Consumer Medicine Information
What is in this leaflet
This leaflet answers some common questions about Sandostatin.
The information in this leaflet was last updated on the date listed on the final page.
More recent information on the medicine may be available.
You should ensure that you speak to your pharmacist or doctor to obtain the most up
to date information on the medicine. You can also download the most up to date leaflet
Those updates may contain important information about the medicine and its use of
which you should be aware.
It does not contain all the available information. It does not take the place of talking
to your doctor or pharmacist.
All medicines have risks and benefits. Your doctor has weighed the risks of you using
Sandostatin against the benefits they expect it will have for you.
If you have any concerns about using this medicine, ask your doctor or pharmacist.
Keep this leaflet with the medicine.
You may need to read it again.
What Sandostatin is used for
Sandostatin has three uses:
1. Sandostatin is used to treat acromegaly
In people with acromegaly the body makes too much growth hormone, which controls the
growth of tissues, organs and bones. This leads to enlargement of the bones, especially
of the hands and feet. Other symptoms include headaches, increased sweating, tiredness,
numbness of the hands and feet, pain and stiffness in the joints and loss of sexual
function. By blocking the excess growth hormone, Sandostatin can relieve many of these
2. Sandostatin is used to relieve symptoms of certain types of cancer such as carcinoid
syndrome and VIPoma.
By blocking hormones that are over-produced in these conditions, Sandostatin can relieve
symptoms such as flushing of the skin and severe diarrhoea.
3. Sandostatin is used for people who are having surgery on the pancreas. This medicine
helps to lower the chance of complications after the surgery.
Sandostatin contains octreotide, a man-made medicine derived from somatostatin, a
substance found in the human body. Octreotide is used instead of somatostatin because
its effects are stronger and last longer so that it needs to be given only 2 or 3
times a day.
Ask your doctor if you have any questions about why Sandostatin has been prescribed
Your doctor may have prescribed this medicine for another reason.
This medicine is only available with a doctor's prescription. It is not addictive.
There is very little information on the use of this medicine in children.
Before you use Sandostatin
When you must not use it
Do not use Sandostatin if you have an allergy to:
octreotide (the active ingredient in Sandostatin) or any of the other ingredients
listed at the end of this leaflet.
Some of the symptoms of an allergic reaction may include shortness of breath, wheezing
or difficulty breathing; swelling of the face, lips, tongue or other parts of the
body; rash, itching or hives on the skin.
Do not use Sandostatin after the expiry date printed on the pack or if the packaging
is torn or shows signs of tampering.
In that case, return it to your pharmacist.
Before you start to use it
Tell your doctor if you have, or have had, any of the following medical conditions:
gallstones currently or in the past
diabetes, as Sandostatin can affect blood sugar levels. If you are diabetic, your
sugar levels should be checked regularly
problems with your liver
a history of vitamin B12 deprivation.
Your doctor may want to take special precautions if you have any of the above conditions.
Tell your doctor if you are taking other medicines to control blood pressure (beta-blockers
or calcium channel blockers) or agents to control fluid and electrolyte balance.
Dose adjustment may be necessary.
Tell your doctor if you are pregnant or intend to become pregnant or wish to breast-feed
There is not much information on the use of Sandostatin during pregnancy or breast-feeding.
If it is necessary for you to use this medicine, your doctor will discuss with you
the benefits and risks involved. They may recommend that you use a method of contraception
to prevent pregnancy during your treatment. It is not known if Sandostatin passes
into breast milk. Breastfeeding is not recommended during treatment with Sandostatin.
If you have not told your doctor about any of these things, tell him/her before you
Taking other medicines
Tell your doctor if you are taking any other medicines, including any that you buy
without a prescription from a pharmacy, supermarket or health food shop.
Some medicines and Sandostatin may interfere with each other. Some of these medicines
bromocriptine, a medicine which is also used to treat acromegaly
medicines for diabetes
cimetidine, a medicine for ulcers
cyclosporin, a medicine used to suppress the immune system
quinidine, a medicine used to prevent irregular heartbeats
medicines to control blood pressure (beta-blockers or calcium channel blockers)
agents to control fluid and electrolyte balance
You may need to take different amounts of your medicines or you may need to take different
Your doctor and pharmacist have more information on medicines to be careful with or
avoid while using Sandostatin.
How to use Sandostatin
Follow all directions given to you by your doctor and pharmacist carefully.
These directions may differ from the information contained in this leaflet.
If you do not understand the instructions on the label, ask your doctor or pharmacist
How it is given
Sandostatin cannot be taken by mouth because it is rapidly broken down in the stomach.
Instead it is given as a subcutaneous injection. That means that it is injected into
the fat layer just under the skin.
How much is given
The dose of Sandostatin depends on the condition being treated.
1. Acromegaly: treatment is usually started with injections of 0.05 to 0.1 mg every 8
or 12 hours. The dose can then be adjusted depending on how well it blocks growth
hormone and relieves symptoms such as tiredness, sweating and headache.
2. Carcinoid syndrome and VIPoma: treatment is usually started with injections of 0.05
mg once or twice a day. The dose can be increased if symptoms such as diarrhoea are
3. Surgery on the pancreas: injections of 0.1 mg are usually given three times a day
for one week, starting about an hour before the operation.
If you are giving the injections yourself
If you will be giving the injections yourself, your doctor or nurse will teach you
how to do it properly.
Before using a Sandostatin ampoule, check the liquid for particles or a change in
colour. If you notice anything unusual, do not use the ampoule.
Once an ampoule is opened, use it immediately and throw out any liquid that remains.
The ampoule does not contain any preservative.
Give the injections between meals or at bedtime. Avoid having meals around the time
of the injections.
This will help to reduce the chance of stomach upset.
