole
cisapride, pimozide or domperidone
class IA and III antiarrhythmics e.g. quinidine, disopyramide, procainamide, amiodarone
certain neuroleptics and tri- and tetracyclic antidepressants
arsenic trioxide, methadone, budipine, certain fluoroquinolones, imidazole anti-mycotics
and anti-malarials e.g. petamidine i.v.
simvastatin, lovastatin or atorvastatin
ergotamine or dihydroergotamine
Taking E-Mycin with any of the above medicines may cause serious side effects.
Ask your doctor or pharmacist if you are not sure if you are taking one of the above
Do not take E-Mycin if you have:
severe liver disease
heart rhythm disorders from birth of have developed it
irregular heartbeat or severe chronic heart failure
deficiency of potassium and magnesium in blood
Do not take E-Mycin if the packaging shows signs of tampering or the tablets or mixtures
do not look quite right.
Do not take E-Mycin if the expiry date (EXP) printed on the label has passed.
If you take this medicine after the expiry date, it may not work as well.
Do not use any E-Mycin mixture left in the bottle after 10 days.
If you are not sure whether you should start taking E-Mycin, talk to your doctor.
Before you start to take it
Tell your doctor if you are allergic to any other medicines, foods, dyes or preservatives.
Tell your doctor if you are pregnant or plan to become pregnant.
Your doctor will discuss the risks and benefits of taking E-Mycin during pregnancy.
Tell your doctor if you are breastfeeding or wish to breastfeed.
Your doctor will discuss the risks and benefits of taking E-Mycin when breastfeeding.
Tell your doctor if you have any medical conditions including:
myasthenia gravis, a condition in which the muscles become weak and tire easily
If you have not told your doctor about any of the above, tell them before you start
Taking other medicines
Tell your doctor or pharmacist if you are taking any other medicines, including medicines
you can buy without a prescription from a pharmacy, supermarket or health food shop.
Some medicines may interfere with EES. These include:
medicines used to prevent blood clotting, such as warfarin, acenocoumarol
some medicines used for epilepsy such as phenytoin, carbamazepine, hexobarbital, phenobarbital
(phenobarbitone) and valproate
theophylline, a medicine used to treat asthma
diltiazem, verapamil, felodipine and mibefradil, medicines used to treat high blood
pressure and certain heart conditions
digoxin, a medicine used to treat heart failure
omeprazole and cimetidine, used to prevent ulcers by reducing amount of acid produced
ciclosporin, used to prevent organ transplant rejection or to treat certain problems
with the immune system
tacrolimus, used as an adjunct to kidney transplantation
triazolam, zopiclone and midazolam, used to treat sleeplessness
nefazodone and St. John's wort, medicines used to treat depression
alprazolam used to treat anxiety disorders
methylprednisolone, a corticosteroid
vinblastine, a medicine used to treat Hodgkin's Disease
sildenafil, used to treat erectile dysfunction in adult males
mizolastine and ebastine medicines used to treat allergies such as hay fever
ritonavir, used to treat infections in patients with advanced HIV infection
medicines used to treat fungal infections such as ketoconazole, itraconazole, fluconazole
rifabutin, rifampicin, clindamycin, lincomycin, chloramphenicol, streptomycin, colistin
and bactericidal betalactam antibiotics (e.g. penicillin, cephalosporin)
bromocriptine, used to treat various conditions including Parkinson's Disease
colchicine, used for pain relief in gout
alfentanil, a medicine used for pain relief during anaesthesia
cilostazol, a medicine used in the treatment of painful calves, due to poor blood
flow to the muscles
diphenoxylate with atropine used to treat diarrhoea
opiates used as analgesics.
Your doctor can tell you what to do if you are taking any of these medicines. You
may need different amounts of yours medicines, or you may need to take different medicines.
If you are not sure whether you are taking any of these medicines, check with your
doctor or pharmacist.
Your doctor and pharmacist have more information on medicines to be careful with or
avoid while taking E-Mycin.
How to take E-Mycin
Follow all directions given to you by your doctor and pharmacist carefully.
They may differ from the information contained in this leaflet.
If you do not understand the instructions on the bottle, ask your doctor or pharmacist
How much to take
The usual adult dose is one E-Mycin tablet (400 mg) every six hours but this may vary
from person to person.
Your doctor will tell you how many tablets you will need to take. This depends on
the infection being treated and how severe it is.
For children, their doctor will work out the dose according to their age, body weight
and how severe the infection is.
Your doctor will adjust the amount or frequency of your doses according to the infection
being treated and the severity of the condition.
How to take it
Tablets: Swallow whole with a glass of water.
Mixture: Always shake the bottle well before using a metric measure to measure the
Shaking the bottle and using a medicine measure will make sure that you get the correct
dose. You can buy a medicine measure from your pharmacist.
When to take it
Space the doses of E-Mycin evenly apart and take them at about the same time each
This will allow E-Mycin to have its best effect and also help you to remember when
to take it.
E-Mycin can be taken with or without food. However, taking E-Mycin with food may help
reduce the chance of a stomach upset occurring.
How long to take it for
Keep taking E-Mycin until you finish the tablets or mixture, or for as long as your
If you are being treated for an infection, E-Mycin is usually taken for one to two
weeks. Your infection may not clear completely if you stop taking your medicine too
For controlling acne, E-Mycin is normally taken for a few months.
Check with your doctor if you are not sure how long you should be taking E-Mycin.
If you forget to take it
If it is almost time for your next dose, skip the dose you missed and take your next
dose when you are meant to.
Otherwise, take the missed dose as soon as you remember, and then go back to taking
your medicine as you would normally.
Do not take a double dose to make up for the dose you missed.
If you have any questions or are not sure what to do, ask your doctor or pharmacist.
If you take too much (overdose)
Immediately telephone your doctor, or the Poisons Information Centre (telephone 13
11 26), or go to Accident and Emergency at the nearest hospital, if you think you
or anyone else may have taken too much E-Mycin.
Do this even if there are no signs of discomfort or poisoning.
You may need urgent medical attention.
If you take too much E-Mycin, you may have nausea, vomiting or problems with your
While you are taking E-Mycin
Things you must do
If you are taking E-Mycin for an infection and your symptoms do not improve within
a few days, or if they become worse, tell your doctor.
If your baby develops irritability with feeding or has severe vomiting during treatment
with E-Mycin, tell your doctor immediately. This may be a sign of a stomach disorder
in the infant.
If you are about to be started on any new medicine, remind your doctor and pharmacist
that you are taking E-Mycin.
Tell any other doctors, dentists, and pharmacists who treat you that you are taking
If you are going to have surgery, tell the surgeon or anaesthetist that you are being
given this medicine.
It may affect other medicines used during surgery.
If you become pregnant while taking E-Mycin, tell your doctor.
If you get severe diarrhoea, tell your doctor or pharmacist immediately. Do this even
if it occurs several weeks after you have stopped taking E-Mycin.
Do not take any diarrhoea medicine without checking with your doctor.
Diarrhoea may mean that you have a serious condition affecting your bowel. You may
need urgent medical care.
If you have to have any urine tests, tell your doctor you are taking E-Mycin.
E-Mycin may affect the results of some tests.
If you develop itching with swelling or skin rash or difficulty breathing while you
are taking E-Mycin, do not take any more and contact your doctor immediately.
If you get a sore, white mouth or tongue while taking or soon after stopping E-Mycin,
tell your doctor. Also tell your doctor if you get vaginal itching or discharge.
This may mean you have a fungal infection called thrush. Sometimes, the use of E-Mycin
allows fungi to grow and the above symptoms to occur. E-Mycin does not work against
Things you must not do
Do not use E-Mycin to treat any other conditions unless your doctor tells you to.
Do not give E-Mycin to anyone else, even if they have the same condition as you.
Do not stop taking E-Mycin, even if you feel better after a few days, unless advised
by your doctor.
If you stop taking E-Mycin too soon, the infection may not clear completely or your
symptoms may return.
If possible, your doctor will gradually reduce the amount you take each day before
stopping the medicine completely.
Tell your doctor or pharmacist as soon as possible if you do not feel well while you
are taking E-Mycin.
E-Mycin treats infections and controls acne in most people, but it may have unwanted
side effects in some people.
All medicines can have side effects. Sometimes they are serious, most of the time
they are not. You may need medical treatment if you get some of the side effects.
Ask your doctor or pharmacist to answer any questions you may have.
Do not be alarmed by this list of possible side effects.
You may not experience any of them.
If any of the following happen, stop taking E-Mycin and tell your doctor immediately
or go to Accident and Emergency at the nearest hospital:
signs of an allergic reaction such as any type of skin rash, itching, or hives; swelling
of the face, lips, tongue or other parts of the body; shortness of breath, wheezing,
watery and severe diarrhoea, which may also be bloody.