To help prevent irritation or pain at the injection site:
Choose a new site for each injection. The upper arms, thighs and abdomen are good
areas for injection.
Make sure the ampoule is at room temperature before you use it. If it has been in
the fridge, take it out half an hour before using it. You can warm it up in your hand
but don't try to heat it.
If you notice pain, stinging, tingling, burning, redness or swelling at the injection
site after the injection, gently rub the site for a few seconds.
These side effects rarely last more than 15 minutes after an injection.
If you forget to use it
Inject the dose as soon as you remember, and then go back to using it as you would
It won't do any harm if you miss a dose but some of your symptoms may come back temporarily
until you get back on schedule.
Do not use a double dose to make up for the one that you missed.
This may increase the chance of you getting an unwanted side effect.
If you have trouble remembering when to use your medicine, ask your pharmacist for
If you use too much (Overdose)
Immediately telephone your doctor or Poisons Information Centre (telephone 13 11 26),
or go to Accident and Emergency at your nearest hospital if you think that an overdose
has happened. Do this even if there are no signs of discomfort or poisoning.
Some of the symptoms of an overdose may include hot flushes, fatigue, depression (sad
mood), anxiety, lack of concentration and needing to pass water more frequently than
No life-threatening reactions have been reported after an overdose of this medicine.
While you are using Sandostatin
Things you must do
Keep all of your doctor's appointments so that your progress can be checked.
If you must use this medicine for a long time, your doctor may want to check your
blood sugar, gallbladder, thyroid and liver function from time to time to prevent
unwanted side effects from happening.
If your doctor recommends it, make sure you use a method of contraception to prevent
pregnancy during your treatment. Tell your doctor if you become pregnant while you
are receiving this medicine.
If you are about to be started on any new medicine, remind your doctor and pharmacist
that you are using Sandostatin.
Tell any other doctor, dentist or pharmacist who treats you that you are using Sandostatin.
Things you must not do
Do not give this medicine to anyone else, even if their symptoms seem to be the same
Do not use it to treat any other complaints unless your doctor tells you to.
Things to be careful of
Be careful driving, operating machinery or doing jobs that require you to be alert
until you know how Sandostatin affects you.
This medicine may cause dizziness, lightheadedness or weakness in some people. If
you have any of these symptoms, do not drive or do anything else that could be dangerous.
Tell your doctor or pharmacist as soon as possible if you do not feel well while you
are using Sandostatin.
All medicines can cause side effects. Sometimes they are serious, but most of the
time they are not. You may need medical treatment if you get some of the side effects.
Do not be alarmed by this list of possible side effects. You may not experience any
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor immediately or go to Accident and Emergency at your nearest hospital
if you notice:
signs of allergy such as rash, itching or hives on the skin; swelling of the face,
lips, tongue or other parts of the body; shortness of breath, wheezing or troubled
severe pain, tenderness or swelling in the stomach or abdomen, which may be accompanied
by fever, nausea and vomiting, yellowing of the skin and eyes, loss of appetite, generally
feeling unwell, itching, light coloured urine (symptoms of a possible problem with
your liver, pancreas or gall bladder)
symptoms of low blood glucose (hypoglycaemia), including sweating, trembling, dizziness,
weakness, hunger, palpitations (feeling of fast or irregular heartbeat) and fatigue
symptoms of high blood glucose (hyperglycaemia), including lethargy or tiredness,
headache, thirst, passing large amounts of urine, and blurred vision
unusually slow or fast heartbeat
increased bleeding or bruising (could be low level of platelets in blood).
Tell your doctor if you notice any of the following side effects and they worry you:
pain, irritation, redness, rash or swelling at the injection site
loss of appetite
indigestion, nausea or vomiting
feeling of bloating or wind
constipation, diarrhoea or other change in bowel motions
dizziness or light headedness
swelling of hands or feet due to excess fluid
tiredness or weakness
flushing of the skin
temporary hair loss
changes in the rhythm of your heartbeat
shortness of breath
symptoms of changes in the activity of the thyroid gland (hyper or hypothyroidism)
including changes in heart rate, appetites or weight, tiredness, feeling cold or sweating
too much, anxiety or swelling at the front of the neck.
Tell your doctor if you notice anything else that is making you feel unwell.
Other side effects not listed above may happen in some people.
After using Sandostatin
Keep the ampoules in the original container until it is time to use them.
You can store the ampoules for up to 2 weeks at room temperature.
If you are storing the ampoules for longer than 2 weeks, keep them in the refrigerator.
Do not freeze them.
Do not store Sandostatin or any other medicine in the bathroom or near a sink.
Do not leave them in the car or on window sills.
Keep the medicine where children cannot reach it.
If any ampoules have been left out of the fridge for longer than 2 weeks, do not use
If your doctor tells you to stop using this medicine or you find that the expiry date
has passed or the ampoules have been left out of the fridge for too long, ask your
pharmacist what to do with any medicine you have left over.
What it looks like
Sandostatin comes in 1mL glass ampoules containing a clear, colourless liquid; boxes
Sandostatin ampoules contain 0.05 mg, 0.1 mg or 0.5 mg of the active ingredient, octreotide
(as octreotide acetate). They also contain:
water for injections
Sandostatin is supplied in Australia by:
NOVARTIS Pharmaceuticals Australia Pty Limited
ABN 18 004 244 160
54 Waterloo Road
North Ryde NSW 2113
® = Registered Trademark
This leaflet was prepared in
Australian Registration Number.
Sandostatin 0.05 mg ampoule
AUST R 42192
Sandostatin 0.1 mg ampoule
AUST R 42193
Sandostatin 0.5 mg ampoule
AUST R 42191
For internal use only
(sas220118c.doc) based on PI (sas220118i.doc)