The above list includes very serious side effects. You may need urgent medical attention
Tell your doctor immediately or go to Accident and Emergency at the nearest hospital
if you notice any of the following:
yellowing of the eyes or skin (jaundice)
severe stomach cramps
feeling generally unwell and having poor appetite
loss of hearing
ringing or buzzing in the ears
fast, irregular or pounding heart beat, palpitations
muscle pain, weakness and joint swelling
dizziness, drowsiness, confusion, hallucinations, fits
any type of skin rash, itching, hives, serious scaly red rash with bumps under skin
severe diarrhoea especially if bloody
any vision problems.
in infants, irritability with feeding or severe vomiting.
The above list includes serious side effects which may require medical attention.
Tell your doctor if you notice any of the following and they worry you:
stomach cramps and pains
feeling sick, vomiting, accumulation of gas and severe diarrhoea
oral thrush (white, furry sore tongue and mouth)
vaginal thrush (sore and itchy vagina, vaginal discharge).
The above list includes the more common and mild side effects of E-Mycin.
Tell your doctor if you notice anything that is making you feel unwell.
Other side effects not listed above may also occur in some people.
After you have finished taking E-Mycin
Tell your doctor immediately if you notice any of the following side effects, particularly
if they occur several weeks after stopping treatment with E-Mycin:
severe abdominal cramps or stomach cramps
watery and severe diarrhoea, which may also be bloody
fever, in combination with one or both of the above.
You may have a serious condition affecting your bowel. These are rare but serious
side effects. Therefore, you may need urgent medical attention.
Do not take any medicine for diarrhoea without first checking with your doctor.
After taking E-Mycin
Keep E-Mycin where children cannot reach it.
A locked cupboard at least one-and-a-half metres above the ground is a good place
to store medicines.
Keep E-Mycin tablets in a cool, dry place where the temperature stays below 30°C.
Keep E-Mycin mixture in the refrigerator but not in the freezer.
Do not use any mixture left in the bottle after 10 days.
Do not store E-Mycin or any other medicine in the bathroom or near a sink.
Do not leave E-Mycin in the car or on window sills.
Heat and dampness can destroy some medicines.
If your doctor tells you to stop taking E-Mycin, or your medicine has passed its expiry
date, ask your pharmacist what to do with any that is left over.
What it looks like
E-Mycin is available as a tablet and mixture.
Tablets are flesh pink in colour, oval-shaped, film-coated and marked "E-N" on one
side and a Greek alpha symbol on the other. Each pack contains 25 tablets.
Mixtures are available as two strengths:
Both mixtures are pink, cherry flavoured and sugar-free. Each bottle contains 100
mL of mixture.
The active ingredient in E-Mycin tablets and mixtures is erythromycin (as erythromycin
E-Mycin tablets contain 400 mg of erythromycin (as erythromycin ethyl succinate).
The E-Mycin tablets also contain the following inactive ingredients:
calcium hydrogen phosphate anhydrous
sodium starch glycollate
Opadry Pink OY-B-34901 (contains colours titanium dioxide CI 77891), iron oxide
red CI 77491 ).
E-Mycin tablets do not contain lactose, sucrose, gluten, tartrazine or any other azo
E-Mycin 200 - each 5 mL contains 200 mg of erythromycin (as erythromycin ethyl succinate).
E-Mycin 400 - each 5 mL contains 400 mg of erythromycin (as erythromycin ethyl succinate).
The mixtures also contain the following inactive ingredients:
propylene glycol alginate
colloidal anhydrous silica
sodium benzoate (211)
erythrosine CI45430 (127)
Trusil Nature Identical Cherry Flavour (contains preservative 320).
E-mycin 200 contains benzoates, aspartame and sorbitol (12.5 g in 40 mL)
E-mycin 400 contains benzoates, aspartame and sorbitol (5.1 g in 20 mL).
Products containing sorbitol may have a laxative effect or cause diarrhoea.
Phenylketonurics are warned that this product contains phenylalanine.
E-Mycin mixtures do not contain lactose, sucrose, gluten, tartrazine or any other
E-Mycin is made in Australia by:
Alphapharm Pty Ltd
Level 1, 30 The Bond
30-34 Hickson Road
Millers Point NSW 2000
Australian Registration Numbers:
E-Mycin - AUST R 71310
E-Mycin 200 - AUST R 48286
E-Mycin 400 - AUST R 48287
This leaflet was prepared in April 2021.